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Breaking the ice to improve motor outcomes in patients with chronic stroke: a retrospective clinical study on neuromodulation plus robotics
BackgroundStroke is one of the main causes of impairment affecting daily activities and quality of life. There is a growing effort to potentiate the...
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Uptake of pharmacist recommendations by patients after discharge: Implementation study of a patient-centered medicines review service
BackgroundPolypharmacy and potentially inappropriate medicine use is common in older people, resulting in harm increased by lack of patient-centred...
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Interpreting the efficacy enhancement mechanism of Chinese medicine processing from a biopharmaceutic perspective
Chinese medicine processing (CMP) is a unique pharmaceutical technology that distinguishes it from natural medicines. Current research primarily...
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Synaptic plasticity mechanisms behind TMS efficacy: insights from its application to animal models
Neural plasticity is defined as a reshape of communication paths among neurons, expressed through changes in the number and weights of synaptic...
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Pain inhibition—the unintended benefit of electrically elicited muscle strengthening contractions
BackgroundNeuromuscular electrical stimulation (NMES) is effective in muscle strengthening after orthopedic injury particularly when muscle...
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Sun exposure reduction by melanoma survivors with wearable sensor providing real-time UV exposure and daily text messages with structured goal setting
Despite knowledge of subsequent melanoma risk and the benefit of sun protection in risk reduction, melanoma survivors often do not engage in adequate...
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Abnormal connectivity model of raphe nuclei with sensory-associated cortex in Parkinson’s disease with chronic pain
Background and ObjectiveThere are indicates that raphe nuclei may be involved in the occurrence of chronic pain in Parkinson’s disease (PD). In the...
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Central sensitization in adolescents with hypermobility spectrum disorder or hypermobile Ehlers-Danlos syndrome—a feasibility study
BackgroundPain is a major symptom in adolescents with hypermobility spectrum disorder or hypermobile Ehlers-Danlos syndrome. Although the underlying...
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Persistent hemiplegia with normal intraoperative neurophysiological monitoring in supratentorial neurosurgery: a case report and review of literature
Intraoperative neurophysiological monitoring (IONM) is needed for evaluating and demonstrating the integrity of the central and peripheral nervous...
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Translation, cross-cultural adaptation and measurement proprieties of the German version of the Allodynia Symptom Checklist (ASC-12)
BackgroundCutaneous allodynia is highly prevalent among migraineurs and is associated with a poor prognosis. The Allodynia Symptom Checklist (ASC-12)...
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Assessment, pharmacological therapy and rehabilitation management of musculoskeletal pain in children with mucopolysaccharidoses: a sco** review
BackgroundPain of musculoskeletal origin is very common in young patients affected by Mucopolysaccharidoses. This sco** review evaluates the...
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Beyond treatment of chronic pain: a sco** review about epidural electrical spinal cord stimulation to restore sensorimotor and autonomic function after spinal cord injury
Epidural electrical epinal cord stimulation (ESCS) is an established therapeutic option in various chronic pain conditions. In the last decade,...
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Acceptance and self-reported use of a dementia care toolbox by general practice personal: results from an intervention study in German practices
BackgroundDementia is an age-related syndrome that is estimated to affect 46.8 million people worldwide (2015). In ageing populations, the prevalence...
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Accurate diagnosis and effective treatment of abnormal meridians in erectile dysfunction patients based on infrared thermography: an electrophysiological technique study
AbstractAn increasing body of research has demonstrated that appropriate stimulation of the meridians and acupoints in the human body can play a...
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A controlled randomized trial with a 12-week follow-up investigating the effects of medium-frequency neuromuscular electrical stimulation on pain, VMO thickness, and functionality in patients with knee osteoarthritis
BackgroundOne of the major contributors to disability in Knee osteoarthritis (KOA) patients is weakness in the Quadriceps Femoris muscle....
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Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling
Opioids are the frontline analgesics for managing various types of pain. Paradoxically, repeated use of opioid analgesics may cause an exacerbated...
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Central stress pathways in the development of cardiovascular disease
PurposeMental stress is of essential consideration when assessing cardiovascular pathophysiology in all patient populations. Substantial evidence...
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Hospitalizations and re-hospitalizations at the end-of-life among cancer patients; a retrospective register data study
BackgroundPatients with incurable cancer are frequently hospitalized within their last 30 days of life (DOL) due to numerous symptoms and concerns....
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Circadian Rhythm and Pain: a Review of Current Research and Future Implications
Purpose of ReviewThe goal is to examine the link between circadian rhythms and pain, which may shed further light on improving pain management...
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Multimodal assessment of motor pathways and intracortical connections in functional hemispherectomy
PurposeFor selected children with medically intractable epilepsy, hemispherectomy can be an excellent treatment option and its efficacy in achieving...
