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Quality control methods in musculoskeletal tissue engineering: from imaging to biosensors
Tissue engineering is rapidly progressing toward clinical application. In the musculoskeletal field, there has been an increasing necessity for bone...
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Biomaterials science and surface engineering strategies for dental peri-implantitis management
Peri-implantitis is a bacterial infection that causes soft tissue inflammatory lesions and alveolar bone resorption, ultimately resulting in implant...
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Adeno-associated virus as a delivery vector for gene therapy of human diseases
Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to...
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Hydrogel based tissue engineering and its future applications in personalized disease modeling and regenerative therapy
BackgroundEvolution in the in vitro cell culture from conventional 2D to 3D technique has been a significant accomplishment. The 3D culture models...
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Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs
Several in vitro models have been developed to mimic chronic lymphocytic leukemia (CLL) proliferation in immune niches; however, they typically do...
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Asking the Right Questions—Human Factors Considerations for Telemedicine Design
Purpose of ReviewThe goal of this paper was to provide a narrative review of human factors considerations for telemedicine. It also sought to provide...
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Mini review: human clinical studies of stem cell therapy in keratoconus
Treatment of keratoconus is one of the most interesting research fields for researchers in the world. Regenerative medicine based on human stem cells...
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T. gondii excretory proteins promote the osteogenic differentiation of human bone mesenchymal stem cells via the BMP/Smad signaling pathway
BackgroundBone defects, resulting from substantial bone loss that exceeds the natural self-healing capacity, pose significant challenges to current...
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Tissue Engineering Strategies for Improving Beta Cell Transplantation Outcome
Purpose of ReviewBeta cell replacement therapy as a form of islet transplantation is a promising alternative therapy with the possibility to make...
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Nurses’ preferences for interventions to improve infection prevention and control behaviors based on systems engineering initiative to patient safety model: a discrete choice experiment
BackgroundThe evidence of preferences for infection prevention and control (IPC) intervention from system perspective was lacked. This study aimed to...
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Investigation of the optimal light parameters for photobiomodulation to induce osteogenic differentiation of the human bone marrow stem cell and human umbilical vein endothelial cell co-culture
Bones have an important role in the human body with their complex nature. Mesenchymal stem cells and endothelial cells together support their unique...
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Engineering the next generation of CAR-NK immunotherapies
Over the past few years, cellular immunotherapy has emerged as a novel treatment option for certain forms of hematologic malignancies with multiple...
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Eight Strategies to Engineer Acceptance of Human Germline Modifications
Until recently, scientific consensus held firm that genetically manipulated embryos created through methods including Mitochondrial Replacement...
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Effect of improvement measures in reducing interruptions in a Japanese hospital pharmacy using a synthetic approach based on resilience engineering and systems thinking
BackgroundWorkflow interruptions in pharmacies contribute to dispensing errors, a high-priority issue in patient safety, but have rarely been studied...
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Identifying Risk Factors for Attention-Deficit/Hyperactivity Disorder (ADHD): a Public Health Concern and Opportunity
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders with significant individual and societal...
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Advancing preclinical models of psychiatric disorders with human brain organoid cultures
Psychiatric disorders are often distinguished from neurological disorders in that the former do not have characteristic lesions or findings from...
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Optimizing aseptic and serum milieu for the isolation of human whole umbilical cord tissue-derived mesenchymal stem cells
BackgroundMesenchymal stem cells (MSCs) have become an attractive tool for tissue engineering and targets in clinical transplantation due to their...
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Scaffolds: a biomaterial engineering in targeted drug delivery for osteoporosis
Osteoporosis is an increasingly common condition that causes low bone density, porous bone, and increased fracture risk. Treatments for osteoporosis...
