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Immunohistochemical markers of prognosis in adult granulosa cell tumors of the ovary – a review
BackgroundGranulosa cell tumors (GCT) are rare malignant ovarian tumors. The two subtypes, adult and juvenile granulosa cell tumors, differ in...
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TRAF4 hyperactivates HER2 signaling and contributes to Trastuzumab resistance in HER2-positive breast cancer
The HER2 receptor modulates downstream signaling by forming homodimers and heterodimers with other members of the HER family. For patients with...
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Clinical observational study on the efficacy of induction chemotherapy sequential concurrent radiotherapy combined with targeted therapy in patients with locally advanced EGFR-positive nasopharyngeal carcinoma: prediction model construction and efficacy testing
ObjectiveTo establish a nomogram for prediction of prognosis in EGFR-positive advanced nasopharyngeal carcinoma (NPC) patients who were treated with...
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Clinical response to adding pyrotinib to pembrolizumab and lenvatinib for HER2-positive advanced intrahepatic cholangiocarcinoma: a case report
BackgroundIntrahepatic cholangiocarcinoma (ICC) is a highly lethal hepatobiliary cancer, and very few patients can undergo surgery. The prognosis of...
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Radioresistance or/and radiosensitivity of head and neck squamous cell carcinoma: biological angle
ObjectiveThis narrative review aimed to compile and summarize clinically relevant literature in radiation therapy and to discuss the potential in...
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Safety and Tolerability of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors in Oncology
Tyrosine kinase inhibitors (TKIs) that target epidermal growth factor receptor (EGFR) have dramatically improved progression-free survival in...
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Potent anti-tumor immune response and tumor growth inhibition induced by HER2 subdomain fusion protein in a mouse tumor model
PurposeSeveral approaches have so far been employed to establish anti-tumor immunity by targeting HER2 protein. Active immunization with recombinant...
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Himalayan flora: targeting various molecular pathways in lung cancer
The fatal amplification of lung cancer across the globe and the limitations of current treatment strategies emphasize the necessity for substitute...
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A pharmacological exploration of targeted drug therapy in non-small cell lung cancer
Lung cancer is the prime cause of cancer-related deaths globally, with a contribution of 85% from non-small cell lung cancer. Before a few decades...
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Apatinib exhibits synergistic effect with pyrotinib and reverses acquired pyrotinib resistance in HER2-positive gastric cancer via stem cell factor/c-kit signaling and its downstream pathways
BackgroundRecently, progress has been made in the development of targeted therapies for human epidermal growth factor receptor 2 (HER2)-positive...
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Clinical characteristics and prognostic factors of patients with non-small cell lung cancer having HER2 alterations
PurposeHuman epidermal growth factor 2 (HER2) alterations are found in approximately 2%–5% of non-small cell lung cancer (NSCLC). This study aimed to...
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How to Optimise Extended Adjuvant Treatment with Neratinib for Patients with Early HER2+ Breast Cancer
Over the last 20 years, treatment of patients with human epidermal growth factor receptor 2-positive (HER2+) early breast cancer has considerably...
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Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME), and cancer-associated fibroblasts (CAFs) in TME are critical...
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Progression from ductal carcinoma in situ to invasive breast cancer: molecular features and clinical significance
Ductal carcinoma in situ (DCIS) represents pre-invasive breast carcinoma. In untreated cases, 25–60% DCIS progress to invasive ductal carcinoma...
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Molecular and functional imaging in cancer-targeted therapy: current applications and future directions
Targeted anticancer drugs block cancer cell growth by interfering with specific signaling pathways vital to carcinogenesis and tumor growth rather...
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Breast cancer immunotherapy: a comprehensive review
Cancer remains a major health problem despite numerous new medical interventions that have been introduced in recent years. One of the major choices...
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Comparing protein and mRNA expressions of the human epidermal growth factor receptor family in estrogen receptor-positive breast cancer
The human epidermal growth factor receptor (HER) family plays a vital role in the development of resistance to treatments in estrogen receptor...
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Targeting Angiogenic Factors for the Treatment of Medulloblastoma
Medulloblastoma (MB) is the most frequent pediatric brain tumor. Despite conventional therapy, MB patients have high mortality and morbidity rates...
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MASTL regulates EGFR signaling to impact pancreatic cancer progression
Pancreatic cancer (PC) remains a major cause of cancer-related deaths primarily due to its inherent potential of therapy resistance. Checkpoint...
