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Maintenance of androgen deprivation therapy or testosterone supplementation in the management of castration-resistant prostate cancer: that is the question
PurposeWhether or not androgen receptor (AR) axis could still be targetable in castration resistant prostate cancer (CRPC) patients with disease...
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5% Dextrose in Ringer’s Lactate versus 5% Dextrose Normal Saline as Maintenance Intravenous Fluid Therapy in Children — A Randomised Controlled Trial
ObjectivesTo estimate the difference in serum chloride levels between children receiving 5% Dextrose in Ringer’s Lactate (RLD5) vs. 5% Dextrose...
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Antiplatelet Therapy in End-stage Renal Disease Patients on Maintenance Dialysis: a State-of-the-art Review
Patients with end-stage renal disease (ESRD) on maintenance dialysis have an increased risk of ischaemic events, such as recurrent myocardial...
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The Landscape of Currently Enrolling Maintenance Trials in Multiple Myeloma
Maintenance therapies in multiple myeloma improve survival after induction treatment. This study characterizes the strategies for maintenance therapy...
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Praktische Gesichtspunkte der Asthmatherapie mit Fixkombination und „single inhaler maintenance and reliever therapy“ (SMART) bei Kindern und Jugendlichen
The potential benefits and also possible problems of a fixed combination consisting of inhaled corticosteroids (ICS) plus a long-acting beta agonist...
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The Effect of 6 Months of Methadone Maintenance Therapy on Serum Levels of Cortisol, TSH, T4, and PTH Hormones
This study aimed to investigate the effect of 6 months of methadone maintenance therapy on serum levels of cortisol, PTH, TSH, and T4 hormones. This...
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Real-World Outcomes Following First-Line Treatment in Patients with Advanced Ovarian Cancer with Multiple Risk Factors for Disease Progression who Received Maintenance Therapy or Active Surveillance
IntroductionWe evaluated real-world outcomes in patients with advanced ovarian cancer (AOC) based on their cumulative risk profile and maintenance...
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Exploratory biomarker analysis in the phase III L-MOCA study of olaparib maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer
BackgroundThe prospective phase III multi-centre L-MOCA trial (NCT03534453) has demonstrated the encouraging efficacy and manageable safety profile...
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Niraparib: A Review in First-Line Maintenance Therapy in Advanced Ovarian Cancer
Niraparib (Zejula™) is a PARP inhibitor which is approved for maintenance therapy in adults with advanced ovarian cancer in complete or partial...
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Avelumab as First-Line Maintenance Treatment in Locally Advanced or Metastatic Urothelial Carcinoma
This work provides a summary of guideline recommendations and an expert position on the use of maintenance avelumab therapy based on a review of...
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Intravenous maintenance fluid therapy practice in the pediatric acute and critical care settings: a European and Middle Eastern survey
The ideal fluid for intravenous maintenance fluid therapy (IV-MFT) in acutely and critically ill children is controversial, and evidence-based...
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ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children— a systematic review and meta-analysis
PurposeIntravenous maintenance fluid therapy (IV-MFT) prescribing in acute and critically ill children is very variable among pediatric health care...
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Investigating the rationale for COPD maintenance therapy prescription across Europe, findings from a multi-country study
This study aims to understand healthcare professionals’ thoughts and motivations about optimal management and treatment of patients with chronic...
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Efficacy of chidamide maintenance therapy versus autologous stem cell transplantation versus observation as a post-remission choice in the survival of adult patients with peripheral T-cell lymphoma: Post hoc analysis of a prospective, multicenter, phase 2 study in China
In this prospective, multicenter, Phase 2 clinical trial (NCT02987244), patients with peripheral T-cell lymphomas (PTCLs) who had responded to...
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Visual outcome of aquaporin-4 antibody-positive optic neuritis with maintenance therapy
PurposeTo assess the effect of maintenance therapy on visual outcomes in preventing recurrences one year after first onset in patients with...
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ENTPD1/CD39 as a predictive marker of treatment response to gemogenovatucel-T as maintenance therapy in newly diagnosed ovarian cancer
BackgroundBroadened use of predictive molecular and phenotypic profiling amongst oncologists has facilitated optimal integration of targeted- and...
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First Maintenance Therapy for Chronic Obstructive Pulmonary Disease: Retrospective Analyses of US and UK Healthcare Databases
IntroductionInhaled corticosteroids (ICS) are often prescribed inappropriately alongside long-acting bronchodilators for chronic obstructive...
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Cost-Effectiveness of Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma in the United States
IntroductionThe JAVELIN Bladder 100 trial showed that maintenance avelumab therapy after chemotherapy improved the survival of patients with advanced...
