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The correlation between the lumbar disc MRI high-intensity zone and discogenic low back pain: a systematic review and meta-analysis
ObjectiveThis study aimed to investigate the correlation between the MRI high-intensity zone (HIZ) and the pathogenesis of discogenic low back pain.
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Role of Galectin-3 in intervertebral disc degeneration: an experimental study
BackgroundThis study investigated the role of Galectin-3 in the degeneration of intervertebral disc cartilage.
MethodsThe patients who underwent...
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Manipulation of osteogenic and adipogenic differentiation of human degenerative disc and ligamentum flavum derived progenitor cells using IL-1β, IL-19, and IL-20
PurposeTo elucidate whether pro-inflammatory cytokines might influence the commitment of intervertebral disc (IVD)- and ligamentum flavum...
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Therapeutic effect and mechanism of Yougui Wan in rats with intervertebral disk degeneration
ObjectiveTo explore the potential mechanism of Yougui Wan on deformed lumbar intervertebral disk structure in rats.
MethodsThirty male...
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Single-cell RNA sequencing in orthopedic research
Although previous RNA sequencing methods have been widely used in orthopedic research and have provided ideas for therapeutic strategies, the...
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Cell-based strategies for IVD repair: clinical progress and translational obstacles
Intervertebral disc (IVD) degeneration is a major cause of low back pain, a prevalent and chronic condition that has a striking effect on quality of...
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A novel artificial vertebral implant with Gyroid porous structures for reducing the subsidence and mechanical failure rate after vertebral body replacement
BackgroundProsthesis subsidence and mechanical failure were considered significant threats after vertebral body replacement during the long-term...
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Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration
ObjectiveIntervertebral disc degeneration (IVDD) is a major cause of morbidity and disability. Our study aimed to investigate the potential of...
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Hypoxia regulates adipose mesenchymal stem cells proliferation, migration, and nucleus pulposus-like differentiation by regulating endoplasmic reticulum stress via the HIF-1α pathway
ObjectiveHypoxia can promote stem cell proliferation and migration through HIF-1α. Hypoxia can regulate cellular endoplasmic reticulum (ER) stress....
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Biomechanical effects of transverse connectors on total en bloc spondylectomy of the lumbar spine: a finite element analysis
BackgroundThe influence of total en bloc spondylectomy (TES) on spinal stability is substantial, necessitating strong fixation to restore spinal...
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Ultra-short echo time MR imaging in assessing cartilage endplate damage and relationship between its lesion and disc degeneration for chronic low back pain patients
ObjectiveTo investigate the feasibility of ultra-short echo time (UTE) magnetic resonance imaging (MRI) in the assessment of cartilage endplate (CEP)...
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Mechanism of YAP1 in the senescence and degeneration of endplate chondrocytes induced by intermittent cyclic mechanical tension
BackgroundThis study aimed to investigate the potential mechanism of YAP1 in the senescence and degeneration of endplate chondrocytes induced by...
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Standardisation of basal medium for reproducible culture of human annulus fibrosus and nucleus pulposus cells
BackgroundThe lifetime prevalence of degenerative disc disease is dramatically high. Numerous investigations on disc degeneration have been performed...
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Oral dextran sulfate sodium administration induces peripheral spondyloarthritis features in SKG mice accompanied by intestinal bacterial translocation and systemic Th1 and Th17 cell activation
BackgroundSpondyloarthritis (SpA) is an autoimmune and autoinflammatory musculoskeletal disease characterised by systemic enthesitis. Recent research...
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TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo
BackgroundIntervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular...
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A new perspective on intervertebral disc calcification—from bench to bedside
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to understand the spectrum of disc...
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Does vertebral osteoporosis delay or accelerate lumbar disc degeneration? A systematic review
The effect of vertebral osteoporosis on disc degeneration is still debated. The purpose of this study was to provide a systematic review of studies...
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Lateral fenestration of lumbar intervertebral discs in rabbits: development and characterisation of an in vivo preclinical model with multi-modal endpoint analysis
PurposeTo evaluate the biological and biomechanical effects of fenestration/microdiscectomy in an in vivo rabbit model, and in doing so, create a...
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Are serum thyroid hormone, parathormone, calcium, and vitamin D levels associated with lumbar spine degeneration? A cross-sectional observational clinical study
PurposeLow back pain (LBP) impairs the quality of life and rises healthcare costs. The association of spine degeneration and LBP with metabolic...
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Psoralen synergizes with exosome-loaded SPC25 to alleviate senescence of nucleus pulposus cells in intervertebral disc degeneration
ObjectiveTo explore the mechanism of psoralen synergized with exosomes (exos)-loaded SPC25 on nucleus pulposus (NP) cell senescence in intervertebral...
