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Evolving Definitions of Palliative Care: Upstream Migration or Confusion?
Palliative care has evolved over the decades from its roots in the hospice movement to a much wider approach in which early intervention further...
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Downstream or upstream administration of P2Y12 receptor blockers in non-ST elevated acute coronary syndromes: study protocol for a randomized controlled trial
BackgroundThe optimal timing to administer a P2Y12 inhibitor in patients presenting with a non-ST elevation acute coronary syndrome remains a topic...
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Moving Upstream to Improve Children’s Mental Health Through Community and Policy Change
Using a social determinants of health framework, we argue that the majority of evidence-based interventions focused on child and adolescent mental...
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Expression of upstream and downstream targets of mTOR pathway in seven cases of secretory carcinoma of salivary gland origin
PurposeTo investigate the expression of upstream and downstream targets of mTOR signalling pathway in the secretory carcinoma of salivary gland...
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The role of miR-153 and related upstream/downstream pathways in cancers: from a potential biomarker to treatment of tumor resistance and a therapeutic target
MicroRNAs (miRNAs/miRs) are small non-coding RNAs that have a multifunction and play essential roles in gene regulation. Their dysregulation is...
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Clinical outcome is distinct between radiological stricture and endoscopic stricture in ileal Crohn’s disease
ObjectivesDifferences in clinical adverse outcomes (CAO) based on different intestinal stricturing definitions in Crohn’s disease (CD) are poorly...
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SATB2 and NGR1: potential upstream regulatory factors in uterine leiomyomas
PurposeWe attempted to identify the genes involved in the pathogenesis of uterine leiomyomas, under a hypothesis that the aberrant expression of...
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Assessment of intestinal luminal stenosis and prediction of endoscopy passage in Crohn’s disease patients using MRI
BackgroundCrohn’s disease (CD) is an inflammatory disease of the gastrointestinal tract. The disease behavior changes over time, and endoscopy is...
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Identification of schizophrenia symptom-related gene modules by postmortem brain transcriptome analysis
Schizophrenia is a multifactorial disorder, the genetic architecture of which remains unclear. Although many studies have examined the etiology of...
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What is the appropriate method of pathological specimen collection for cholangiocarcinoma detection in primary sclerosing cholangitis?
BackgroundIn primary sclerosing cholangitis (PSC), it is important to understand the cholangiographic findings suggestive of malignancy, but it is...
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Imaging and clinical predictors of surgery in stricturing ileal Crohn’s disease: a retrospective study from a large pediatric hospital
Purpose(1) To determine the frequency of surgical management in children with Crohn's Disease (CD) and a new radiologic ileal stricture, and (2) to...
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Moving prevention of functional impairment upstream: is middle age an ideal time for intervention?
To live independently, individuals must be able to perform basic activities of daily living (ADLs), including bathing, dressing, and transferring out...
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SOX9 gene shows association with adolescent idiopathic scoliosis predisposition in Northwest Indians
BackgroundAdolescent idiopathic scoliosis (AIS) is a common structural deformity of the spine affecting adolescent individuals globally. The disorder...
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Transcriptomic Expression of T2-Inflammation Genes in Peripheral Blood Mononuclear Cells and Longitudinal Clinical Outcomes in Asthma: Insights from the COREA Study
BackgroundGene expression can provide distinct information compared to clinical biomarkers in the context of longitudinal clinical outcomes in asthma...
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Potential relationship between high wall shear stress and plaque rupture causing acute coronary syndrome
The relationship between high wall shear stress (WSS) and plaque rupture (PR) in longitudinal and circumferential locations remains uncertain....
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Upregulation of BMP1 through ncRNAs correlates with adverse outcomes and immune infiltration in clear cell renal cell carcinoma
BackgroundRenal cell carcinoma (RCC) accounts for approximately 2–3% of all adult malignancies. Clear cell renal cell carcinoma (ccRCC), which...
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Roles and Mechanisms of miRNAs in Abdominal Aortic Aneurysm: Signaling Pathways and Clinical Insights
Purpose of ReviewAbdominal aortic aneurysm refers to a serious medical condition that can cause the irreversible expansion of the abdominal aorta,...
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Predictive enrichment for the need of renal replacement in sepsis-associated acute kidney injury: combination of furosemide stress test and urinary biomarkers TIMP-2 and IGFBP-7
BackgroundIn sepsis, initial resuscitation with fluids is followed by efforts to achieve a negative fluid balance. However, patients with...
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Different projection neurons of basolateral amygdala participate in the retrieval of morphine withdrawal memory with diverse molecular pathways
Context-induced retrieval of drug withdrawal memory is one of the important reasons for drug relapses. Previous studies have shown that different...
