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Noncoding RNAs in Cardiac Hypertrophy
Cardiac hypertrophy is classified as pathological and physiological hypertrophy. Pathological hypertrophy typically precedes the onset of heart...
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Comparative Study Between Serum Level of Lysophosphatidic Acid and CA-125 in Epithelial Ovarian Cancer
BackgroundThe aim of this study is to assess the diagnostic value of lysophosphatidic acid (LPA) in epithelial ovarian cancer (EOC) patients in...
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Serum metabolic profiling identified a distinct metabolic signature in patients with idiopathic pulmonary fibrosis – a potential biomarker role for LysoPC
BackgroundIdiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology. Patients present loss of lung function, dyspnea and dry...
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Mesenchymal stem cells in multiple myeloma: a therapeutical tool or target?
Multiple myeloma (MM) is a malignant plasma cell (PC) disorder, characterized by a complex interactive network of tumour cells and the bone marrow...
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Metastasis suppressors: functional pathways
Metastasis is a complex process and a major contributor of death in cancer patients. Metastasis suppressor genes are identified by their ability to...
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Oncogenic Epstein–Barr virus recruits Nm23-H1 to regulate chromatin modifiers
In cancer progression, metastasis is a major cause of poor survival of patients and can be targeted for therapeutic interventions. The first...
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Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets
Purpose of ReviewThe pathogenesis of systemic sclerosis depends on a complex interplay between autoimmunity, vasculopathy, and fibrosis. Reversible...
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Daily Intake of High-Fat Diet with Lysophosphatidic Acid-Rich Soybean Phospholipids Augments Colon Tumorigenesis in Kyoto Apc Delta Rats
BackgroundOral administration of lysophosphatidic acid (LPA) was shown to attenuate gastric ulceration in rats and mice but aggravate intestinal...
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MicroRNA-184 is a downstream effector of albuminuria driving renal fibrosis in rats with diabetic nephropathy
Aims/hypothesisRenal fibrosis is a common complication of diabetic nephropathy and is a major cause of end-stage renal disease. Despite the suggested...
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Comprendre le poumon agressé. Actes du séminaire de recherche translationnelle de la Société de Réanimation de Langue Française (6 décembre 2016)
The 2016 translational research meeting of the French Intensive Care Society was focused on lung defense and repair. The lung represents a crucial...
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LPA signaling is required for dopaminergic neuron development and is reduced through low expression of the LPA1 receptor in a 6-OHDA lesion model of Parkinson’s disease
Lysophosphatidic acid (LPA) is a bioactive phospholipid that activates at least five known G-protein-coupled receptors (GPCRs): LPA 1 –LPA 5 . The...
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Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer
Over the past decade the importance of lipids for cancer cell metabolism and cancer-related processes such as proliferation, metastasis and...
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Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where To Now?
Idiopathic pulmonary fibrosis (IPF) is an aging-associated, recalcitrant lung disease with historically limited therapeutic options. The recent...
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Cutaneous Manifestations of Scleroderma and Scleroderma-Like Disorders: a Comprehensive Review
Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three different subsets: localized scleroderma, limited cutaneous...
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LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage
Genetic, environmental and neurodevelopmental factors are thought to underlie the onset of neuropsychiatric disorders such as schizophrenia. How...
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Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation—Novel Paradigm and Therapeutic Potential
There are limitations in the current classification of danger-associated molecular patterns (DAMP) receptors. To overcome these limitations, we...