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HIV-1 transgene expression in rats induces differential expression of tumor necrosis factor alpha and zinc transporters in the liver and the lung
BackgroundHighly effective antiviral treatment can suppress HIV-1 infection, but the chronic effects of HIV-1-related viral proteins, including gp120...
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Three-dimensional structure of β-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W
BackgroundWe examined the effects of the R325W mutation on the three-dimensional (3D) structure of the β-cell-specific Zn 2+ (zinc) transporter ZnT-8.
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Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
Aims/hypothesisZinc is highly concentrated in pancreatic beta cells, is critical for normal insulin storage and may regulate glucagon secretion from...
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Efflux-Mediated Drug Resistance in Bacteria
Drug efflux pumps play a key role in drug resistance and also serve other functions in bacteria. There has been a growing list of multidrug and...