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Die Effekte der Herz-Lungen-Maschine auf das intestinale Mikrobiom und die Relation zum postoperativen SIRS
Cardiopulmonary bypass (CPB) made cardiac surgery possible. Despite its almost 70 years of existence and countless design improvements, it still...
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Einsatz vollkontinuierlicher Modelle zur biostatistischen Bewertung forensischer DNA-analytischer Befunde
The biostatistical evaluation of DNA profiles supports the courts in the assessment of the evidential value of a DNA stain. In practice, an...
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CAR-T-Zellen als Arzneimittel für neuartige Therapien (Advanced Therapy Medicinal Products)
BackgroundTwo commercial chimeric antigen receptor (CAR) T cell products, axicabtagene-ciloleucel (Yescarta®) and tisagenlecleucel (Kymriah®), are...
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Hepatitis B und C: Mechanismen der virusinduzierten Leberpathogenese und Tumorentstehung
Worldwide, the hepatitis B and hepatitis C viruses (HBV, HCV) are the most relevant causative viral agents of a chronic hepatitis (inflammation of...
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Immunhistochemische Analyse einer Hypoxie-assoziierten Signatur in Melanomen mit positivem und negativem Schildwächterlymphknoten
Metabolic reprogramming mediated by hypoxia-inducible factors and its downstream targets plays a crucial role in many human malignancies. Excessive...
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Genomik und Proteomik in der Erforschung neuromuskulärer Erkrankungen
Neurological diseases affect 3–5% of children and, apart from cardiovascular diseases and cancer, represent the most prominent cause of morbidity and...
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Genetik und personalisierte Medizin bei Asthma bronchiale
Asthma is a frequent and heterogeneous, chronic inflammatory disease of the airways in which genetic and epigenetic mechanisms play a role in disease...
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Nutzung von Altersinformationen aus posttranslationalen Proteinmodifikationen und DNA-Methylierung zur postmortalen Lebensaltersschätzung
The identification and description of “molecular clocks” (posttranslational protein modifications, DNA methylation) offer new possibilities for the...
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Neue Antikörper in der Diagnostik
Rheumatologists were pivotal in the development of using autoantibodies to diagnose chronic inflammatory diseases. Rheumatoid factors were already...
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Cisplatinrefraktäre Keimzelltumoren – molekulare Grundlagen und klinische Konzepte
BackgroundDespite excellent cure rates due to platinum-based combination chemotherapy in advanced stages, 10–15% of germ cell tumour (GCT) patients...
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Tumorbiologie des Oropharynxkarzinoms
BackgroundEtiologically, oropharyngeal squamous cell carcinoma (OPSCC) can be divided into OPSCC caused by noxious agents and human papillomavirus...
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„Errare humanum est“? Selbstbildung und Subjektivierung durch Fehlleistung
Freud’s research on errors was not a therapeutic issue but was motivated by an interest in the “human, all-too-human” condition and the search for...
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Kausale Therapie der Alzheimer-Krankheit: Amyloidantikörper
BackgroundAlzheimerʼs disease (AD) is the most common cause of dementia. The number of people affected will increase dramatically in the coming...
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Multiple Sklerose: Infektionsprophylaxe und Impfungen
In multiple sclerosis, highly effective disease-modifying therapies are associated with the risk of infectious diseases, and substance-specific...