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Oncostatin M triggers brain inflammation by compromising blood–brain barrier integrity
Oncostatin M (OSM) is an IL-6 family member which exerts neuroprotective and remyelination-promoting effects after damage to the central nervous...
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Identification of a novel m6A-related lncRNA pair signature for predicting the prognosis of gastric cancer patients
BackgroundAccumulating studies have demonstrated that lncRNAs play vital roles in the prognosis of gastric cancer (GC); however, the prognostic value...
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Relationship between Methylation of FHIT and CDH13 Gene Promoter Region and Liver Cancer
In order to demonstrate the relationship between methylation of fragile histidine triad (FHIT) and T-cadherin/H-cadherin (CDH13) genes and liver...
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Association between the Worst Pattern of Tumor Invasion and Epithelial-mesenchymal Transition and their Prognostic Impact on Early-stage Oral Tongue Squamous Cell Carcinoma
PurposeWe aimed to determine the association between the worst pattern of tumor invasion (WPOI) and epithelial-mesenchymal transition (EMT) in...
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YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression
The hallmark of epithelial-to-mesenchymal transition (EMT) is the switch from epithelial cadherin (E-cadherin) to neural cadherin (N-cadherin),...
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LncRNA MEG3 Inhibits the Epithelial-mesenchymal Transition of Bladder Cancer Cells through the Snail/E-cadherin Axis
ObjectiveThis study aimed to investigate the role of the long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) in the epithelial-mesenchymal...
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Tuberculous pleural effusion-induced Arg-1+ macrophage polarization contributes to lung cancer progression via autophagy signaling
BackgroundThe association between tuberculous fibrosis and lung cancer development has been reported by some epidemiological and experimental...
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Unique Cohorts of Salivary Gland Cancer Cells as an in-vitro Model of Circulating Tumor Cells
IntroductionThe characterization of circulating tumor cells (CTC) and circulating tumor microemboli (CTM) has emerged as both a challenge to the...
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Multi-omics analysis reveals NNMT as a master metabolic regulator of metastasis in esophageal squamous cell carcinoma
Metabolic reprogramming has been observed in cancer metastasis, whereas metabolic changes required for malignant cells during lymph node metastasis...
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CADM2 participates in endometriosis development by influencing the epithelial-mesenchymal transition
Endometriosis (EM) is a common gynecologic condition that often leads to infertility in women of reproductive age. Cell adhesion molecule 2 (CADM2)...
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IL-17 crosses the blood–brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine
BackgroundChronic migraine places a disabling burden on patients, which is extensively modeled by the nitroglycerin (NTG)-treated animal model....
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Association between the expression of epithelial–mesenchymal transition (EMT)-related markers and oncologic outcomes of colorectal cancer
BackgroundEpithelial–mesenchymal transition (EMT) is a key step in the development of colorectal cancer (CRC) that confers metastatic capabilities to...
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Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma
Polo-like kinase 1 (PLK1), a serine/threonine kinase, is overexpressed in melanoma and its expression has been associated with poor disease...
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Targeting lysyl oxidase like 2 attenuates OVA-induced airway remodeling partly via the AKT signaling pathway
BackgroundAirway epithelium is an important component of airway structure and the initiator of airway remodeling in asthma. The changes of...
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The induction strategies administered in the treatment of multiple myeloma exhibit a deleterious effect on the endothelium
Multiple myeloma induction treatment includes proteasome inhibitors (PI) and immunomodulatory agents at present. The incidence of engraftment...
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Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation
BackgroundMacrophage migration inhibitory factor (MIF) and GTPase dynamin-related protein 1 (Drp1)-dependent aberrant mitochondrial fission are...
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Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates ZEB2 to boost NSCLC development by activating EMT
BackgroundCircular RNAs (circRNAs) are critical regulators in the progression of tumors. This experimental design aimed to explore the mechanism of...
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Individualized lncRNA differential expression profile reveals heterogeneity of breast cancer
Long non-coding RNAs (lncRNAs) play key regulatory roles in breast cancer. However, population-level differential expression analysis methods...
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HIV gp120/Tat protein-induced epithelial–mesenchymal transition promotes the progression of cervical lesions
BackgroundHuman immunodeficiency virus (HIV) infection is associated with an elevated incidence of cervical cancer, and accelerated disease...
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Expression and significance of SIRT6 in human peritoneal dialysis effluents and peritoneal mesothelial cells
Sirtuin 6 (SIRT6) can inhibit the fibrosis of many organs. However, the relationship between SIRT6 and peritoneal fibrosis (PF) in peritoneal...
