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Gastric intestinal metaplasia: progress and remaining challenges
Most gastric cancers arise in the setting of chronic inflammation which alters gland organization, such that acid-pum** parietal cells are lost,...
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Chemoprevention of pancreatic cancer by inhibition of glutathione-S transferase P1
Pancreatic cancer is among the most refractory malignancies with poor prognosis. Thus, preventive approaches, in addition to the development of novel...
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Krill oil supplementation reduces the growth of CT-26 orthotopic tumours in Balb/c mice
BackgroundWe have previously reported that the free fatty acid extract (FFAE) of krill oil (KO) significantly inhibits the proliferation and...
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Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
Evidence from physical sciences in oncology increasingly suggests that the interplay between the biophysical tumor microenvironment and genetic...
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Spot-light on microbiota in obesity and cancer
Over the last few years, the complexity and diversity of gut microbiota within and across individuals has been detailed in relation to human health....
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Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2020 for the Clinical Practice of Hereditary Colorectal Cancer
Hereditary colorectal cancer (HCRC) accounts for < 5% of all colorectal cancer cases. Some of the unique characteristics commonly encountered in HCRC...
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Colorectal liver metastasis: molecular mechanism and interventional therapy
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver...
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Nerves in gastrointestinal cancer: from mechanism to modulations
Maintenance of gastrointestinal health is challenging as it requires balancing multifaceted processes within the highly complex and dynamic ecosystem...
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CACA guidelines for holistic integrative management of rectal cancer
PurposeColorectal cancer is a common malignant tumor worldwide. In China, the ratio of rectal cancer to colon cancer in terms of incidence is close...
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Preclinical Evidence of Probiotics in Colorectal Carcinogenesis: A Systematic Review
BackgroundColorectal cancer, the second major cause of cancer deaths, imposes a major health burden worldwide. There is growing evidence that...
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An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas
Our understanding of serrated colorectal polyps has increased dramatically over the past two decades and has led to a modern classification scheme...
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Metformin and colorectal cancer: a systematic review, meta-analysis and meta-regression
PurposeMetformin may have a role in reducing the incidence of colorectal cancer (CRC) and improving survival outcome. This meta-analysis explored the...
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CRL4ADTL degrades DNA-PKcs to modulate NHEJ repair and induce genomic instability and subsequent malignant transformation
Genomic instability induced by DNA damage and improper DNA damage repair is one of the main causes of malignant transformation and tumorigenesis. DNA...
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Proliferative Verrucous Leukoplakia: An Expert Consensus Guideline for Standardized Assessment and Reporting
AbstractThe many diverse terms used to describe the wide spectrum of changes seen in proliferative verrucous leukoplakia (PVL) have resulted in...
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Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition
Inflammation is an established risk factor for colorectal cancer. We and others have shown that colorectal cancer patients with elevated cysteinyl...
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MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity
Many adenocarcinomas, including colorectal cancer (CRC), overexpress the MUC13 cell surface mucin, but the functional significance and mechanisms are...
