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GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity
Inhibitory myeloid cells and their cytokines play critical roles in limiting chimeric antigen receptor T (CART) cell therapy by contributing to the...
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B cell‐activating factors in autoimmune pulmonary alveolar proteinosis
BackgroundAutoimmune pulmonary alveolar proteinosis (APAP) results from the suppression of granulocyte-macrophage colony-stimulating factor (GM-CSF)...
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CMAHP promotes metastasis by reducing ubiquitination of Snail and inducing angiogenesis via GM-CSF overexpression in gastric cancer
Pseudogenes are generally considered “junk” DNA or “genomic fossils” generated during the evolution process that lack biological activity. However,...
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Infants with Down syndrome and congenital heart disease have altered peri-operative immune responses
BackgroundInfants with Down syndrome (DS) have an altered immune response. We aimed to characterise the inflammatory response in infants with DS and...
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IL-2/GM-CSF enhances CXCR3 expression in CAR-T cells via the PI3K/AKT and ERK1/2 pathways
ObjectiveTo investigate the effects of cytokines IL-2 and GM-CSF on CXCR3 expression and chemotaxis of CAR-T cells.
BackgroundHigh lymphocyte...
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Mesenchymal-epithelial Transition Factor Regulates Monocyte Function during Mycobacterial Infection via Indoleamine 2,3-dioxygenase
ObjectiveMycobacterium tuberculosis ( Mtb ), the causative agent of tuberculosis (TB), causes an estimated 1.6 million human deaths annually, but the...
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Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate immune system, macrophages...
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Potential involvement of IL-32 in cell-to-cell communication between macrophages and hepatoblastoma
PurposeThis study investigated the expression of interleukin 32 (IL-32) in hepatoblastoma, the most common primary pediatric liver tumor, and its...
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VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses
BackgroundVISTA is a well-known immune checkpoint in T cell biology, but its role in innate immunity is less established. Here, we investigated the...
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Functional enhancement of mesothelin-targeted TRuC-T cells by a PD1-CD28 chimeric switch receptor
T cells expressing a mesothelin (MSLN)-specific T cell receptor fusion construct (TRuC ® ), called TC-210, have demonstrated robust antitumor activity...
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A phase I/II study of LY3022855 with BRAF/MEK inhibition in patients with Melanoma
BRAF/MEK targeted therapies and immune checkpoint inhibition have dramatically improved disease control and survival of patients with advanced...
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The Role of Innate Immune Cells in Allergen Immunotherapy
Purpose of reviewAllergic diseases have become a major health challenge across the world in recent years. Allergen immunotherapy (AIT) is the only...
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Macrophages in immunoregulation and therapeutics
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host...
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Innate immune memory in inflammatory arthritis
The concept of immunological memory was demonstrated in antiquity when protection against re-exposure to pathogens was observed during the plague of...
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Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a formidable challenge due to its immunosuppressive...
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Recent Updates in the Immunopathology of Type 3 Immunity-Mediated Enthesitis
Purpose of ReviewEnthesitis is a cardinal feature of spondyloarthritis (SpA). Despite increasing available treatments, challenges remain in...
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Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion
Paradoxically, tumor development and progression can be inhibited and promoted by the immune system. After three stages of immune editing, namely,...
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Autotaxin inhibition attenuates the aortic valve calcification by suppressing inflammation-driven fibro-calcific remodeling of valvular interstitial cells
BackgroundPatients with fibro-calcific aortic valve disease (FCAVD) have lipid depositions in their aortic valve that engender a proinflammatory...
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Effect of acute inflammatory reaction induced by biopsy on tumor microenvironment
When it comes to the diagnosis of solid tumors, biopsy is always the gold standard. However, traumatic and inflammatory stimuli are so closely...
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Divergent clinical outcomes in a phase 2B trial of the TLPLDC vaccine in preventing melanoma recurrence and the impact of dendritic cell collection methodology: a randomized clinical trial
BackgroundA randomized, double-blind, placebo-controlled phase 2b trial of the tumor lysate, particle-loaded, dendritic cell (TLPLDC) vaccine was...
