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Statins reduce castration-induced bone marrow adiposity and prostate cancer progression in bone
A fraction of patients undergoing androgen deprivation therapy (ADT) for advanced prostate cancer (PCa) will develop recurrent castrate-resistant PCa...
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MicroRNA expression profiles of the thyroid after goiter formation and involution in rats under different iodine regimens
BackgroundThyroid damage occurs during experimental iodine-deficient goiter and involution with iodine supplementation. This study investigated the...
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Differences in expression and function of LEF1 isoforms in normal versus leukemic hematopoiesis
Acute myeloid leukemia (AML) is the most common acute leukemia in adults and is propagated by leukemic stem cells (LSCs), often characterized by...
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Faithful preclinical mouse models for better translation to bedside in the field of immuno-oncology
The success of immunotherapy using immune checkpoint inhibitors has changed the practice of cancer treatment tremendously. However, there are still...
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Role of the adaptive immune response in sepsis
Sepsis is a syndrome of shock and dysfunction of multiple vital organs that is caused by an uncontrolled immune response to infection and has a high...
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Turning strains into strengths for understanding psychiatric disorders
There is a paucity in the development of new mechanistic insights and therapeutic approaches for treating psychiatric disease. One of the major...
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Bisphosphonates as disease-modifying drugs in osteoarthritis preclinical studies: a systematic review from 2000 to 2020
Bisphosphonates have been proposed as possible disease-modifying drugs in osteoarthritis. However, the evidence of their efficacy is poor and their...
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Adenosine-producing regulatory B cells in head and neck cancer
BackgroundMultiple mechanisms of immunosuppression have been identified in the tumor microenvironment including regulatory B cells (B reg ). Recently,...
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Molecular determinants of disease severity in urinary tract infection
The most common and lethal bacterial pathogens have co-evolved with the host. Pathogens are the aggressors, and the host immune system is responsible...
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Proposed mechanisms of low-level light therapy in the treatment of androgenetic alopecia
Androgenetic alopecia (AGA) is a global challenge, affecting a large number of people worldwide. Efficacy of the existed treatments can barely meet...
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Targeting Histone Modifications in Bone and Lung Metastatic Cancers
Purpose of ReviewBreast cancer frequently metastasizes to the bone and lung, but the ability to treat metastatic tumor cells remains a pressing...
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Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is a multifunctional RNA-binding protein with an oncofetal pattern of expression shown...
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Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function
BackgroundFailure to attain peak lung function by early adulthood is a risk factor for chronic lung diseases. Previously, we reported that C3H/HeJ...
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Intraepithelial neutrophils in mammary, urinary and gall bladder infections
Neutrophil mobilization is a crucial response to protect the host against invading microorganisms. Neutrophil recruitment and removal have to be...
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Immune-relevant aspects of murine models of head and neck cancer
Head and neck cancers (HNCs) cause significant mortality and morbidity. There have been few advances in therapeutic management of HNC in the past 4...
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Assessing the translational value of pre-clinical studies for clinical response rate in oncology: an exploratory investigation of 42 FDA-approved small-molecule targeted anticancer drugs
PurposeTo assess the translational value of anticancer preclinical models, we retrospectively investigated the relationships between preclinical data...
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CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil
BackgroundChagas disease is endemic in Latin America and still represents an important public health problem in the region. Chronic cardiomyopathy is...
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Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review
Adolescence is an important developmental period associated with increased risk for excessive alcohol use, but also high rates of recovery from...
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Irradiation by high-intensity red light-emitting diode enhances human bone marrow mesenchymal stem cells osteogenic differentiation and mineralization through Wnt/β-catenin signaling pathway
Photobiomodulation therapy (PBMT) using a light-emitting diode (LED) has been employed for various photomedicine studies. The aim of this study was...
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The pathogenesis and management of renal scarring in children with vesicoureteric reflux and pyelonephritis
Bacterial urinary tract infections (UTIs) are one of the most common reasons for children to be admitted to hospital. Bacteria infect and invade the...