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Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice
BackgroundKirsten rat sarcoma (KRAS) and mutant KRAS G12D have been implicated in human cancers, but it remains unclear whether their activation...
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Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B
The subcortical maternal complex (SCMC) is a multiprotein complex in oocytes and preimplantation embryos that is encoded by maternal effect genes....
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Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission route
COVID-19 is identified as a zoonotic disease caused by SARS-CoV-2, which also can cross-transmit to many animals but not mice. Genetic modifications...
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High levels of TIMP1 are associated with increased extracellular matrix stiffness in isocitrate dehydrogenase 1-wild type gliomas
Glioma progression is accompanied with increased tumor tissue stiffness, yet the underlying mechanisms are unclear. Herein, we employed atomic force...
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Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs
IntroductionThe discrepancy between bone mineral density (BMD), the gold standard for bone assessment, and bone strength is a constraint in...
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Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage
BRCA1 mutation is the genetic predisposition in causing genome instability towards cancer. BRCA1 mutation is predominantly germline inherited at the...
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ABE8e Corrects Pax6-Aniridic Variant in Humanized Mouse ESCs and via LNPs in Ex Vivo Cortical Neurons
IntroductionAniridia is a rare congenital vision-loss disease caused by heterozygous variants in the PAX6 gene. There is no vision-saving therapy,...
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Activated FGFR3 suppresses bone regeneration and bone mineralization in an ovariectomized mouse model
BackgroundPostmenopausal osteoporosis is a widespread health concern due to its prevalence among older adults and an associated high risk of...
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A mouse model of type B cystinuria due to spontaneous mutation in FVB/NJcl mice
Cystinuria is an autosomal metabolic disorder caused by mutations in the SLC3A1 and SLC7A9 genes, encoding the amino acid transporter proteins rBAT...
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Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain
CDKL5 is a brain-enriched serine/threonine kinase, associated with a profound developmental and epileptic encephalopathy called CDKL5 deficiency...
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The prognostic role of HIF-1α and NF-κB expression in RAS wild-type metastatic colorectal cancer: A Turkish Oncology Group (TOG) study
BackgroundNot all RAS wild-type metastatic colorectal cancer (mCRC) patients experience the same benefit from anti-epidermal growth factor receptor...
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Anticancer efficacy of hirsuteine against colorectal cancer by opposite modulation of wild-type and mutant p53
PurposeThe present study aimed to explore the anticancer activity of hirsuteine (HST), an indole alkaloid from the traditional Chinese herbal...
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Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients
Primary ciliary dyskinesia (PCD) is a highly heterogeneous recessive inherited disorder. FAP54 , the homolog of CFAP54 in Chlamydomonas reinhardtii ,...
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Establishment of a mouse model of Netherton syndrome based on CRISPR/Cas9 technology
BackgroundNetherton syndrome is a rare but severe autosomal recessive disorder with dominant impaired skin barrier function, caused by mutations in...
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Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients
Schizophrenia is a heterogeneous psychiatric disorder with a strong genetic basis, whose etiology and pathophysiology remain poorly understood. Exome...
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Mitochondrial hypermetabolism precedes impaired autophagy and synaptic disorganization in App knock-in Alzheimer mouse models
Accumulation of amyloid β-peptide (Aβ) is a driver of Alzheimer’s disease (AD). Amyloid precursor protein ( App ) knock-in mouse models recapitulate...
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Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein
In multiple system atrophy (MSA), the protein α-synuclein misfolds into a prion conformation that self-templates and causes progressive...
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Regulatory roles of alternative splicing at Ezh2 gene in mouse oocytes
BackgroundEnhancer of zeste homologue 2 (EZH2), the core member of polycomb repressive complex 2 (PRC2), has multiple splicing modes and performs...
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AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy
BackgroundArrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an...
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Mouse IgA modulates human gut microbiota with inflammatory bowel disease patients
BackgroundThe imbalance of commensal bacteria is called dysbiosis in intestinal microflora. Secreted IgA in the intestinal lumen plays an important...
