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Multi-biological activity assessment and phytochemical characterization of an aqueous extract of the Cymbopogon citratus grown in Palestine
BackgroundPlants have historically been a rich source of medicinal compounds, with many modern pharmaceuticals derived from botanical origins. In...
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Chemical composition, cholinesterase, and α-glucosidase inhibitory activity of the essential oils of some Iranian native Salvia species
BackgroundThe plants from Salvia genus contain widely distributed species which have been used in folk medicine as well as pharmaceutical and food...
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Lifestyle management in polycystic ovary syndrome – beyond diet and physical activity
Polycystic ovary syndrome (PCOS) is a common condition affecting reproductive-aged women with reproductive, metabolic and psychological consequences....
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Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?
Efficient treatment of stress-related disorders, such as depression, is still a major challenge. The onset of antidepressant drug action is generally...
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Blocking CCR5 activity by maraviroc augmentation in post-stroke depression: a proof-of-concept clinical trial
BackgroundPost-stroke depression (PSD) is a significant impediment to successful rehabilitation and recovery after a stroke. Current therapeutic...
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Reduced prefrontal cortex and sympathetic nervous system activity correlate with fatigue after aHSCT
Long-term fatigue and cognitive dysfunction affects 35% of allogeneic haematopoietic stem cell transplantation (aHSCT) survivors, suggesting a...
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Medicinal Cannabis for the Treatment of Anxiety Disorders: a Narrative Review
Purpose of reviewAnxiety is a prevalent mental health condition which manifests as a disproportionate response of fear to a perceived threat....
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Effects of single- and multiple-dose oxytocin treatment on amygdala low-frequency BOLD fluctuations and BOLD spectral dynamics in autism
Prior neuroimaging clinical trials investigating the neural effects of intranasal administration of the neuropeptide oxytocin demonstrated a key role...
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Psychological symptoms and brain activity alterations in women with PCOS and their relation to the reduced quality of life: a narrative review
BackgroundPolycystic ovary syndrome (PCOS) is the most common feminine endocrine disorder, characterized by androgen excess, ovulatory dysfunction,...
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D1 receptor-expressing neurons in ventral tegmental area alleviate mouse anxiety-like behaviors via glutamatergic projection to lateral septum
Dopamine (DA) acts as a key regulator in controlling emotion, and dysfunction of DA signal has been implicated in the pathophysiology of some...
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Qualitative assessment of the flowering buds of Mesua ferrea Linn with special emphasize on HPTLC and universal DNA bar-coding technique and evaluation of its antimicrobial potential
BackgroundThe study has been scientifically exploring the powder sample and extracts of flowering buds of Mesua ferrea Linn (FBMF) based on...
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Anxiety in oncology outpatients is associated with perturbations in pathways identified in anxiety focused network pharmacology research
PurposeEvaluate for perturbed signaling pathways associated with subgroups of patients with low versus high levels of state anxiety. These pathways...
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Benzodiazepines Reduce Blood Pressure in Short Term: A Systematic Review and Meta-analysis
Purpose of ReviewBenzodiazepines, due to their anxiolytic properties, are prescribed to reduce anxiety and insomnia. They might have hypotensive...
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Symptomatic and neurotrophic effects of GABAA receptor positive allosteric modulation in a mouse model of chronic stress
Chronic stress is a risk factor for Major Depressive Disorder (MDD), and in rodents, it recapitulates human behavioral, cellular and molecular...
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Videoconference-Supervised Group Exercise Reduces Low Back Pain in Eldercare Workers: Results from the ReViEEW Randomised Controlled Trial
PurposeTo assess the effects of a group exercise intervention conducted by real-time videoconference on the low back pain of eldercare workers.
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Evaluation of neurobehavioral activities of ethanolic extract of Psidium guajava Linn leaves in mice model
BackgroundThe complementary and alternative medicines have particular importance in treating various comorbid conditions including anxiety and...
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TAAR1 regulates drug-induced reinstatement of cocaine-seeking via negatively modulating CaMKIIα activity in the NAc
Relapse remains a major challenge to the treatment of cocaine addiction. Recent studies suggested that the trace amine-associated receptor 1 (TAAR1)...
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Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression
BackgroundDepression is a severe neuropsychiatric disorder that affects more than 264 million people worldwide. The efficacy of conventional...
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Unraveling the epigenomic and transcriptomic interplay during alcohol-induced anxiolysis
Positive effects of alcohol drinking such as anxiolysis and euphoria appear to be a crucial factor in the initiation and maintenance of alcohol use...
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Potential Role of Curcumin for the Treatment of Major Depressive Disorder
Curcumin is the major biologically active polyphenolic constituent in the turmeric plant ( Curcuma longa ) that has been shown to have antioxidant,...
