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Radiomics predictive modeling from dual-time-point FDG PET Ki parametric maps: application to chemotherapy response in lymphoma
BackgroundTo investigate the use of dynamic radiomics features derived from dual-time-point (DTP-feature) [ 18 F]FDG PET metabolic uptake rate K i ...
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In vitro kinetic release study of ketoprofen enantiomers from alginate metal complexes
BackgroundTo explore the release behavior of ketoprofen enantiomers from alginate-metal-complexes. Five mathematical models of drug release kinetics...
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Kinetic metrics of 18F-FDG in normal human organs identified by systematic dynamic total-body positron emission tomography
PurposeTo investigate the kinetic metrics of 2-[ 18 F]-fluoro-2-deoxy- d -glucose ( 18 F-FDG) in normal organs by using dynamic total-body (TB) positron...
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Assessing the impact of different penalty factors of the Bayesian reconstruction algorithm Q.Clear on in vivo low count kinetic analysis of [11C]PHNO brain PET-MR studies
IntroductionQ.Clear is a Bayesian penalised likelihood (BPL) reconstruction algorithm available on General Electric (GE) Positron Emission Tomography...
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Imaging glymphatic response to glioblastoma
BackgroundThe glymphatic system actively exchanges cerebrospinal fluid (CSF) and interstitial fluid (ISF) to eliminate toxic interstitial waste...
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Accurate image derived input function in [18F]SynVesT-1 mouse studies using isoflurane and ketamine/xylazine anesthesia
BackgroundKinetic modeling in positron emission tomography (PET) requires measurement of the tracer plasma activity in the absence of a suitable...
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Not deep enough: Modeling the effect of shallow placement of the DaVinci ** “bariatric” long trocar on the muscular abdominal wall
IntroductionThe DaVinci ** Robotic Surgical System (**) long cannula (Intuitive Surgical Company, Sunnyvale, CA) provides five additional centimeters...
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Glioblastoma PET/MRI: kinetic investigation of [18F]rhPSMA-7.3, [18F]FET and [18F]fluciclovine in an orthotopic mouse model of cancer
PurposeGlioblastoma multiforme (GBM) is the most common glioma and standard therapies can only slightly prolong the survival. Neo-vascularization is...
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Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling
Background and ObjectiveThe use of bedaquiline as a treatment option for drug-resistant tuberculosis meningitis (TBM) is of interest to address the...
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Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants
BackgroundMeropenem is a broad-spectrum carbapenem antibiotic approved by the US Food and Drug Administration for use in pediatric patients,...
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Effects of real-time feedback during decline walking on kinematic and kinetic gait parameters in a healthy population: study protocol for a randomized trial — up and down
BackgroundThe control of the dynamic functional leg alignment (dFLA) and biomechanical load are important joint-related aspects regarding the...
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Framing protocol optimization in oncological Patlak parametric imaging with uKinetics
PurposeTotal-body PET imaging with ultra-high sensitivity makes high-temporal-resolution framing protocols possible for the first time, which allows...
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Ultra-low-activity total-body dynamic PET imaging allows equal performance to full-activity PET imaging for investigating kinetic metrics of 18F-FDG in healthy volunteers
PurposeTo investigate the feasibility of ultra-low-activity total-body positron emission tomography (PET) dynamic imaging for quantifying kinetic...
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Mathematical Modeling and Simulations for Develo** Nanoparticle-Based Cancer Drug Delivery Systems: A Review
Purpose of ReviewNanoparticles are crucial for develo** patient-/target-specific drug delivery systems. In recent days, mathematical modeling and...
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Leveraging Computational Modeling to Understand Infectious Diseases
Purpose of ReviewComputational and mathematical modeling have become a critical part of understanding in-host infectious disease dynamics and...
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Modeling of postprandial glycemic response by consecutive reaction kinetics model for precise glycemic control
ObjectiveThe dynamics of postprandial glycemic response are crucial for human health, while there is currently a lack of efficient models that can...
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Step by Step Guide to Understanding the Kinetic Chain Concept in the Overhead Athlete
Purpose of ReviewThe purpose of this review will be to provide both a historical and recent review of the role of the kinetic chain for the overhead...
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An update on the use of image-derived input functions for human PET studies: new hopes or old illusions?
BackgroundThe need for arterial blood data in quantitative PET research limits the wider usability of this imaging method in clinical research...
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Predicting [177Lu]Lu-HA-DOTATATE kidney and tumor accumulation based on [68Ga]Ga-HA-DOTATATE diagnostic imaging using semi-physiological population pharmacokinetic modeling
BackgroundPrediction of [ 177 Lu]Lu-HA-DOTATATE kidney and tumor uptake based on diagnostic [ 68 Ga]Ga-HA-DOTATATE imaging would be a crucial step for...
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Assessing dynamic metabolic heterogeneity in prostate cancer patients via total-body [68Ga]Ga-PSMA-11 PET/CT imaging: quantitative analysis of [68Ga]Ga-PSMA-11 uptake in pathological lesions and normal organs
PurposeThis study aimed to quantitatively assess [ 68 Ga]Ga-PSMA-11 uptake in pathological lesions and normal organs in prostate cancer using the...
