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Targeted proteomics identifies potential biomarkers of dysglycaemia, beta cell function and insulin sensitivity in Black African men and women
Aims/hypothesisUsing a targeted proteomics approach, we aimed to identify and validate circulating proteins associated with impaired glucose...
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USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells
ObjectiveObesity-induced kidney injury contributes to the development of diabetic nephropathy (DN). Here, we identified the functions of...
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Improved Insulin Secretion Response and Beta-cell Function Correlated with Increased Prolactin Levels After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients with Acanthosis Nigricans
ObjectiveTo explore insulin secretion patterns, β-cell function, and serum prolactin (PRL) concentrations in Chinese morbidly obese patients with...
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Improvement of beta-cell function in conjunction with glycemic control after medical nutrition therapy in newly-diagnosed type 2 diabetes mellitus
BackgroundThe current study aimed to reveal the correlation of beta-cell function and insulin sensitivity with glycemic control and weight control...
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Obstructive sleep apnea (OSA) is associated with the impairment of beta-cell response to glucose in children and adolescents with obesity
BackgroundThe main purpose of the study is to assess the association between obstructive sleep apnea (OSA) and insulin secretion in children with...
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Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia
Male factor infertility affects 50% of infertile couples worldwide; the most severe form, non-obstructive azoospermia (NOA), affects 10–15% of...
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Didymin protects pancreatic beta cells by enhancing mitochondrial function in high-fat diet-induced impaired glucose tolerance
PurposeProlonged exposure to plasma free fatty acids (FFAs) leads to impaired glucose tolerance (IGT) which can progress to type 2 diabetes (T2D) in...
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Age-related adiposity and beta-cell function: impact on prediabetes and diabetes prevalence in middle-aged and older Han Chinese adults
PurposeTo investigate the effect of aging on the prevalence of prediabetes and diabetes, and the influence of aging on the associations among adipose...
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Increased hexosamine biosynthetic pathway flux alters cell–cell adhesion in INS-1E cells and murine islets
PurposeIn type 2 Diabetes, β-cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction (dedifferentiation,...
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Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology
AbstractThe highest incidence of sepsis across all age groups occurs in neonates leading to substantial mortality and morbidity. Cardiovascular...
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Coronary Microvascular Dysfunction in Women
Purpose of ReviewPatients who are suspected of having symptoms from myocardial ischemia routinely undergo coronary angiography to evaluate for...
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Thyroid disorders and male sexual dysfunction
Though early research suggested that thyroid hormones were not involved with the testes, male spermatogenesis, or erectile function, investigations...
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Immunotherapy-induced thyroid dysfunction: an updated review
Immunotherapy medicines (immune checkpoint inhibitors, ICIs) that work directly on the immune system have shown vastly increased survival for people...
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Association between triglyceride-glucose index and endothelial dysfunction
BackgroundTriglyceride-glucose (TyG) index, a simple surrogate marker for insulin resistance (IR), has been reported as an independent predictor of...
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Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood
ObjectivesFamine exposure in early life was associated with type 2 diabetes, non-alcoholic fatty liver disease and metabolic syndrome, etc. But...
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Hyperphosphatemia and its relationship with blood pressure, vasoconstriction, and endothelial cell dysfunction in hypertensive hemodialysis patients
BackgroundHyperphosphatemia occurs frequently in end-stage renal disease patients on hemodialysis and is associated with increased mortality....
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CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity
BackgroundThe primary underlying defect in cystic fibrosis (CF) is disrupted ion transport in epithelia throughout the body. It is unclear if...
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Erectile function and androgen and estrogen beta receptor gene polymorphisms in acromegalic men
PurposeSexual dysfunctions are often experienced by male patients with acromegaly, due to a combination of hypogonadism and other comorbidities, but...
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Association of serum osteocalcin with beta cell function, insulin resistance, and glycemic parameters in south Indian type 2 diabetic subjects
BackgroundOsteocalcin (OC), also known as bone Gla (gamma-carboxyglutamic acid) protein, is a marker of bone formation. OC has effect on glucose and...
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SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells
Aims/hypothesisIncreased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in type 1 and type 2...
