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Identification of the specific molecular and functional signatures of pre-beta-HDL: relevance to cardiovascular disease
While low concentrations of high-density lipoprotein-cholesterol (HDL-C) are widely accepted as an independent cardiovascular risk factor,...
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Uroplakin 1a Interacts with Regucalcin and Proteasome Subunit Beta 1
Uroplakins (UPKs) are specialized proteins that plan an important role in protecting the epithelium of the bladder from toxic waste. We recently...
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CRISPR-Cas9 system: a novel and promising era of genotherapy for beta-hemoglobinopathies, hematological malignancy, and hemophilia
Gene therapy represents a significant potential to revolutionize the field of hematology with applications in correcting genetic mutations,...
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A new beta cell-specific mitophagy reporter mouse shows that metabolic stress leads to accumulation of dysfunctional mitochondria despite increased mitophagy
Aims/hypothesisMitophagy, the selective autophagy of mitochondria, is essential for maintenance of mitochondrial function. Recent studies suggested...
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RELA governs a network of islet-specific metabolic genes necessary for beta cell function
Aims/hypothesisNF-κB activation unites metabolic and inflammatory responses in many diseases yet less is known about the role that NF-κB plays in...
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Nervous regulation: beta-2-adrenergic signaling in immune homeostasis, cancer immunotherapy, and autoimmune diseases
Beta-2-adrenergic receptor ( β 2 -AR) mediates neural signaling from the sympathetic nervous system (SNS) to the immune system to modulate immunogenic...
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Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression
Tumor-secreted exosomes have a wide range of effects on the growth, metastasis, and drug resistance of cancer cells. However, whether and how the...
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Development of a Biosimilar of Agalsidase Beta for the Treatment of Fabry Disease: Preclinical Evaluation
Background and ObjectiveFabry disease (FD) is a rare lysosomal storage disorder caused by a deficiency of the enzyme α-galactosidase A (aGal A)....
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HbA1c or fructosamine on evaluating glucose intolerance in children with beta- thalassemia
BackgroundBeta-thalassemia major (β-TM) patients are more likely to experience blood glucose intolerance and to date; the blood markers that could...
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Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system
Aims/hypothesisWhile pancreatic beta cells have been shown to originate from endocrine progenitors in ductal regions, it remains unclear precisely...
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Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Older Adults with Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Study
ObjectivesSarcopenia is recognized as a major public health concern because of its association with several adverse health events....
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Comparison effects of Ferula gummosa essential oil and Beta-pinene Alginate nanoparticles on human melanoma and breast cancer cells proliferation and apoptotic index in short term normobaric hyperoxic model
BackgroundBreast cancer is the most common cancer among women, and melanoma is the most dreadful type of skin cancer. Due to the side effects of...
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Use of beta-blockers in patients with ductal carcinoma in situ and risk of invasive breast cancer recurrence: a Swedish retrospective cohort study
BackgroundRetrospective observational studies suggest a potential role of beta-blockers as a protective strategy against progression and metastasis...
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Prolyl 4-hydroxylase subunit beta (P4HB) could serve as a prognostic and radiosensitivity biomarker for prostate cancer patients
BackgroundProlyl 4-hydroxylase subunit beta (P4HB) has been reported as a suppressor in ferroptosis. However, no known empirical research has focused...
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Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters
BackgroundSince the beginning of the COVID-19 pandemic, several variants of concern (VOC) have emerged for which there is evidence of an increase in...
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COVID-19 Vaccine Response in People with Multiple Sclerosis Treated with Dimethyl Fumarate, Diroximel Fumarate, Natalizumab, Ocrelizumab, or Interferon Beta Therapy
BackgroundSome multiple sclerosis (MS) disease-modifying therapies (DMTs) impair responses to vaccines, emphasizing the importance of understanding...
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Role of transforming growth factor beta in assessment of severity of hypersensitivity pneumonitis: a single center study
BackgroundHypersensitivity pneumonitis (HP) is a more frequently diagnosed picture of diffuse parenchymal lung disease. It is an inflammation of the...
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The Potential of Cell Sheet Technology for Beta Cell Replacement Therapy
Purpose of ReviewHere, we review the use of cell sheet technology using different cell types and its potential for restoring the extracellular matrix...
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Prevalence of markers of beta cell autoimmunity and thyroid disease in children with coeliac disease
BackgroundOver the last decades, the prevalence of coeliac disease (CD), an autoimmune disorder, rose to 1–2%. Whether patients with CD have higher...
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Quantifying beta cell function in the preclinical stages of type 1 diabetes
Clinically symptomatic type 1 diabetes (stage 3 type 1 diabetes) is preceded by a pre-symptomatic phase, characterised by progressive loss of...
