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Fréquence et facteurs de risque des Smur de seconde intention dans les intoxications médicamenteuses volontaires
AimAcute drug self-poisoning (DSP) is frequently encountered in emergency medical services. Previous studies seem to show that poisoning dispatch is...
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Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, im**es on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy
IntroductionSpleen tyrosine kinase (SYK) is a key integrator of intracellular signals triggered by activated immunoreceptors, including Bcell...
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Admission insulin resistance index in nondiabetic patients with acute coronary syndrome: clinical and angiographic features
BackgroundThe clinical implication of insulin resistance has extended beyond diabetes mellitus to include ischemic heart disease, dyslipidemia,...
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Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population
The insulin receptor substrate-1 ( IRS1 ) plays an important role in insulin signaling. A recent genome-wide association study identified rs2943641C>T...
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Zinc homeostasis in the metabolic syndrome and diabetes
Zinc (Zn) is an essential mineral that is required for various cellular functions. Zn dyshomeostasis always is related to certain disorders such as...
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Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases
Somatic missense mutations in PIK3CA , which encodes the p110α catalytic subunit of phosphoinositide 3-kinases, occur frequently in human cancers....
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Psychopharmaka und Diabetes
Psychotropic drugs, such as antipsychotics and antidepressants, are widely used substances which can display marked metabolic side effects....
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Analysis of phosphatidylinositol 3-kinase activation in the adipose tissue of gestational diabetes mellitus patients and insulin resistance
The P85 regulatory subunit protein and gene expression and P110 catalylic subunit activity of phosphatidylinositol 3-kinase (PI-3K) were investigated...