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Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men
SummaryWe investigated 383 bone candidate genes for associations between single nucleotide polymorphisms and vertebral trabecular volumetric bone...
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Short term hypothyroidism affects ovarian function in the cycling rat
BackgroundRats made hypothyroid with propilthyouracil start showing abnormal cycling on the second cycle after the start of the treatment, with a...
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Pharmacogenetics of Aromatase Inhibitors: Present Understanding and Looking to the Future
Clinicopathologic characteristics have traditionally played a predominant role in adjuvant therapy recommendations for women with breast cancer. Host...
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A novel promoter controls Cyp19a1 gene expression in mouse adipose tissue
BackgroundAromatase, the key enzyme in estrogen biosynthesis, is encoded by the Cyp19a1 gene. Thus far, 3 unique untranslated first exons associated...
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Genetics of Menstrual Migraine: The Molecular Evidence
Migraine is considered to be a multifactorial disorder in which genetic, environmental, and, in the case of menstrual and menstrually related...
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Direct rosiglitazone action on steroidogenesis and proinflammatory factor production in human granulosa-lutein cells
BackgroundOvarian granulosa cells are the predominant source of estradiol and progesterone biosynthesis in vivo. Rosiglitazone, a synthetic agonist...
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Diverse and Active Roles for Adipocytes During Mammary Gland Growth and Function
The mammary gland is unique in its requirement to develop in close association with a depot of adipose tissue that is commonly referred to as the...
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A combined analysis of genome-wide association studies in breast cancer
In an attempt to identify common disease susceptibility alleles for breast cancer, we performed a combined analysis of three genome-wide association...
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Aromatase deficiency in men: a clinical perspective
Human aromatase deficiency is a very rare syndrome characterized by congenital estrogen deprivation that is caused by loss-of-function mutations in CYP19A1...
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Association of creatin kinase B and peroxiredoxin 2 expression with age and embryo quality in cumulus cells
PurposeThe purpose of this study was to identify age-related oocyte or embryo markers suitable for non-invasive analysis, as women over 38 years of...
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Epidemiologie des Endometriumkarzinoms
An increased risk of endometrial cancer type I is associated with factors which directly or indirectly increase the exposition of the endometrium to...
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Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
Steroid hormones regulate diverse physiological functions such as reproduction, blood salt balance, maintenance of secondary sexual characteristics,...
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Genetic epidemiology of age-related osteoporosis and its clinical applications
Osteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its...
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VEGF-A and Serum Withdrawal Induced Changes in the Transcript Profile in Human Endometrial Endothelial Cells
The changes in transcript profile induced by vascular endothelial growth factor (VEGF-A) and serum withdrawal in primary human endometrial...
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Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase
AMP-activated protein kinase (AMPK) is recognized as a master regulator of energy homeostasis. In concert with the AMPK-kinase LKB1, it has been...
