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Explore the alterations of downstream molecular pathways caused by ARID1A mutation/knockout in human endometrial cancer cells
PurposeAs one of the most common gynecologic malignancies, endometrial cancer (EC) is driven by multiple genetic alterations that may be targeted for...
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Molecular-based classification of endometrial carcinoma in Northern Thailand: impact on prognosis and potential for implementation in resource-limited settings
BackgroundEndometrial carcinoma is molecularly categorized into four subgroups: polymerase-E exonuclease domain-mutant (POLE-mut), mismatch...
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vNOTES surgical staging for endometrial carcinoma in overweight patients: a case series
ObjectivesThe purpose of this study is to show the feasibility and surgical outcome of vNOTES retroperitoneal dissection and isolation of sentinel...
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Clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive age
BackgroundWe aimed to explore the clinical and metabolic characteristics in polycystic ovary syndrome (PCOS) patients with different endometrial...
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Association of tet methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in endometrioid adenocarcinoma and its clinical significance
BackgroundAberrant DNA methylation is a vital molecular alteration commonly detected in type I endometrial cancers (EC), and tet methylcytosine...
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Non-invasive Differentiation of Endometrial Adenocarcinoma from Benign Lesions in the Uterus by Utilization of Amide Proton Transfer-Weighted MRI
PurposeTo evaluate the utility of three-dimensional (3D) amide proton transfer-weighted (APTw) imaging for differentiation of endometrial...
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Single Institute Experience with Neo-Adjuvant Chemotherapy and Interval Debulking Surgery in Advanced Endometrial Cancer
Our study aims to review the role of neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) in patients with advanced...
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Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer
PurposeChanges in the activity of endothelins and their receptors may promote neoplastic processes. They can be caused by epigenetic modifications...
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Treatment of node-positive endometrial cancer: chemotherapy, radiation, immunotherapy, and targeted therapy
The standard of treatment for node-positive endometrial cancer (FIGO Stage IIIC) in North America has been systemic therapy with or without...
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Steerable DROP-IN radioguidance during minimal-invasive non-robotic cervical and endometrial sentinel lymph node surgery
PurposeThe recently introduced tethered DROP-IN gamma probe has revolutionized the way robotic radioguided surgery is performed, fully exploiting the...
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Establishing and Validating an Innovative Focal Adhesion-Linked Gene Signature for Enhanced Prognostic Assessment in Endometrial Cancer
AbstractStudies have highlighted the significant role of focal adhesion signaling in cancer. Nevertheless, its specific involvement in the...
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Mesonephric-like adenocarcinoma of the ovary
Mesonephric-like adenocarcinoma is a new class of rare subtypes of the female reproductive system. Its clinical symptoms are similar to other types...
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High-Grade Endometrial Cancer: Molecular Subtypes, Current Challenges, and Treatment Options
Although many recent advancements have been made in women’s health, perhaps one of the most neglected areas of research is the diagnosis and...
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JGOG2046: a feasibility study of neoadjuvant chemotherapy followed by debulking surgery for clinically diagnosed FIGO stage IVb endometrial cancer
BackgroundWe evaluated the feasibility of neoadjuvant chemotherapy, followed by debulking surgery, for clinically diagnosed FIGO stage IVb...
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Trends in incidence and hormonal management of endometrial cancer during potentially reproductive age in Japan: a population-based study
BackgroundWe aimed to investigate the trends in the incidence and treatment of endometrial cancer (EC) during potentially reproductive age in Japan,...
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Lymph node evaluation for endometrial hyperplasia: a nationwide analysis of minimally invasive hysterectomy in the ambulatory setting
BackgroundGiven the possibility of occult endometrial cancer where nodal status confers important prognostic and therapeutic data, role of lymph node...
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Metabolic syndrome is an independent risk factor for time to complete remission of fertility-sparing treatment in atypical endometrial hyperplasia and early endometrial carcinoma patients
ObjectiveFertility-sparing treatment of atypical endometrial hyperplasia (AEH) and early endometrial carcinoma (EC) patients has recently emerged...
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The role of diffusion magnetic resonance imaging in determining tumor aggressiveness during preoperative surgical planning in early-stage endometrial cancer
PurposeThe present study aimed to evaluate the relationship between tumor volume and apparent diffusion coefficient (ADC) in preoperative magnetic...
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Radiomics-based fertility-sparing treatment in endometrial carcinoma: a review
In recent years, with the increasing incidence of endometrial carcinoma in women of child-bearing age, to decision of whether to preserve patients’...
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Predicting Risk Stratification in Early-Stage Endometrial Carcinoma: Significance of Multiparametric MRI Radiomics Model
Endometrial carcinoma (EC) risk stratification prior to surgery is crucial for clinical treatment. In this study, we intend to evaluate the...
