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Underlying mechanisms and cardioprotective effects of SGLT2i and GLP-1Ra: insights from cardiovascular magnetic resonance
Originally designed as anti-hyperglycemic drugs, Glucagon-Like Peptide-1 receptor agonists (GLP-1Ra) and Sodium-glucose cotransporter-2 inhibitors...
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The non-invasive assessment of myocardial work by pressure-strain analysis: clinical applications
Pressure–volume (PV) analysis is the most comprehensive way to describe cardiac function, giving insights into cardiac mechanics and energetics....
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Relationships of high cardiac output with ventricular morphology, myocardial energetics, and energy costs in hemodialysis patients with preserved ejection fraction
Hemodialysis patients have conditions that increase cardiac output (CO), including arteriovenous fistula, fluid retention, vasodilator use, and...
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Chaperone-mediated autophagy promotes PCa survival during ARPI through selective proteome remodeling
The androgen receptor (AR) plays an important role in PCa metabolism, with androgen receptor pathway inhibition (ARPI) subjecting PCa cells to acute...
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Cardiac 31P MR spectroscopy: development of the past five decades and future vision—will it be of diagnostic use in clinics?
In the past five decades, the use of the magnetic resonance (MR) technique for cardiovascular diseases has engendered much attention and raised the...
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Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder
There is increasing interest in individualizing treatment selection for more than 25 regulatory approved treatments for major depressive disorder...
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Cardiac metabolic remodelling in chronic kidney disease
Chronic kidney disease (CKD) affects millions of people globally and, for most patients, the risk of develo** cardiovascular disease is higher than...
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Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer
In 2021, breast cancer accounted for a substantial proportion of cancer cases and represented the second leading cause of cancer deaths among women...
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Myocardial transcriptomic analysis of diabetic patients with aortic stenosis: key role for mitochondrial calcium signaling
BackgroundType 2 diabetes (T2D) is a frequent comorbidity encountered in patients with severe aortic stenosis (AS), leading to an adverse left...
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Antioxidant evaluation and computational prediction of prospective drug-like compounds from polyphenolic-rich extract of Hibiscus cannabinus L. seed as antidiabetic and neuroprotective targets: assessment through in vitro and in silico studies
BackgroundReports have implicated diabetes mellitus (DM) and Alzheimer’s disease (AD) as some of the global persistent health challenges with no...
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4-hydroxytamoxifen does not deteriorate cardiac function in cardiomyocyte-specific MerCreMer transgenic mice
Conditional, cell-type-specific transgenic mouse lines are of high value in cardiovascular research. A standard tool for cardiomyocyte-restricted DNA...
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Effects of tissue degradation by collagenase and elastase on the biaxial mechanics of porcine airways
BackgroundCommon respiratory illnesses, such as emphysema and chronic obstructive pulmonary disease, are characterized by connective tissue damage...
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Left ventricular myocardial work for the prediction of postoperative outcomes in patients with bicuspid aortic stenosis
Chronic elevation of left ventricular (LV) afterload contributes to adverse LV remodeling and myocardial impairment in bicuspid aortic valve (BAV)...
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Impaired Myocardial Work in Children with Hypertrophic Cardiomyopathy and Left Ventricular Fibrosis on Cardiac Magnetic Resonance Imaging
Echocardiography is pivotal for diagnosis and monitoring of hypertrophic cardiomyopathy (HCM) and can evaluate myocardial function using myocardial...
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Chlordiazepoxide against signalling, receptor and regulatory proteins of breast cancer: a structure-based in-silico approach
Among the most prevalent forms of cancer are breast, lung, colon-rectum, and prostate cancers, and breast cancer is a major global health challenge,...
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Are antibacterial effects of non-antibiotic drugs random or purposeful because of a common evolutionary origin of bacterial and mammalian targets?
PurposeAdvances in structural biology, genetics, bioinformatics, etc. resulted in the availability of an enormous pool of information enabling the...
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Pathophysiology and Treatment Opportunities of Iron Deficiency in Heart Failure: Is There a Need for Further Trials?
Purpose of ReviewIron deficiency (ID) complicates heart failure (HF) at different stages of the natural history of the disease; however, this...
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