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Experimental parameters and infarct size in closed chest pig LAD ischemia reperfusion models; lessons learned
BackgroundPreclinical models that resemble the clinical setting as closely as possible are essential in translating promising therapies for the...
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Exercise Training: The Holistic Approach in Cardiovascular Prevention
Nowadays, there are robust clinical and pathophysiological evidence supporting the beneficial effects of physical activity on cardiovascular (CV)...
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Echocardiographic tissue imaging evaluation of myocardial characteristics and function in cardiomyopathies
Current echocardiography techniques have allowed more precise assessment of cardiac structure and function of the several types of cardiomyopathies....
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A new scheme of global feature management improved the performance and stability of radiomics model: a study based on CT images of acute brainstem infarction
ObjectiveThe performance and stability of radiomics model caused by dimension reduction remain being confronted with major challenges. In this study,...
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Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair
Exosome therapy holds great promise as a novel approach to improve acute skin wound healing. This review provides a comprehensive overview of the...
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Topical application of adipose tissue-derived mesenchymal stem cells (ADMSCs) reduced cerebral edema in experimental traumatic brain injury (TBI)—a preliminary study
BackgroundOur previous studies showed that topical application of mesenchymal stem cells (MSCs) improved functional recovery in rat traumatic brain...
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Germany’s journey toward 14 Tesla human magnetic resonance
Multiple sites within Germany operate human MRI systems with magnetic fields either at 7 Tesla or 9.4 Tesla. In 2013, these sites formed a network to...
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Factors Associated with Reinitiation of Statin Treatment in Older Patients with Peripheral Arterial Disease
BackgroundLong-term persistence represents a basic precondition of successful statin treatment in patients with peripheral arterial disease (PAD).
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Continuous wound infusion with ropivacaine alone provides adequate analgesia following laparotomy
BackgroundAlthough continuous wound infusion (CWI) with local anaesthetic has been used as an adjunct for pain relief following laparotomy, its use...
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Expanding controlled donation after the circulatory determination of death: statement from an international collaborative
A decision to withdraw life-sustaining treatment (WLST) is derived by a conclusion that further treatment will not enable a patient to survive or...
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Introduction of CTA-index as Simplified Measuring Method for Thrombus Perviousness
PurposeThrombus features on admission CT are useful imaging markers for clot characterization, stroke pathogenesis and outcome prediction. In this...
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Intercellular mitochondrial transfer as a means of tissue revitalization
As the crucial powerhouse for cell metabolism and tissue survival, the mitochondrion frequently undergoes morphological or positional changes when...
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Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier
Exosomes are membranous vesicles with a 30 to 150 nm diameter secreted by mesenchymal stem/stromal cells (MSCs) and other cells, such as immune cells...
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Austrian recommendations for the management of essential thrombocythemia
According to the World Health Organization (WHO) classification, essential (primary) thrombocythemia (ET) is one of several Bcr-Abl negative chronic...
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Impact of the elderly donor on an abdominal organ transplantation program
BackgroundOlder donors have become widespread in recent years. Given that they have comorbidities, the treatment of theses donors is crucial. Our aim...
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Reevaluation of risk factors for time to subsequent events after first stroke occurrence using a new weighted all-cause effect measure
BackgroundRisk diseases and risk factors for stroke include atrial fibrillation, hypertension, diabetes mellitus, smoking, and elevated...
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Protein acylation: mechanisms, biological functions and therapeutic targets
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and...
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A study of optimal concentration range and time window of sevoflurane preconditioning for brain protection in MCAO rats
BackgroundSevoflurane preconditioning improves brain function in MCAO rats, and there are several methods for determining appropriate concentration...
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Serum potassium and heart failure: association, causation, and clinical implications
Dyskalemia (hypo- and hyperkalemia) is a common clinical encounter in patients with heart failure (HF), linked to underlying pathophysiologic...
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Evaluating agreement between bodies of evidence from randomized controlled trials and cohort studies in medical research: a meta-epidemiological study
BackgroundRandomized controlled trials (RCTs) and cohort studies are the most common study design types used to assess the treatment effects of...
