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Beyond histology: A tissue algorithm predictive of post-surgical recurrence in hepatocellular carcinomas, including TERT promoter mutation
Surgical resection for hepatocellular carcinoma (HCC) is burdened with a high recurrence rate and a lack of reliable prognostic factors. The aim of...
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Cordycepin improves sensitivity to temozolomide in glioblastoma cells by down-regulating MYC
PurposeGlioblastoma is one of the malignant tumors with poor prognosis and no effective treatment is available at present.
MethodsTo study the...
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High Prevalence of DICER1 Mutations and Low Frequency of Gene Fusions in Pediatric Follicular-Patterned Tumors of the Thyroid
Follicular-patterned tumors of the thyroid in the adult population frequently harbor RAS mutations or PAX8-PPARG rearrangement, but little is known...
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Genetic-driven biomarkers for liver fibrosis through bioinformatic approach
BackgroundLiver fibrosis is a widespread chronic liver ailment linked to substantial mortality and limited therapeutic options. An in-depth...
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An immune-related biomarker index for predicting the effectiveness of immunotherapy and prognosis in hepatocellular carcinoma
ObjectiveCurrently, there are no recognized biomarkers for predicting the immunotherapy response and prognosis of hepatocellular carcinoma (HCC)....
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Quantitative radiomics and qualitative LI-RADS imaging descriptors for non-invasive assessment of β-catenin mutation status in hepatocellular carcinoma
PurposeGain-of-function mutations in CTNNB1 , gene encoding for β-catenin, are observed in 25–30% of hepatocellular carcinomas (HCCs). Recent studies...
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Characterization of stem cell subtypes and prognostic signature in hepatocellular carcinoma
BackgroundCancer stem cells (CSCs) were linked to cancer aggressiveness and poor prognosis in patients with hepatocellular carcinoma (HCC).
...
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Novel CTNNB1-USP6 fusion in intravascular fasciitis of the large vein identified by next-generation sequencing
Intravascular fasciitis (IVF) is considered a rare variant of nodular fasciitis, which often involves small- and medium-sized blood vessels....
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PBRM1 and BAP1: novel genetic mutations in malignant transformation of craniopharyngioma—a case report
Malignant craniopharyngioma is especially rare, so the causes and genetic mutations associated with the malignant transformation have not been...
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Pseudoendocrine sarcoma: clinicopathologic, molecular, and epigenetic features of one case
Pseudoendocrine sarcoma (PES) is a recently described neoplasm typically arising in paravertebral soft tissues. Histologically, PES resembles...
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Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas
This study aimed to re-evaluate the prognostic impact of TP53 mutations and to identify specific chromosomal aberrations as possible prognostic...
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Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis
BackgroundAtherosclerosis (AS) is a fundamental pathological state in various cardiovascular diseases. Geniposide, which is the main active component...
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Predictive factors of endometriosis progression into ovarian cancer
BackgroundIn recent years, the endometriosis has overcome a noteworthy renaissance in the recognition of its potential. In certain patients, a...
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Case report: pseudoendocrine sarcoma, a clinicopathologic report of a newly described soft tissue neoplasm
Papke et al. recently reported a series of twenty-three soft tissue lesions chiefly arising in older adults featuring distinct morphological and...
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Integrated genomic analyses of hepatocellular carcinoma
BackgroundGenomic alterations play important roles in the development of cancer. We explored the impact of protein-coding genes and transcriptomic...
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Non-hyalinizing trabecular thyroid adenoma: a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma
BackgroundOnly one thyroid follicular cell-derived tumor with a purely trabecular growth pattern has previously been described. This report aims to...
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A systematic review of molecular alterations in invasive non-functioning pituitary adenoma
PurposeInvasive non-functional pituitary adenomas (NFPAs) constitute 35% of NFPAs. Despite a relatively large body of molecular investigations on the...
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Adenoid ameloblastoma harbors beta-catenin mutations
Adenoid ameloblastoma is a very rare benign epithelial odontogenic tumor characterized microscopically by epithelium resembling conventional...
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RA-RAR signaling promotes mouse vaginal opening through increasing β-catenin expression and vaginal epithelial cell apoptosis
BackgroundRetinoic acid (RA) plays important role in the maintenance and differentiation of the Müllerian ducts during the embryonic stage via RA...
