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Prognostic model based on six PD-1 expression and immune infiltration-associated genes predicts survival in breast cancer
BackgroundThe prognosis of breast cancer (BC) was associated with the expression of programmed cell death-1 (PD-1).
MethodsBC-related expression and...
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Estrogen Regulates Scribble Localization in Endometrial Epithelial Cells Through Acyl Protein Thioesterase (APT)-Mediated S-Palmitoylation in Adenomyosis
Despite its prevalence and the severity of symptoms, little is known about the pathogenesis and etiology of adenomyosis. In our previous study,...
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Progress on the Role of Estrogen and Progesterone Signaling in Mouse Embryo Implantation and Decidualization
Embryo implantation and decidualization are key steps in establishing a successful pregnancy. Defects in embryo implantation and decidualization can...
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Establishment of an ovarian cancer exhausted CD8+T cells-related genes model by integrated analysis of scRNA-seq and bulk RNA-seq
Ovarian cancer (OC) was the fifth leading cause of cancer death and the deadliest gynecological cancer in women. This was largely attributed to its...
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Diagnostic and prognostic value of single nucleotide polymorphisms in autophagy-related genes (ATG) among Egyptian patients with breast cancer disease
BackgroundAutophagy-related genes (ATGs), associated with autophagy, contribute to the pathogenesis of many illnesses, including cancer. ATGs’ role...
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Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson’s disease
Parkinson’s disease is characterized by its distinct pathological features; loss of dopamine neurons in the substantia nigra pars compacta and...
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CGB5, INHBA and TRAJ19 Hold Prognostic Potential as Immune Genes for Patients with Gastric Cancer
BackgroundGastric cancer (GC) seriously threatens people’s health and life quality worldwide.
AimThe current study sought to explore prognostic...
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A systems biology approach for investigating significantly expressed genes among COVID-19, hepatocellular carcinoma, and chronic hepatitis B
BackgroundWorldwide, COVID-19’s death rate is about 2%, considering the incidence and mortality. However, the information on its complications in...
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EGR3 and estrone are involved in the tamoxifen resistance and progression of breast cancer
BackgroundTamoxifen (Tam) is an effective treatment for estrogen receptor (ER) positive breast cancer. However, a significant proportion of patients...
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System-level investigation of anti-obesity effects and the potential pathways of Cordyceps militaris in ovariectomized rats
BackgroundCordyceps species have been used as tonics to enhance energy, stamina, and libido in traditional Asian medicine for more than 1600 years,...
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Identification of cervical squamous cell carcinoma feature genes and construction of a prognostic model based on immune-related features
As heterogeneity of cervical squamous cell carcinoma (CSCC), prognosis assessment for CSCC patients remain challenging. To develop novel prognostic...
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Identification of prognostic genes signature and construction of ceRNA network in pirarubicin treatment of triple-negative breast cancer
BackgroundThe altered long non-coding RNA (lncRNA), circular RNA (circRNA) and mRNA expression in triple-negative breast cancer (TNBC) after...
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Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder
BackgroundBipolar disorder (BD) is a multifactorial condition. Several signaling pathways affect development of this disorder. With the purpose of...
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Secoisolariciresinol diglucoside regulates estrogen receptor expression to ameliorate OVX-induced osteoporosis
ObjectiveSecoisolariciresinol diglucoside (SDG) is a phytoestrogen that has been reported to improve postmenopausal osteoporosis (PMOP) caused by...
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RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells
The activity of Rho family GTPase protein, RAC1, which plays important normal physiological functions, is dysregulated in multiple cancers. RAC1 is...
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Looking at Mountains: Role of Sustained Hypoxia in Regulating Bone Mineral Homeostasis in Relation to Wnt Pathway and Estrogen
Deteriorated bone microarchitecture is a major health concern affecting millions worldwide, amounting to high mortality along with psychological,...
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MCM6 Inhibits Decidualization via Cross-Talking with ERK Pathway in Human Endometrial Stromal Cells
Decidualization plays an important role in the implantation of the embryo, but the molecular action implicated in this process is not completely...
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MicroRNA-92a-3p Inhibits Cell Proliferation and Invasion by Regulating the Transcription Factor 21/Steroidogenic Factor 1 Axis in Endometriosis
Endometriosis (EMS) is an estrogen-dependent disease. However, little is known about the regulation of estrogen, a potential therapeutic target, in...
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Kruppel-like factor 5 (Klf5) in fetal-maternal tissue during periimplantation and effects of ovarian steroid hormone antagonist on its expression during uterine receptivity of albino mice
BackgroundEmbryo implantation is a tightly regulated sequence of events regulated by ovarian steroids, estrogen and progesterone, and their...
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Integration of peripheral transcriptomics, genomics, and interactomics following trauma identifies causal genes for symptoms of post-traumatic stress and major depression
Posttraumatic stress disorder (PTSD) is a debilitating syndrome with substantial morbidity and mortality that occurs in the aftermath of trauma....
