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Exploring the feasibility of conducting a randomised controlled trial of group-based pregnancy care and education: a pilot randomised controlled trial in Melbourne, Australia
BackgroundIn group-based pregnancy models, antenatal care and childbirth/parenting education are provided in groups of eight to 10 women, usually...
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Brief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16–18-year-olds: recruitment and baseline characteristics
BackgroundThe Brief Educational Workshops in Secondary Schools Trial (BESST) is an England-wide school-based cluster randomised controlled trial...
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A cluster randomized controlled trial comparing the effectiveness of two school-based interventions for autistic youth with anxiety
BackgroundRecent systematic reviews have indicated that cognitive behavioral therapy (CBT) is effective in reducing anxiety symptoms for autistic and...
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Feasibility and preliminary efficacy of the LEAD trial: a cluster randomized controlled lifestyle intervention to improve hippocampal volume in older adults at-risk for dementia
BackgroundHealthy diet and exercise are associated with reduced risk of dementia in older adults. The impact of diet and exercise interventions on...
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Systematic review of the characteristics of school-based feasibility cluster randomised trials of interventions for improving the health of pupils in the UK
BackgroundThe last 20 years have seen a marked increase in the use of cluster randomised trials (CRTs) in schools to evaluate interventions for...
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Optimising engagement in a digital parenting intervention to prevent violence against adolescents in Tanzania: protocol for a cluster randomised factorial trial
BackgroundViolence against adolescents is a universal reality, with severe individual and societal costs. There is a critical need for scalable and...
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Pragmatic cluster-randomized trial of home-based preventive treatment for TB in Ethiopia and South Africa (CHIP-TB)
BackgroundEach year, 1 million children develop TB resulting in over 200,000 child deaths. TB preventive treatment (TPT) is highly effective in...
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HealthyRHearts - reducing cholesterol in rural adults via telehealth-based medical nutrition therapy: protocol for a cluster randomised controlled trial
BackgroundFew randomised controlled trials specifically focus on prevention in rural populations. Cardiovascular disease (CVD) contributes to...
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Increasing access to fertility preservation for women with breast cancer: protocol for a stepped-wedge cluster randomized trial in France
BackgroundWith the increase in the number of long-term survivors, interest is shifting from cancer survival to life and quality of life after cancer....
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A cluster randomized controlled trial of an electronic decision-support system to enhance antenatal care services in pregnancy at primary healthcare level in Telangana, India: trial protocol
BackgroundIndia contributes 15% of the total global maternal mortality burden. An increasing proportion of these deaths are due to Pregnancy Induced...
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The ACCELERATE Plus (assessment and communication excellence for safe patient outcomes) Trial Protocol: a stepped-wedge cluster randomised trial, cost-benefit analysis, and process evaluation
BackgroundNurses play an essential role in patient safety. Inadequate nursing physical assessment and communication in handover practices are...
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Study protocol: investigating the feasibility of a hybrid delivery of home-based cluster set resistance training for individuals previously treated for lung cancer
BackgroundSymptom burden remains a critical concern for individuals with non-small cell lung cancer (NSCLC) following the completion of treatment....
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Differential posttraumatic stress disorder symptom cluster response to stellate ganglion block: secondary analysis of a randomized controlled trial
Empirically supported treatments for posttraumatic stress disorder (PTSD) exist, but research suggests these therapies are less effective,...
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Increasing the uptake of Intermittent Preventive Treatment of malaria in pregnancy using Sulfadoxine-Pyrimethamine (IPTp-SP) through seasonal malaria chemoprevention channel delivery: protocol of a multicenter cluster randomized implementation trial in Mali and Burkina Faso
BackgroundThe uptake of Intermittent Preventive Treatment of malaria in pregnancy using Sulfadoxine-Pyrimethamine (IPTp-SP) remains unacceptably low,...
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Trial protocol for the Building Resilience through Socio-Emotional Training (ReSET) programme: a cluster randomised controlled trial of a new transdiagnostic preventative intervention for adolescents
BackgroundAdolescence is a period of heightened vulnerability to develo** mental health problems, and rates of mental health disorder in this age...
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Implementing digital devices to increase mobility training for people receiving inpatient rehabilitation: protocol for a feasibility hybrid type II randomized controlled trial
BackgroundPeople with mobility limitations can benefit from rehabilitation programs incorporating intensive, repetitive, and task-specific exercises...
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Evaluation of interventions to prevent vasovagal reactions among whole blood donors: rationale and design of a large cluster randomised trial
BackgroundVasovagal reactions (VVRs) are the most common acute complications of blood donation. Responsible for substantial morbidity, they also...
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A hybrid digital parenting programme to prevent abuse of adolescents in Tanzania: statistical analysis plan for a pragmatic cluster randomised controlled trial
BackgroundGlobally, violence against children poses substantial health and economic challenges, with estimated costs nearing USD 7 trillion. This...
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Peer PrEP referral + HIV self-test delivery for PrEP initiation among young Kenyan women: study protocol for a hybrid cluster-randomized controlled trial
BackgroundOral HIV pre-exposure prophylaxis (PrEP) for HIV prevention is highly effective, but uptake remains low in Africa, especially among young...
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Antenatal couples’ counselling in Uganda (ACCU): study protocol for a randomised controlled feasibility trial
BackgroundCommon avoidable factors leading to maternal, perinatal and neonatal deaths include lack of birth planning (and delivery in an...
