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Association and interaction of the MC4R rs17782313 polymorphism with plasma ghrelin, GLP-1, cortisol, food intake and eating behaviors in overweight/obese Iranian adults
BackgroundRecent studies have shown that obesity is largely influenced by heredity and created by the interactions between several genes and...
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Evaluate the effects of serum urate level on bone mineral density: a genome-wide gene–environment interaction analysis in UK Biobank cohort
IntroductionSerum urate is associated with BMD and may be a protective factor. However, the exact association and mechanism are still unclear. We...
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Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus
ObjectiveGene-diet interaction plays a key role in the inter-individual differences in lipid abnormalities as a major risk factor for cardiovascular...
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Maternal depressive symptoms and children’s cognitive school readiness: the role of gene-environment interplay
Maternal depressive symptoms are a robust risk factor for poor cognitive outcomes in children, yet the role of gene-environment interplay in this...
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Fetal programming and lactation: modulating gene expression in response to undernutrition during intrauterine life
BackgroundAdverse environmental conditions during intrauterine life, known as fetal programming, significantly contribute to the development of...
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Interaction between antibiotic use and MS4A2 gene polymorphism on childhood eczema: a prospective birth cohort study
BackgroundEczema is usually the first allergic manifestation to appear in life attributed to gene–environment interactions. IL13 , IL4 , MS4A2 and ILR4A ...
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Factors associated with clonal hematopoiesis and interaction with marrow environment
Clonal hematopoiesis (CH) is an expansion of clones in individuals without any hematologic abnormalities, often carrying the driver mutations...
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Appraisal of Gene-Environment Interactions in GWAS for Evidence-Based Precision Nutrition Implementation
Purpose of ReviewThis review aims to analyse the currently reported gene-environment (G × E) interactions in genome-wide association studies (GWAS),...
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Identification of shared gene signatures in major depressive disorder and triple-negative breast cancer
BackgroundPatients with major depressive disorder (MDD) have an increased risk of breast cancer (BC), implying that these two diseases share similar...
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Association of CIITA (rs8048002) and CLEC2D (rs2114870) gene variants and type 1 diabetes mellitus
BackgroundType I diabetes mellitus (T1DM) is a significant health challenge, especially for children, owing to its chronic autoimmune nature....
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Metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL gene
BackgroundMetabolic syndrome (MetS), a cluster of metabolic and cardiovascular risk factors is influenced by environmental, lifestyle, and genetic...
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Relationship between SLC6A2 gene polymorphisms and brain volume in Han Chinese adults who lost their sole child
BackgroundNorepinephrine transporter (NET) is encoded by the SLC6A2 gene and is a potential target for studying the pathogenesis of PTSD. To the...
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LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women
ObjectivesTo assess LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass (ABM) in postmenopausal women.
Methods ...
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In search of environmental risk factors for obsessive-compulsive disorder: study protocol for the OCDTWIN project
BackgroundThe causes of obsessive-compulsive disorder (OCD) remain unknown. Gene-searching efforts are well underway, but the identification of...
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Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment
BackgroundObesity and neurodevelopmental delay are complex traits that often co-occur and differ between boys and girls. Prenatal exposures are...
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Environmental enrichment alleviates hyperalgesia by modulating central sensitization in a nitroglycerin-induced chronic migraine model of mice
BackgroundChronic migraine (CM) is a debilitating neurofunctional disorder primarily affecting females, characterized by central sensitization....
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The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals
BackgroundRecent studies have shown that dietary intakes and gene variants have a critical role in the obesity related comorbidities. This study...
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Candidate biomarkers from the integration of methylation and gene expression in discordant autistic sibling pairs
While the genetics of autism spectrum disorders (ASD) has been intensively studied, resulting in the identification of over 100 putative risk genes,...
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Association of serotonin receptor gene polymorphisms with anorexia nervosa: a systematic review and meta-analysis
PurposeSeveral studies have investigated the association between anorexia nervosa and polymorphisms of genes regulating serotonin neurotransmission,...
