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Recent advances in the molecular targeted drugs for prostate cancer
ContextProstate cancer (PCa) is the second largest male tumor in the world and one of the most common malignant tumors in the urinary system. In...
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Long-Term Efficacy and Tolerability of PCSK9 Targeted Therapy: A Review of the Literature
Increased plasma levels of low-density lipoprotein cholesterol (LDL-C) are causally associated with atherosclerotic cardiovascular disease (ASCVD),...
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Targeted therapy in BRAF mutated aggressive papillary craniopharyngioma: a case report and overview of the literature
BackgroundPapillary craniopharyngiomas harbor the BRAF V600E mutation, which paves the way for using BRAF inhibitor molecules to treat tumors...
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RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly...
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Integrated Molecular and Histological Insights for Targeted Therapies in Mesenchymal Sinonasal Tract Tumors
Purpose of ReviewThis review aims to provide a comprehensive overview of mesenchymal sinonasal tract tumors (STTs), a distinct subset of STTs....
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Combination of radiotherapy and targeted therapy for HER2-positive breast cancer brain metastases
Radiotherapy and targeted therapy are essential treatments for patients with brain metastases from human epidermal growth factor receptor 2...
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Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies
Despite the success of targeted therapies in cancer treatment, therapy-induced resistance remains a major obstacle to a complete cure. Tumor cells...
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Biopsy of diffuse midline glioma is safe and impacts targeted therapy: a systematic review and meta-analysis
PurposeTo quantify the safety and utility of biopsy of pediatric diffuse midline glioma (DMG).
MethodsThis study was conducted in accordance with...
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Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is the sixth most frequent cancer, with tobacco, alcohol and...
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Ferroptosis as a promising targeted therapy for triple negative breast cancer
PurposeTriple negative breast cancer (TNBC) is a challenging subtype characterized by the absence of estrogen receptor (ER), progesterone receptor...
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Novel biomolecules in targeted cancer therapy: a new approach towards precision medicine
Cancer is a major threat to human life around the globe, and the discovery of novel biomolecules continue to be an urgent therapeutic need that is...
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Engineered exosomes from different sources for cancer-targeted therapy
Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes...
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Determinants of targeted cancer therapy use in community oncology practice: a qualitative study using the Theoretical Domains Framework and Rummler-Brache process map**
BackgroundPrecision medicine holds enormous potential to improve outcomes for cancer patients, offering improved rates of cancer control and quality...
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Post-transplant maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation harmonizing multiple therapeutic modalities including targeted therapy, immunotherapy and cellular therapy
Allogeneic hematopoietic stem cell transplant (HCT) has improved survival for patients with acute myeloid leukemia (AML), especially for those at...
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Targeted Therapy for MPNs: Going Beyond JAK Inhibitors
Purpose of ReviewJAK inhibition is an effective means of controlling symptom burden and improving splenomegaly in patients with myeloproliferative...
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Panniculitis does not predict clinical response in patients with advanced melanoma under targeted therapy
BackgroundBRAF and MEK inhibitors have changed the landscape of treatment for advanced melanoma. Among their side effects, panniculitis has been...
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Molecular matched targeted therapies for primary brain tumors—a single center retrospective analysis
PurposeMolecular diagnostics including next generation gene sequencing are increasingly used to determine options for individualized therapies in...
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Regulation of VEGF-A expression and VEGF-A-targeted therapy in malignant tumors
Vascular endothelial growth factor A (VEGF-A), a highly conserved dimeric glycoprotein, is a key regulatory gene and a marker molecule of...
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Targeted Alpha Therapy for Glioblastoma: Review on In Vitro, In Vivo and Clinical Trials
Glioblastoma (GB), a prevalent and highly malignant primary brain tumour with a very high mortality rate due to its resistance to conventional...
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Fungal Infections Associated with CD19-Targeted Chimeric Antigen Receptor T Cell Therapy
Purpose of ReviewThis review focuses on the epidemiology of fungal infections after CD19-targeted chimeric antigen receptor (CAR) T cell therapy and...
