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Blood levels of glial fibrillary acidic protein for predicting clinical progression to Alzheimer’s disease in adults without dementia: a systematic review and meta-analysis protocol
BackgroundThere is urgent clinical need to identify reliable prognostic biomarkers that predict the progression of dementia symptoms in individuals...
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Pooled analysis of patients with inherited prion disease caused by two- to twelve-octapeptide repeat insertions in the prion protein gene (PRNP)
Inherited prion diseases caused by two- to twelve-octapeptide repeat insertions (OPRIs) in the prion protein gene ( PRNP ) show significant clinical...
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Reactivity to neural tissue epitopes, aquaporin 4 and heat shock protein 60 is associated with activated immune–inflammatory pathways and the onset of delirium following hip fracture surgery
ObjectivesActivation of the immune–inflammatory response system (IRS) and a deficiency in the compensatory immunoregulatory system (CIRS), neuronal...
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Protein Expression of immune checkpoints STING and MHCII in small cell lung cancer
BackgroundSCLC is an aggressive malignancy where immunotherapies show limited efficacy. We aimed to characterize the SCLC microenvironment according...
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Discrimination is associated with C-reactive protein among young sexual minority men
This report examines associations between everyday discrimination, microaggressions, and CRP to gain insight on potential mechanisms that may...
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Biological functions and potential therapeutic applications of huntingtin-associated protein 1: progress and prospects
Huntington disease (HD) is a single-gene autosomal dominant inherited neurodegenerative disease caused by a polyglutamine expansion of the protein...
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Evaluating the Effects of Increased Protein Intake on Muscle Strength, Hypertrophy and Power Adaptations with Concurrent Training: A Narrative Review
Concurrent training incorporates dual exercise modalities, typically resistance and aerobic-based exercise, either in a single session or as part of...
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Increased activation product of complement 4 protein in plasma of individuals with schizophrenia
Structural variation in the complement 4 gene ( C4 ) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy...
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Big knowledge visualization of the COVID-19 CIDO ontology evolution
BackgroundThe extensive international research for medications and vaccines for the devastating COVID-19 pandemic requires a standard reference...
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Immunotherapies Targeting Amyloid and Tau Protein in Alzheimer’s Disease: Should We Move Away from Diseases and Focus on Biological Targets? A Systematic Review and Expert Opinion
IntroductionAlzheimer’s disease (AD) is the most common cause of dementia worldwide, making it a major public health issue. Anti-amyloid and anti-tau...
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Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a progressive fatal neurodegenerative disease caused by loss of motor neurons and characterized neuropathologically...
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Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials
Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed that aberrant PPIs are associated with various diseases,...
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Rare coding variants as risk modifiers of the 22q11.2 deletion implicate postnatal cortical development in syndromic schizophrenia
22q11.2 deletion is one of the strongest known genetic risk factors for schizophrenia. Recent whole-genome sequencing of schizophrenia cases and...
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Calcium oxalate crystals trigger epithelial-mesenchymal transition and carcinogenic features in renal cells: a crossroad between kidney stone disease and renal cancer
Increasing evidence of association between kidney stone disease (KSD) and renal cell carcinoma (RCC) has been reported. Nevertheless, mechanism...
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Frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43): its journey of more than 100 years
Frontotemporal lobar degeneration (FTLD) with TDP-43-immunoreactive inclusions (FTLD–TDP) is a neurodegenerative disease associated with clinical,...
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Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling
PurposeIschemic postconditioning (IPostC) alleviates myocardial ischemia/reperfusion (IR) injury, but the protective effect is lost during diabetes....
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Protein kinase CK2: a potential therapeutic target for diverse human diseases
CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is...
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One Health—One Biofilm
Bacterial biofilms are structured clusters of bacterial cells enclosed in a self-produced polymer matrix that are attached to a biotic or abiotic...
