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Circulating Tumor DNA in Diffuse Large B-Cell Lymphoma: from Bench to Bedside?
Diffuse large B-cell lymphoma (DLBCL) is a curable disease with variable outcomes due to underlying heterogeneous clinical and molecular...
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Efficacy relevance of PD-L1 expression on circulating tumor cells in metastatic breast cancer patients treated with anti-PD-1 immunotherapy
PurposeBreast cancer has become the leading cause of cancer mortality in women. Although immune checkpoint inhibitors targeting programmed death-1...
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Association of survivin positive circulating tumor cell levels with immune escape and prognosis of osteosarcoma
PurposeFunction of survivin protein (encoded by BIRC5) in circulating tumor cells (CTCs) of osteosarcoma (OS) has not been investigated. The goal of...
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Circulating tumor cells, circulating tumor DNA, and disease characteristics in young women with metastatic breast cancer
BackgroundClinical and genomic data from patients with early-stage breast cancer suggest more aggressive disease in premenopausal women. However, the...
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Circulating Tumor DNA in Lymphoma
Purpose of ReviewRecent advances have been made in circulating tumor DNA (ctDNA), the method to minimally invasive detect lymphoma sensitively with...
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Specific lineage transition of tumor-associated macrophages elicits immune evasion of ascitic tumor cells in gastric cancer with peritoneal metastasis
BackgroundGastric cancer with peritoneal metastasis (PM-GC), recognized as one of the deadliest cancers. However, whether and how the tumor...
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Influence of opioid analgesia type on circulating tumor cells in open colorectal cancer surgery (POACC-1): study protocol for a prospective randomized multicenter controlled trial
BackgroundOpioids and epidural analgesia are a mainstay of perioperative analgesia but their influence on cancer recurrence remains unclear. Based on...
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Impact of endoscopic metallic stent placement and emergency surgery on detection of viable circulating tumor cells for acute malignant left-sided colonic obstruction
BackgroundSelf-expanding metal stents (SEMS) served as a bridge to surgery (BTS). However, this method may be associated with worse long-term...
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Whole-exome sequencing reveals the metastatic potential of hepatocellular carcinoma from the perspective of tumor and circulating tumor DNA
BackgroundRelapse of hepatocellular carcinoma (HCC) due to vascular invasion is common, but the genomic mechanisms remain unclear, and molecular...
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Tumor Burden Monitoring with Circulating Tumor DNA During Treatment in Patients with Esophageal Squamous Cell Carcinoma
BackgroundTo guide appropriate treatment strategy, an accurate tumor monitoring modality that reflects tumor burden during neoadjuvant treatment is...
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Use of Circulating Tumor DNA to Guide Decision-making in Adjuvant Colon Cancer
Purpose of ReviewThe use of circulating tumor DNA (ctDNA) assays to guide clinical decision-making in early-stage colon cancer is an area of rapidly...
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Searching for the “Holy Grail” of breast cancer recurrence risk: a narrative review of the hunt for a better biomarker and the promise of circulating tumor DNA (ctDNA)
BackgroundThis paper is a narrative review of a major clinical challenge at the heart of breast cancer care: determining which patients are at risk...
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Circulating tumour cells for early detection of clinically relevant cancer
Given that cancer mortality is usually a result of late diagnosis, efforts in the field of early detection are paramount to reducing cancer-related...
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Short-term serial circulating tumor DNA assessment predicts therapeutic efficacy for patients with advanced pancreatic cancer
PurposeWe investigated the potential clinical utility of short-term serial KRAS -mutated circulating cell-free tumor DNA (ctDNA) assessment for...
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Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer
PurposeCurrent clinical prognostic factors are not accurate enough to identify and monitor those muscle-invasive bladder cancer (MIBC) patients at...
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Variant allele frequency in circulating tumor DNA correlated with tumor disease burden and predicted outcomes in patients with advanced breast cancer
PurposeIn patients with first-line advanced breast cancer (ABC), the correlation between ctDNA variant allele frequency (VAF) and tumor disease...
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Predictive value of circulating tumor cell counts during the treatment of cancer: interactions with the blood microenvironment
ObjectiveThis study aimed to evaluate the prognostic value of circulating tumor cell (CTC) in tumor patients during treatment.
Methods ...
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Diagnosis of colorectal cancer based on folate receptor-positive circulating tumor cell analysis: a retrospective cohort study
BackgroundEarly diagnosis and treatment are crucial to improve the prognosis of colorectal cancer (CRC). At present, there is a lack of an accurate...
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Bridging horizons beyond CIRCULATE-Japan: a new paradigm in molecular residual disease detection via whole genome sequencing-based circulating tumor DNA assay
Circulating tumor DNA (ctDNA) is the fraction of cell-free DNA in patient blood that originates from a tumor. Advances in DNA sequencing technologies...
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Early Circulating Tumor DNA Dynamics Predict Neoadjuvant Therapy Response and Recurrence in Colorectal Liver Metastases: A Prospective Study
BackgroundFor patients with colorectal liver metastases (CRLM) who receive neoadjuvant therapy (NAT), reliable indicators that can early and...
