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De novo variants in immune regulatory genes in Down syndrome regression disorder
BackgroundDown Syndrome Regression Disorder (DSRD) is a rare and poorly understood disorder of the central nervous system, characterized by acute or...
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Transcriptome-wide association study identifies new susceptibility genes and pathways for spondyloarthritis
BackgroundSpondyloarthritis (SpA) is a group of multifactorial bone diseases influenced by genetic factors, the environment and lifestyle. However,...
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Analysis of prognostic value of lactate metabolism-related genes in ovarian cancer based on bioinformatics
BackgroundRecent studies have provided evidence supporting the functional role and mechanism of lactate in suppressing anticancer immunity. However,...
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Screening and Analysis of Core Genes for Osteoporosis Based on Bioinformatics Analysis and Machine Learning Algorithms
ObjectiveThis study aimed to identify osteoporosis-related core genes using bioinformatics analysis and machine learning algorithms.
Methods ...
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A prognostic model of idiopathic pulmonary fibrosis constructed based on macrophage and mitochondria-related genes
BackgroundStudies have shown that mitochondrial function and macrophages may play a role in the development of idiopathic pulmonary fibrosis (IPF)....
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Identification of common core ion channel genes in epilepsy and Alzheimer’s disease
BackgroundAlthough available literature indicates that the incidence of dementia in the epilepsy population and the risk of seizures in the...
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Analysis of m6A-regulated genes and subtype classification in lupus nephritis
BackgroundLupus nephritis (LN) is the most common and severe clinical manifestation of systemic lupus erythematosus (SLE). N6-methyladenosine (m6A)...
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Identification of differentially expressed ER stress-related genes and their association with pulmonary arterial hypertension
BackgroundPulmonary arterial hypertension (PAH) is a complex and progressive illness that has a multifaceted origin, significant fatality rates, and...
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Relationship between circadian rhythm-related genes and extracellular matrix: implications for sleep deprivation
BackgroundSleep deprivation (SD) can lead to the development of various pathological disorders. The extracellular matrix (ECM) compositions and...
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Dysregulated cholesterol regulatory genes in hepatocellular carcinoma
Cholesterol is an indispensable component in mammalian cells, and cholesterol metabolism performs important roles in various biological activities....
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Identifying therapeutic target genes for migraine by systematic druggable genome-wide Mendelian randomization
BackgroundCurrently, the treatment and prevention of migraine remain highly challenging. Mendelian randomization (MR) has been widely used to explore...
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Novel ratio-expressions of genes enables estimation of wound age in contused skeletal muscle
Given that combination with multiple biomarkers may well raise the predictive value of wound age, it appears critically essential to identify new...
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Unravelling driver genes as potential therapeutic targets in ovarian cancer via integrated bioinformatics approach
Target-driven cancer therapy is a notable advancement in precision oncology that has been accompanied by substantial medical accomplishments. Ovarian...
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Identification of crucial genes related to heart failure based on GEO database
BackgroundThe molecular biological mechanisms underlying heart failure (HF) remain poorly understood. Therefore, it is imperative to use innovative...
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Prioritization of genes associated with type 2 diabetes mellitus for functional studies
Existing therapies for type 2 diabetes mellitus (T2DM) show limited efficacy or have adverse effects. Numerous genetic variants associated with T2DM...
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Ferroptosis-related genes LPCAT3 and PGD are potential diagnostic biomarkers for osteoarthritis
BackgroundOsteoarthritis (OA) is the most common chronic joint disease and how ferroptosis contributes to OA has garnered much attention recently....
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Prognosis and immunotherapy response prediction based on M2 macrophage-related genes in colon cancer
BackgroundM2 macrophage were revealed to play a crucial role in immune evasion and immunotherapies. This study aims to explore the potential...
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Identifying key genes for diabetic kidney disease by bioinformatics analysis
BackgroundThere are no reliable molecular targets for early diagnosis and effective treatment in the clinical management of diabetic kidney disease...
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Comprehensive analysis and prognostic assessment of senescence-associated genes in bladder cancer
BackgroundThe prevalence and mortality of bladder cancer (BLCA) present a significant medical challenge. While the function of senescence-related...
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Comprehensive DNA methylation profiling by MeDIP-NGS identifies potential genes and pathways for epithelial ovarian cancer
Ovarian cancer, among all gynecologic malignancies, exhibits the highest incidence and mortality rate, primarily because it is often presents with...
