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Considering the Oral Bioavailability of Protein Kinase Inhibitors: Essential in Assessing the Extent of Drug–Drug Interaction and Improving Clinical Practice
Protein kinase inhibitors share pharmacokinetic (PK) pathways among themselves. They are all metabolized by several cytochromes P450 (CYP). For most...
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Barriers and facilitators to exercise among adult cancer survivors in Singapore
PurposeExercise can help cancer survivors manage sequela, treatment side effects, improve overall quality of life, and is recommended for most. The...
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Acetabular roof lesions in children: a descriptive study and literature review
BackgroundAcetabular roof lesions (ARLs) in children are uncommon and may involve a variety of diseases. The acetabular roof is the main...
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P63-negative pulmonary NUT carcinoma arising in the elderly: a case report
BackgroundPulmonary NUT carcinoma is rare, but lethal, thus, must not be overlooked. The definitive diagnosis is made by a NUT monoclonal antibody or...
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Chidamide, Decitabine, Cytarabine, Aclarubicin, and Granulocyte Colony-stimulating Factor Therapy for Patients with Relapsed/Refractory Acute Myeloid Leukemia: A Retrospective Study from a Single-Center
ObjectivePreclinical evidence and clinical trials have suggested synergistic effects of epigenetic modifiers in combination with cytotoxic agents for...
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MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves Imatinib Resistance by Targeting KDM4D Expression
ObjectiveGastrointestinal stromal tumors (GISTs) can rapidly proliferate through angiogenesis. Previous studies indicated the potential influence of...
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Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy
Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in human health. An altered microbiome can be...
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New clinical trial design in precision medicine: discovery, development and direction
In the era of precision medicine, it has been increasingly recognized that individuals with a certain disease are complex and different from each...
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Clinical Analysis of Primary Tracheobronchial Tumors in Children and Evaluation of the Predicting Models for Mucoepidermoid Carcinoma
ObjectiveTo determine the clinical characteristics and prognosis of primary tracheobronchial tumors (PTTs) in children, and to explore the most...
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The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms
We herein present an overview of the upcoming 5 th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on...
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Early Radiation-induced Leiomyosarcoma after Right Mastectomy in an 83-year old Woman
Radiation-induced sarcomas (RIS) are rare aggressive entities which usually occur many years after radiotherapy. We present a case of an aggressive...
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Tumor microenvironment and immunotherapy of oral cancer
Oral cancer is one of the most common malignant tumors of the head and neck, not only affects the appearance, but also affects eating and even...
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Intraperitoneal extraosseous osteosarcoma: a case report and literatures review
BackgroundTo investigate the clinical imaging manifestations, diagnosis and treatment of intraperitoneal extraosseous osteosarcoma.
Case presentation ...
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Acute infectious osteomyelitis in children: new treatment strategies for an old enemy
BackgroundAcute osteomyelitis still represents a significant clinical challenge, with an increasing incidence in paediatric population. A careful...