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Zanubrutinib-lenalidomide-rituximab (ZR2) in unfit diffuse large B-cell lymphoma: efficient and tolerant
The objective of this study is to examine the effectiveness and safety of zanubrutinib, rituximab, and lenalidomide (ZR 2 ) in unfit patients with...
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The bleeding diathesis in patients with hereditary haemorrhagic telangiectasia is not due to impaired platelet function
BackgroundPatients with the rare disease; Hereditary haemorrhagic telangiectasia (HHT) often bleed from telangiectatic lesions in mucosal surfaces....
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Contemporary management of major haemorrhage in critical care
Haemorrhagic shock is frequent in critical care settings and responsible for a high mortality rate due to multiple organ dysfunction and...
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Advances in MicroRNA Therapy for Heart Failure: Clinical Trials, Preclinical Studies, and Controversies
Heart failure (HF) is a rapidly growing public health issue with more than 37.7 million patients worldwide and an annual healthcare cost of $108...
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Membrane procoagulation and N‑terminomics/TAILS profiling in Montreal platelet syndrome kindred with VWF p.V1316M mutation
BackgroundThe Montreal platelet syndrome kindred (MPS) with VWF p.V1316M mutation (2B-VWDMPS) is an extremely rare disorder. It has been associated...
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Role of platelets and platelet receptors in cancer metastasis
The interaction of tumor cells with platelets is a prerequisite for successful hematogenous metastatic dissemination. Upon tumor cell arrival in the...
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Interplay between inflammation and thrombosis in cardiovascular pathology
Thrombosis is the most feared complication of cardiovascular diseases and a main cause of death worldwide, making it a major health-care challenge....
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Pathogenesis of cardiovascular events in BCR-ABL1-negative myeloproliferative neoplasms
Thrombosis, both in arterial and venous territories, is the major complication of myeloproliferative neoplasms and is responsible for a high rate of...
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Rumex acetosa modulates platelet function and inhibits thrombus formation in rats
BackgroundThe Rumex acetosa has been used in medicinal treatment, food technology and phytotherapeutics in Eastern Asia and many other countries....
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Testosterone-to-estradiol ratio and platelet thromboxane release in ischemic heart disease: the EVA project
BackgroundData on the interplay between sexual hormones balance, platelet function and clinical outcomes of adults with ischemic heart disease (IHD)...
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Perioperative Platelet Transfusion: Not All Platelet Products Are Created Equal
Purpose of ReviewThis review highlights current advances in platelet components for transfusion in the perioperative setting while explaining point...
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An Updated Review on Glycoprotein IIb/IIIa Inhibitors as Antiplatelet Agents: Basic and Clinical Perspectives
The glycoprotein (GP) IIb/IIIa receptor is found integrin present in platelet aggregations. GP IIb/IIIa antagonists interfere with platelet...
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The Role of ADAM17 in Inflammation-Related Atherosclerosis
Atherosclerosis is a chronic inflammatory disease that poses a huge economic burden due to its extremely poor prognosis. Therefore, it is necessary...
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Establishment of a megakaryoblastic cell line for conventional assessment of platelet calcium signaling
Platelet function tests utilizing agonists or patient serum are generally performed to assess platelet activation ex vivo. However, inter-individual...
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Von Willebrand Factor and Platelet Aggregation: from Bench to Clinical Practice
Purpose of ReviewThis review describes von Willebrand factor (VWF)-mediated platelet function in inherited and acquired bleeding disorders, and...
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Lipoprotein(a), platelet function and cardiovascular disease
Lipoprotein(a) (Lp(a)) is associated with atherothrombosis through several mechanisms, including putative antifibrinolytic properties. However,...
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Platelets and extra-corporeal membrane oxygenation in adult patients: a systematic review and meta-analysis
Despite increasing improvement in extracorporeal membrane oxygenation (ECMO) technology and knowledge, thrombocytopenia and impaired platelet...
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Alleviative effect of betaine against copper oxide nanoparticles-induced hepatotoxicity in adult male albino rats: histopathological, biochemical, and molecular studies
BackgroundCopper oxide nanoparticles (CuO-NPs) have gained interest due to their availability, efficiency, and their cost-effectiveness. Betaine is...
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Difference in coagulation systems of large animal species used in cardiovascular research: a systematic review
Preclinical testing using animal models is indispensable in cardiovascular research. However, the translation to clinical practice of these animal...
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Inflammatory cell-associated tumors. Not only macrophages (TAMs), fibroblasts (TAFs) and neutrophils (TANs) can infiltrate the tumor microenvironment. The unique role of tumor associated platelets (TAPs)
It is well known that various inflammatory cells infiltrate cancer cells. Next to TAMs (tumor-associated macrophages), TAFs (tumor-associated...
