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Flaxseed oil fraction reverses cardiac remodeling at a molecular level: improves cardiac function, decreases apoptosis, and suppresses miRNA-29b and miRNA 1 gene expression
Flaxseed is an ancient commercial oil that historically has been used as a functional food to lower cholesterol levels. However, despite its...
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The non-steroidal mineralocorticoid receptor antagonist finerenone and heart failure with preserved ejection fraction
Finerenone is a novel non-steroidal mineralocorticoid receptor (MR) antagonist (MRA) with high binding affinity, high MR selectivity and a short...
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Chemical profiling and cytotoxic potential of the n-butanol fraction of Tamarix nilotica flowers
BackgroundCancer represents one of the biggest healthcare issues confronting humans and one of the big challenges for scientists in trials to dig...
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Native T1 high region and left ventricular ejection fraction recovery in patients with dilated cardiomyopathy
Native T1 map** is used to assess myocardial tissue characteristics without gadolinium contrast agents. The focal T1 high-intensity region can...
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Renoprotective activity of anethole- rich fraction from aromatic herbs on junk food induced diabetic nephropathy in rats
PurposeThis study was carried out to study the effect of anethole rich fraction on the Diabetic Nephropathy (DN) rats, and explore the mechanisms.
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Defining the Phenotypes for Heart Failure With Preserved Ejection Fraction
Purpose of ReviewHeart failure with preserved ejection fraction (HFpEF) imposes a significant burden on society and healthcare. The lack in...
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Efficacy of adipose—derived stromal vascular fraction in treatment of osteoarthritis: an experimental study
BackgroundOsteoarthritis OA is a common progressive disabling disease. Current research aims at finding therapies to prevent its progression. In this...
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Deep learning-based thigh muscle segmentation for reproducible fat fraction quantification using fat–water decomposition MRI
BackgroundTime-efficient and accurate whole volume thigh muscle segmentation is a major challenge in moving from qualitative assessment of thigh...
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The efficacy and safety of adaptive servo-ventilation therapy for heart failure with preserved ejection fraction
It is unclear whether adaptive servo-ventilation (ASV) therapy for heart failure with preserved ejection fraction (HFpEF) is effective. The aim of...
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Influence of Gd-EOB-DTPA on proton-density fat fraction in the liver using chemical shift-encoded magnetic resonance imaging at 3-T
Non-alcoholic fatty liver disease (NAFLD) and its advanced stage, non-alcoholic steatohepatitis (NASH), have become increasingly prevalent owing to...
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Associations between vertebral bone marrow fat and sagittal spine alignment as assessed by chemical shift-encoding-based water–fat MRI
BackgroundThe relationship between sagittal spine alignment and vertebral bone marrow fat is unknown. We aimed to assess the relationship between...
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Chronic high-rate pacing induces heart failure with preserved ejection fraction-like phenotype in Ossabaw swine
The lack of pre-clinical large animal models of heart failure with preserved ejection fraction (HFpEF) remains a growing, yet unmet obstacle to...
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Heart Failure with Preserved Ejection Fraction: Pathogenesis, Diagnosis, Exercise, and Medical Therapies
Heart failure with preserved ejection fraction (HFpEF) accounts for more than one-half of total heart failure cases, with a high prevalence and poor...
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Influence of Gadoxetate disodium to the hepatic proton density fat fraction quantified with the Dixon sequences in a rabbit model
ObjectiveTo study the impact of Gx on quantification of hepatic fat contents under metabolic dysfunction-associated steatotic liver disease (MASLD)...
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Drug Therapy for Acute and Chronic Heart Failure with Preserved Ejection Fraction with Hypertension: A State-of-the-Art Review
In this comprehensive state-of-the-art review, we provide an evidence-based analysis of current drug therapies for patients with heart failure with...
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Extracellular free water elevations are associated with brain volume and maternal cytokine response in a longitudinal nonhuman primate maternal immune activation model
Maternal infection has emerged as an important environmental risk factor for neurodevelopmental disorders, including schizophrenia and autism...
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SGLT2 Inhibitors in Older Adults with Heart Failure with Preserved Ejection Fraction
Heart failure is an important medical condition that is prevalent in older adults. Multiple therapies have been identified that improve clinical...
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Automatic segmentation of the interscapular brown adipose tissue in rats based on deep learning using the dynamic magnetic resonance fat fraction images
ObjectiveThe study aims to propose an accurate labelling method of interscapular BAT (iBAT) in rats using dynamic MR fat fraction (FF) images with...
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Correlation of R2* with fat fraction and bone mineral density and its role in quantitative assessment of osteoporosis
ObjectivesTo investigate the correlation of R2* with vertebral fat fraction (FF) and bone mineral density (BMD), and to explore its role in the...
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Linearity and bias of proton density fat fraction across the full dynamic range of 0–100%: a multiplatform, multivendor phantom study using 1.5T and 3T MRI at two sites
ObjectivePerformance assessments of quantitative determinations of proton density fat fraction (PDFF) have largely focused on the range between 0 and...
