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Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation
BackgroundGonadal differentiation in the mammalian fetus involves a complex dose-dependent genetic network. Initiation and progression of fetal...
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Genetic variation in the androgen estrogen conversion pathway in relation to breast cancer prognosticators
Genetic variation in the androgen-to-estrogen conversion pathway has been shown to be associated with risk of breast cancer and, in particular, with...
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Potential utility of natural products as regulators of breast cancer-associated aromatase promoters
Aromatase, the key enzyme in estrogen biosynthesis, converts androstenedione to estrone and testosterone to estradiol. The enzyme is expressed in...
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Genetic aspects of premature ovarian failure: a literature review
BackgroundThe diagnosis of premature ovarian failure (POF) is based on the finding of amenorrhea before the age of 40 years associated with...
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Aromatase inhibitors in men: effects and therapeutic options
Aromatase inhibitors effectively delay epiphysial maturation in boys and improve testosterone levels in adult men Therefore, aromatase inhibitors may...
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Genome-wide association reveals genetic effects on human Aβ 42 and τ protein levels in cerebrospinal fluids: a case control study
BackgroundAlzheimer's disease (AD) is common and highly heritable with many genes and gene variants associated with AD in one or more studies,...
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Adherence to oral endocrine treatments in women with breast cancer: can it be improved?
There is a perception that women on oral endocrine treatments for oestrogen receptor-positive breast cancer will be adherent to these medicines, as...
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Between Candidate Genes and Whole Genomes: Time for Alternative Approaches in Blood Pressure Genetics
Blood pressure has a significant genetic component, but less than 3% of the observed variance has been attributed to genetic variants identified to...
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Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology
BackgroundThe prostaglandin D2 (PGD2) pathway is involved in numerous biological processes and while it has been identified as a partner of the...
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Relative expression of genes encoding SMAD signal transduction factors in human granulosa cells is correlated with oocyte quality
PurposeTo determine the expression of SMAD transcripts in human granulosa cells.
MethodsLuteinized mural granulosa cells were harvested from forty...
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Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression
Women are twice as likely as men to develop major depressive disorder (MDD) and are more prone to recurring episodes. Hence, we tested the hypothesis...
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Molecular characterization of the human ovulatory cascade—Lesson from the IVF/IVM model
AimsOvarian follicular development and ovulation in mammals is a complex and highly regulated process. Most advances in the understanding of the...
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Association of polymorphisms in CYP19A1 and CYP3A4 genes with lower urinary tract symptoms, prostate volume, uroflow and PSA in a population-based sample
PurposeThe known importance of testosterone for the development of benign prostatic hyperplasia (BPH) prompted us to test the hypothesis whether...
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Non-small cell lung cancer in never smokers as a representative ‘non-smoking-associated lung cancer’: epidemiology and clinical features
Recent interest in lung cancer without a history of tobacco smoking has led to the classification of a distinct disease entity of...
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Genetische Ursachen der prämaturen Ovarialinsuffizienz und Ovardysgenesie
Premature ovarian insufficiency (POI) is characterized by the onset of amenorrhea before 40 years of age combined with hypergonadotropic...
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The changing therapeutic landscape of castration-resistant prostate cancer
Castration-resistant prostate cancer (CRPC) has a poor prognosis and remains a significant therapeutic challenge. Before 2010, only docetaxel-based...
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Effects of polymorphisms in gonadotropin and gonadotropin receptor genes on reproductive function
Gonadotropins, the action of which is mediated at the level of their gonadal receptors, play a key role in sexual development, reproductive functions...
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Estrogen and androgen signaling in the pathogenesis of BPH
Estrogens and androgens have both been implicated as causes of benign prostatic hyperplasia (BPH). Although epidemiological data on an association...
