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A cross-sectional study of ERG expression and the relationship with clinicopathological features of Prostate cancer in Southwestern Uganda
BackgroundProstate cancer is the leading cause of cancer-related death and the second most commonly diagnosed cancer among men in Uganda and most...
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Prognostic Impact of Different Gleason Patterns on Biopsy Within Grade Group 4 Prostate Cancer
BackgroundGrade group (GG) 4 prostate cancer (PC) is considered a single entity; however, there are questions regarding prognostic heterogeneity....
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Pre-diagnosis urine exosomal RNA (ExoDx EPI score) is associated with post-prostatectomy pathology outcome
PurposeExoDx Prostate IntelliScore (EPI) is a non-invasive urine exosome RNA-based test for risk assessment of high-grade prostate cancer. We...
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Artificial intelligence assistance significantly improves Gleason grading of prostate biopsies by pathologists
The Gleason score is the most important prognostic marker for prostate cancer patients, but it suffers from significant observer variability....
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Homologous recombination deficiency (HRD) score in aggressive prostatic adenocarcinoma with or without intraductal carcinoma of the prostate (IDC-P)
BackgroundIntraductal carcinoma of the prostate (IDC-P) is a subtype of prostate cancer featured by poor prognosis. Previous studies suggested IDC-P...
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Structured approach to resolving discordance between PI-RADS v2.1 score and targeted prostate biopsy results: an opportunity for quality improvement
BackgroundProstate multiparametric magnetic resonance imaging (mpMRI) can identify lesions within the prostate with characteristics identified in...
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Robot-assisted vs open retropubic radical prostatectomy: a propensity score-matched comparative analysis based on 15 years and 18,805 patients
PurposeTo compare oncological, functional, and surgical outcomes of a large cohort of patients who underwent open retropubic radical prostatectomy...
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Six-year outcomes of robot-assisted radical prostatectomy versus volumetric modulated arc therapy for localized prostate cancer: A propensity score-matched analysis
BackgroundAlthough robot-assisted radical prostatectomy (RARP) and intensity-modulated radiotherapy are the leading respective techniques of...
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Predicting Gleason sum upgrading from biopsy to radical prostatectomy pathology: a new nomogram and its internal validation
BackgroundTo explore the rate of Gleason sum upgrading (GSU) from biopsy to radical prostatectomy pathology and to develop a nomogram for predicting...
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A comprehensive prostate biopsy standardization system according to quantitative multiparametric MRI and PSA value: P.R.O.S.T score
BackgroundAlthough most studies believe that systematic biopsy (SB) and targeted biopsy (TB) should be performed simultaneously in patients with...
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The prognostic nomogram for PSA-incongruent low-risk prostate cancer treated by radical prostatectomy
ObjectiveTo establish a prognostic nomogram for PSA-incongruent low-risk prostate cancer (PCa) patients (Gleason score 6 and clinical stage T2a) at...
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Comparing 12-core and 20-core biopsy for prostate cancer diagnosis with transperineal MR/US fusion biopsy: assessing the effective number of systemic cores using propensity score matching
PurposeFor transperineal (TP) prostate biopsy, target biopsy for visible lesions on MRI is important, but there is no consensus of the number of...
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Artificial intelligence unravels interpretable malignancy grades of prostate cancer on histology images
Malignancy grading of prostate cancer (PCa) is fundamental for risk stratification, patient counseling, and treatment decision-making. Deep learning...
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Inter-observer variability of cribriform architecture and percent Gleason pattern 4 in prostate cancer: relation to clinical outcome
The Grade group is an important parameter for clinical decision-making in prostate cancer. Recently, percent Gleason pattern 4 and presence of...
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Evaluation of relationships between the final Gleason score, PI-RADS v2 score, ADC value, PSA level, and tumor diameter in patients that underwent radical prostatectomy due to prostate cancer
IntroductionThis study aimed to investigate the relationship between the serum PSA level, Gleason score (GS), PI-RADS v2 score, tumor ADC min value,...
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mEPE-score: a comprehensive grading system for predicting pathologic extraprostatic extension of prostate cancer at multiparametric magnetic resonance imaging
ObjectiveTo investigate the diagnostic accuracy of the PI-RADS v2.1 multiparametric magnetic resonance imaging (mpMRI) features in predicting...
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HSF1 is a novel prognostic biomarker in high-risk prostate cancer that correlates with ferroptosis
BackgroundProstate cancer (PC) is the most common cancer in older men in Europe and the United States and has the second highest death rate among...
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Development and validation of a deep learning-based microsatellite instability predictor from prostate cancer whole-slide images
Microsatellite instability-high (MSI-H) is a tumor-agnostic biomarker for immune checkpoint inhibitor therapy. However, MSI status is not routinely...
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Characterization of metabolism-associated molecular patterns in prostate cancer
BackgroundMetabolism is a hallmark of cancer and it involves in resistance to antitumor treatment. Therefore, the purposes of this study are to...
