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Machine learning-based protein signatures for differentiating hypertensive disorders of pregnancy
Hypertensive disorders of pregnancy (HDP) result in major maternal and fetal complications. Our study aimed to find a panel of protein markers to...
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Synergistic upregulation of ADAMTS4 (aggrecanase-1) by cytokines and its suppression in knee osteoarthritic synovial fibroblasts
The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family includes nine members with aggrecan-degrading activity, i.e.,...
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Time course of serum cytokine level changes within 72 h after onset in children with acute encephalopathy and febrile seizures
BackgroundCytokine levels have been measured in acute encephalopathy (AE) to determine its pathology or as a diagnostic biomarker to distinguish it...
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Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia
BackgroundNeutrophils play a crucial role in inflammation and in the increased thrombotic risk in myeloproliferative neoplasms (MPNs). We have...
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Anti-tumor effects of tirbanibulin in squamous cell carcinoma cells are mediated via disruption of tubulin-polymerization
Topical tirbanibulin is a highly effective and well tolerated novel treatment option for actinic keratoses (AKs). This study aimed to characterize...
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The protective role of chicken cathelicidin-1 against Streptococcus suis serotype 2 in vitro and in vivo
Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen with the characteristics of high mortality and morbidity, which brings great...
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Effects of antioxidant vitamins (A, D, E) and trace elements (Cu, Mn, Se, Zn) administration on gene expression, metabolic, antioxidants and immunological profiles during transition period in dromedary camels
BackgroundNutrition has a primary role for optimum expression of genetic potential, and most of the farmers have limited resources of green fodder....
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Gastric cancer mesenchymal stem cells via the CXCR2/HK2/PD-L1 pathway mediate immunosuppression
BackgroundAnti-PD-1 immunotherapy has emerged as an important therapeutic modality in advanced gastric cancer (GC). However, drug resistance...
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The effect of azithromycin on sputum inflammatory markers in bronchiectasis
BackgroundLong term macrolide treatment has been found beneficial in bronchiectasis (BE) -pathogical bronchial dilatation- possibly due to a combined...
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Tocotrienol-rich fraction reduces retinal inflammation and angiogenesis in rats with streptozotocin-induced diabetes
BackgroundDiabetic retinopathy (DR) is the second commonest microvascular complication of diabetes mellitus. It is characterized by chronic...
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Systemic immune markers and infection risk in preterm infants fed human milk fortified with bovine colostrum or conventional fortifier, a secondary analysis of the FortiColos trial
BackgroundFor very preterm infants, human milk is often fortified with formula products based on processed bovine milk. Intact bovine colostrum (BC),...
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Adult zebrafish infected by clinically isolated Klebsiella pneumoniae with different virulence showed increased intestinal inflammation and disturbed intestinal microbial biodiversity
BackgroundKlebsiella pneumoniae is a pathogen that often infects patients in clinical practice. Due to its high virulent and drug resistance,...
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miR-181c, a potential mediator for acute kidney injury in a burn rat model with following sepsis
BackgroundThe miRNA profile is changed after burn or sepsis and is involved in regulating inflammatory reactions. However, the function and molecular...
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IL-10 producing regulatory B cells are decreased in blood from smokers and COPD patients
BackgroundTwo opposing B cell subsets have been defined based on their cytokine profile: IL-6 producing effector B cells (B-effs) versus IL-10...
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Integrated network pharmacology and experimental validation to explore the potential pharmacological mechanism of Qihuang Granule and its main ingredients in regulating ferroptosis in AMD
BackgroundQihuang Granule (QHG) is a traditional prescription that has exhibited potential in safeguarding against age-related maculopathy (AMD)....
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A Cellular Senescence-Related Signature Predicts Cervical Cancer Patient Outcome and Immunotherapy Sensitivity
Cervical cancer (CC) is one of the most prevalent gynecological malignancies. The rate of mortality and morbidity among patients with CC is high....
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Liushen Capsules, a promising clinical candidate for COVID-19, alleviates SARS-CoV-2-induced pulmonary in vivo and inhibits the proliferation of the variant virus strains in vitro
BackgroundCoronavirus disease 2019 (COVID-19) causes a global pandemic and has devastating effects around the world, however, there are no specific...
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Overcoming cancer-associated fibroblast-induced immunosuppression by anti-interleukin-6 receptor antibody
Cancer-associated fibroblasts (CAFs) are a critical component of the tumor microenvironment and play a central role in tumor progression. Previously,...
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**-Gui-Shen-Qi Wan ameliorates diabetic retinopathy by inhibiting apoptosis of retinal ganglion cells through the Akt/HIF-1α pathway
Background**-Gui-Shen-Qi Wan (JGSQ) has been used in China for thousands of years to treat various ailments, including frequent urination, blurred...
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Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data
BackgroundHormonal changes during the menstrual cycle play a key role in sha** immunity in the cervicovaginal tract. Cervicovaginal fluid contains...
