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Misdiagnosed metabolic bone abnormality: a case report
BackgroundMetabolic bone disease causes significant morbidity and mortality, especially when misdiagnosed. With genetic testing, multiple disease...
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Bone health in children with Angelman syndrome at the ENCORE Expertise Center
Angelman syndrome (AS) is a rare genetic disorder due to lack of UBE3A function on chromosome 15q11.2q13 caused by a deletion, uniparental paternal...
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Interfacial Tissue Regeneration with Bone
Purpose of ReviewInterfacial tissue exists throughout the body at cartilage-to-bone (osteochondral interface) and tendon-to-bone (enthesis)...
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Puberty and Bone Health in Chronic Disease
Linear growth, onset of and progress through puberty are all adversely affected by chronic diseases during childhood and adolescence. Peak bone mass...
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Complications analysis of Ilizarov bone transport technique in the treatment of tibial bone defects–a retrospective study of 199 cases
BackgroundThe clinical treatment of long bone defets in the extremities caused by trauma, infection, tumours, and nonunion has been a challenge for...
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Imprinting disorders
Imprinting disorders (ImpDis) are congenital conditions that are characterized by disturbances of genomic imprinting. The most common individual...
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Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis
Vitamin D is a fat-soluble steroid hormone that was initially known only for regulating calcium and phosphorus levels and maintaining bone health....
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The role of biomineralization in disorders of skeletal development and tooth formation
The major mineralized tissues are bone and teeth, which share several mechanisms governing their development and mineralization. This crossover...
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Mechanisms of preferential bone formation in myeloma bone lesions by proteasome inhibitors
Proteasome inhibitors (PIs) can preferentially restore bone in bone-defective lesions of patients with multiple myeloma (MM) who respond favorably to...
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Effect of standing frames used in real life on bone remodeling in non-walking children with cerebral palsy
SummaryChildren with severe cerebral palsy are prone to low bone mineral density. No clear recommendation exists for an optimal use of standing frame...
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Bone mineral density assessment in patients with cystinuria
BackgroundCystinuria is a rare genetic disease characterized by impaired tubular transport of cystine. Clinical features of cystinuria mainly include...
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Drug Treatment of Low Bone Mass and Other Bone Conditions in Pediatric Patients
Osteoporosis may affect young individuals, albeit infrequently. In childhood, bone mass increases, reaching its peak between the second and third...
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Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling...
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How does Hashimoto’s thyroiditis affect bone metabolism?
Bone marrow contains resident cellular components that are not only involved in bone maintenance but also regulate hematopoiesis and immune...
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Longitudinal changes of the femoral bone mineral density from first to third trimester of pregnancy: bone health assessment by means of non-ionizing REMS technology
BackgroundThroughout the pregnancy, there is a substantial transfer of calcium from the maternal skeleton to the fetus, which leads to a transient...
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Traditional Chinese medicine promotes bone regeneration in bone tissue engineering
Bone tissue engineering (BTE) is a promising method for the repair of difficult-to-heal bone tissue damage by providing three-dimensional structures...
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Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway
BackgroundOsteoporosis is a very common skeletal disorder that increases the risk of fractures. However, the treatment of osteoporosis is...
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The decisive early phase of bone regeneration
Bone has a remarkable endogenous regenerative capacity that enables scarless healing and restoration of its prior mechanical function, even under...
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Novel alendronate-CGS21680 conjugate reduces bone resorption and induces new bone formation in post-menopausal osteoporosis and inflammatory osteolysis mouse models
Loss of bone is a common medical problem and, while it can be treated with available therapies, some of these therapies have critical side effects....
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Effect of early preventive supplementation with calcium and phosphorus on metabolic bone disease in premature infants
ObjectiveThe objective was to study the effect of early preventive calcium and phosphorus supplementation on metabolic bone disease in preterm...
