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Showing 41-60 of 130 results
  1. Noncoding RNAs in Cardiac Hypertrophy

    Cardiac hypertrophy is classified as pathological and physiological hypertrophy. Pathological hypertrophy typically precedes the onset of heart...

    Yongqin Li, Yajun Liang, ... Yihua Bei in Journal of Cardiovascular Translational Research
    Article 31 August 2018
  2. Comparative Study Between Serum Level of Lysophosphatidic Acid and CA-125 in Epithelial Ovarian Cancer

    Background

    The aim of this study is to assess the diagnostic value of lysophosphatidic acid (LPA) in epithelial ovarian cancer (EOC) patients in...

    Helmy A. Rady, Mohammed Mohammed Othman, ... Shimaa Abdelghany Elghrabawy in Indian Journal of Gynecologic Oncology
    Article 02 July 2018
  3. Serum metabolic profiling identified a distinct metabolic signature in patients with idiopathic pulmonary fibrosis – a potential biomarker role for LysoPC

    Background

    Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology. Patients present loss of lung function, dyspnea and dry...

    Barbara Rindlisbacher, Cornelia Schmid, ... Manuela Funke-Chambour in Respiratory Research
    Article Open access 10 January 2018
  4. Mesenchymal stem cells in multiple myeloma: a therapeutical tool or target?

    Multiple myeloma (MM) is a malignant plasma cell (PC) disorder, characterized by a complex interactive network of tumour cells and the bone marrow...

    Song Xu, Kim De Veirman, ... Ivan Van Riet in Leukemia
    Article Open access 22 February 2018
  5. Metastasis suppressors: functional pathways

    Metastasis is a complex process and a major contributor of death in cancer patients. Metastasis suppressor genes are identified by their ability to...

    Imran Khan, Patricia S Steeg in Laboratory Investigation
    Article 02 October 2017
  6. Oncogenic Epstein–Barr virus recruits Nm23-H1 to regulate chromatin modifiers

    In cancer progression, metastasis is a major cause of poor survival of patients and can be targeted for therapeutic interventions. The first...

    Saurabh Pandey, Erle S Robertson in Laboratory Investigation
    Article 16 October 2017
  7. Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets

    Purpose of Review

    The pathogenesis of systemic sclerosis depends on a complex interplay between autoimmunity, vasculopathy, and fibrosis. Reversible...

    Cristiano Sacchetti, Nunzio Bottini in Current Rheumatology Reports
    Article 10 April 2017
  8. Daily Intake of High-Fat Diet with Lysophosphatidic Acid-Rich Soybean Phospholipids Augments Colon Tumorigenesis in Kyoto Apc Delta Rats

    Background

    Oral administration of lysophosphatidic acid (LPA) was shown to attenuate gastric ulceration in rats and mice but aggravate intestinal...

    Toshihiko Tsutsumi, Manami Inoue, ... Akira Tokumura in Digestive Diseases and Sciences
    Article 03 January 2017
  9. Abstracts

    Article 01 March 2019
  10. MicroRNA-184 is a downstream effector of albuminuria driving renal fibrosis in rats with diabetic nephropathy

    Aims/hypothesis

    Renal fibrosis is a common complication of diabetic nephropathy and is a major cause of end-stage renal disease. Despite the suggested...

    Cristina Zanchi, Daniela Macconi, ... Carlamaria Zoja in Diabetologia
    Article Open access 31 March 2017
  11. Comprendre le poumon agressé. Actes du séminaire de recherche translationnelle de la Société de Réanimation de Langue Française (6 décembre 2016)

    The 2016 translational research meeting of the French Intensive Care Society was focused on lung defense and repair. The lung represents a crucial...

    A. Guillon, S. Gibot, ... F. Pène in Médecine Intensive Réanimation
    Article 22 April 2017
  12. LPA signaling is required for dopaminergic neuron development and is reduced through low expression of the LPA1 receptor in a 6-OHDA lesion model of Parkinson’s disease

    Lysophosphatidic acid (LPA) is a bioactive phospholipid that activates at least five known G-protein-coupled receptors (GPCRs): LPA 1 –LPA 5 . The...

    **ao-yun Yang, Ethan Y. Zhao, ... Yuchuan Ding in Neurological Sciences
    Article 14 July 2015
  13. Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer

    Over the past decade the importance of lipids for cancer cell metabolism and cancer-related processes such as proliferation, metastasis and...

    M T M van Jaarsveld, J M Houthuijzen, E E Voest in Oncogene
    Article 07 December 2015
  14. Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where To Now?

    Idiopathic pulmonary fibrosis (IPF) is an aging-associated, recalcitrant lung disease with historically limited therapeutic options. The recent...

    Sunad Rangarajan, Morgan L. Locy, ... Victor J. Thannickal in Drugs
    Article 04 January 2016
  15. Cutaneous Manifestations of Scleroderma and Scleroderma-Like Disorders: a Comprehensive Review

    Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three different subsets: localized scleroderma, limited cutaneous...

    Caterina Ferreli, Giulia Gasparini, ... Laura Atzori in Clinical Reviews in Allergy & Immunology
    Article 16 July 2017
  16. LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage

    Genetic, environmental and neurodevelopmental factors are thought to underlie the onset of neuropsychiatric disorders such as schizophrenia. How...

    H Mirendil, E A Thomas, ... J Chun in Translational Psychiatry
    Article Open access 07 April 2015
  17. Abstracts

    Article 01 March 2018
  18. Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation—Novel Paradigm and Therapeutic Potential

    There are limitations in the current classification of danger-associated molecular patterns (DAMP) receptors. To overcome these limitations, we...

    **n Wang, Ya-Feng Li, ... **ao-Feng Yang in Journal of Cardiovascular Translational Research
    Article 26 May 2016
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