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Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis
BackgroundClear cell renal cell carcinoma (ccRCC), the most common pathological subtype of kidney cancer, accounts for approximately 70% to 80% of...
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Characterization of extrachromosomal circular DNAs in plasma of patients with clear cell renal cell carcinoma
Background and PurposeExtrachromosomal circular DNAs (eccDNAs) have been recognized for their significant involvement in numerous biological...
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Dual-loss of PBRM1 and RAD51 identifies hyper-sensitive subset patients to immunotherapy in clear cell renal cell carcinoma
BackgroundHomologous recombination deficiency (HRD), though largely uncharacterized in clear cell renal cell carcinoma (ccRCC), was found associated...
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P4HA3 promotes clear cell renal cell carcinoma progression via the PI3K/AKT/GSK3β pathway
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma. P4HA3 is a key enzyme in collagen biosynthesis and has...
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NUF2 is correlated with a poor prognosis and immune infiltration in clear cell renal cell carcinoma
BackgroundClear cell renal cell carcinoma (ccRCC) is one of the most common malignancies. Recently, immunotherapy has been considered a promising...
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Low expression of SLC34A1 is associated with poor prognosis in clear cell renal cell carcinoma
ObjectiveClear cell renal cell carcinoma (ccRCC) is a malignant renal tumor that is highly prone to metastasis and recurrence. The exact pathogenesis...
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Integrated analysis of the roles of oxidative stress related genes and prognostic value in clear cell renal cell carcinoma
BackgroundPatients with clear cell renal cell carcinoma (ccRCC), which is the most commonly diagnosed subtype of renal cell carcinoma, are at risk of...
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Serum extracellular vesicles derived hsa-miR-320d as an indicator for progression of clear cell renal cell carcinoma
BackgroundRenal cell carcinoma (RCC) is a prevalent malignancy with a rising incidence in develo** countries. Clear cell renal cell carcinoma...
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Machine learning-driven prognostic analysis of cuproptosis and disulfidptosis-related lncRNAs in clear cell renal cell carcinoma: a step towards precision oncology
Cuproptosis and disulfidptosis, recently discovered mechanisms of cell death, have demonstrated that differential expression of key genes and long...
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Association of sex-specific abdominal adipose tissue with WHO/ISUP grade in clear cell renal cell carcinoma
ObjectivesTo explore the association between computed tomography (CT)-measured sex-specific abdominal adipose tissue and the pathological grade of...
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Anemia in patients ≥ 75 years with metastatic clear cell renal cell carcinoma: an important poor prognostic factor in the international metastatic renal cell carcinoma database consortium model
BackgroundDue to an increase in life expectancy, the incidence of metastatic renal cell carcinoma (mRCC) in patients aged ≥75 years has been...
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Construction of cuproptosis signature based on bioinformatics and experimental validation in clear cell renal cell carcinoma
BackgroundCuproptosis was defined as a novel nonapoptotic cell death pathway and its potential function in clear cell renal cell carcinoma (ccRCC)...
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Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
ObjectiveThe latest research proposed a novel copper-dependent programmed cell death named cuproptosis. We aimed to elucidate the influence of...
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Development and validation of a nomogram to predict recurrence for clinical T1/2 clear cell renal cell carcinoma patients after nephrectomy
ObjectiveTo develop and validate a nomogram for predicting recurrence-free survival (RFS) for clinical T1/2 (cT1/2) clear cell renal cell carcinoma...
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Associations between contrast-enhanced ultrasound features and WHO/ISUP grade of clear cell renal cell carcinoma: a retrospective study
BackgroundClear cell renal cell carcinoma (CCRCC) comprises 70%–80% of RCCs. The World Health Organization/International Society of Urology Pathology...
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Construction of the metabolic reprogramming-associated gene signature for clear cell renal cell carcinoma prognosis prediction
BackgroundMetabolism reprogramming is a hallmark that associates tumor growth, metastasis, progressive, and poor prognosis. However, the...
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ATAD2 promotes glycolysis and tumor progression in clear cell renal cell carcinoma by regulating the transcriptional activity of c-Myc
Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urogenital tract. Given that ccRCC is often resistant to radiotherapy and...
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A CT-based deep learning radiomics nomogram outperforms the existing prognostic models for outcome prediction in clear cell renal cell carcinoma: a multicenter study
ObjectivesTo develop and validate a CT-based deep learning radiomics nomogram (DLRN) for outcome prediction in clear cell renal cell carcinoma...
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ImmunoPET/CT imaging of clear cell renal cell carcinoma with [18F]RCCB6: a first-in-human study
PurposeThe cluster of differentiation (CD70) is a potential biomarker of clear cell renal cell carcinoma (ccRCC). This study aims to develop...
