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Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia
Despite high initial response rates, acute myeloid leukemia (AML) treated with the BCL-2–selective inhibitor venetoclax (VEN) alone or in...
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Could Hydroxocobalamin Be of Use in the Treatment of Lactate Acidosis Induced by Propofol Infusion Syndrome? - A Case Report
Review of the literature shows no standard of care for the treatment of propofol infusion syndrome. Our case shows a potential therapeutic approach...
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Proteomic analysis of gene expression in the prefrontal cortex in infant rhesus macaques after multiple sevoflurane exposures
PurposeRepeated exposure of infant rhesus macaques to sevoflurane induces neurotoxicity and is associated with neurocognitive impairment in later...
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Heavy chain deposition disease presenting with raised anti-GBM antibody levels; a case report
BackgroundMonoclonal immunoglobulin deposition disease (MIDD) is a rare condition accounting for < 1% of histopathological diagnoses made on kidney...
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Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy
The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits,...
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Defects in syntabulin-mediated synaptic cargo transport associate with autism-like synaptic dysfunction and social behavioral traits
The formation and maintenance of synapses require long-distance delivery of newly synthesized synaptic proteins from the soma to distal synapses,...
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Implications of mitochondrial DNA variants in pediatric B-cell acute lymphoblastic leukemia
BackgroundResearch on the role of variations in the mitochondrial genome in pathogenesis of acute lymphoblastic leukemia (ALL) has been unfolding at...
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Acacetin alleviates autoimmune myocarditis by regulating CD4+ T cell mitochondrial respiration
BackgroundMyocarditis refers to an autoimmune inflammatory response of the myocardium with characterization of self-reactive CD4+ T cell activation,...
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Hepatocellular carcinoma stage: an almost loss of fatty acid metabolism and gain of glucose metabolic pathways dysregulation
Cancer cells rewire the metabolic processes beneficial for cancer cell proliferation, survival, and their progression. In this study, metabolic...
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Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells
BackgroundMitochondrial dysfunction is a hallmark of both critical illness and propofol infusion syndrome and its severity seems to be proportional...
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New insights into the nutritional genomics of adult-onset riboflavin-responsive diseases
Riboflavin, or vitamin B2, is an essential nutrient that serves as a precursor to flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN)....
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Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in develo** cardiomyocytes
A deficiency of striated preferentially expressed gene ( Speg ), a member of the myosin light chain kinase family, results in abnormal myofibril...
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A gene co-expression module implicating the mitochondrial electron transport chain is associated with long-term response to lithium treatment in bipolar affective disorder
Lithium is the first-line treatment for bipolar affective disorder (BPAD) but two-thirds of patients respond only partially or not at all. The...
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Effect of human umbilical cord mesenchymal stem cell exosomes on aerobic metabolism of human retinal pigment epithelial cells
PurposeTo investigate the effect of exosomes secreted by human umbilical cord mesenchymal stem cells (HUCMSC-Exo) on aerobic metabolism of cobalt...
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Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis
Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in amyotrophic lateral sclerosis (ALS), where the key pathological...
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SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation
SMYD1, a striated muscle-specific lysine methyltransferase, was originally shown to play a key role in embryonic cardiac development but more...
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FAM3A Deficiency − Induced Mitochondrial Dysfunction Underlies Post-Infarct Mortality and Heart Failure
Mitochondrial protein sequence similarity 3 gene family member A (FAM3A) plays important roles in the electron transfer chain, while its functions in...
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Advances in Metabolic Remodeling and Intervention Strategies in Heart Failure
The heart is the most energy-demanding organ throughout the whole body. Perturbations or failure in energy metabolism contributes to heart failure...
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Novel mitochondrial tRNALeu(UUR) 3261A > g mutation in two pedigrees with essential hypertension
BackgroundEssential hypertension (EH) was associated with mitochondrial tRNA mutations.
AimsThis study was designed to assess the association...
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Electroacupuncture Alleviates Functional Constipation in Mice by Activating Enteric Glial Cell Autophagy via PI3K/AKT/mTOR Signaling
ObjectiveTo investigate autophagy-related mechanisms of electroacupuncture (EA) action in improving gastrointestinal motility in mice with functional...