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Toward Genetic Testing of Rivaroxaban? Insights from a Systematic Review on the Role of Genetic Polymorphism in Rivaroxaban Therapy
BackgroundInvestigations into the rivaroxaban response from the perspective of genetic variation have been relatively recent and wide in scope,...
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Pharmacogenomic testing for antidepressant treatment selection: lessons learned and roadmap forward
Pharmacogenomic technology is a develo** field with enthusiastic interest and broad application potential. Three large, controlled studies have...
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The perception of genetic diseases and premarital screening tests in the central region of Saudi Arabia
The prevalence of consanguineous marriages (CMs) varies worldwide from one country to another. However, the Middle East stands out as a region with a...
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The genetic landscape of substance use disorders
Substance use disorders represent a significant public health concern with considerable socioeconomic implications worldwide. Twin and family-based...
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Phylogenetically evolutionary analysis provides insights into the genetic diversity and adaptive evolution of porcine deltacoronavirus
BackgroundPorcine deltacoronavirus (PDCoV) is one of the emerging swine enteric coronaviruses (SECoVs), which has been widely prevalent in the North...
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Sex differences in energy metabolism: natural selection, mechanisms and consequences
Metabolic homeostasis operates differently in men and women. This sex asymmetry is the result of evolutionary adaptations that enable women to resist...
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Work participation in adults with rare genetic diseases - a sco** review
BackgroundWork participation is a crucial aspect of health outcome and an important part of life for most people with rare genetic diseases. Despite...
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Chromosomal segregation analysis and HOST-based sperm selection in a complex reciprocal translocation carrier
IntroductionComplex chromosomal rearrangements (CCRs) involve two or more chromosomes and at least three breakpoints. Due to their complexity, they...
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Genetic architecture of childhood speech disorder: a review
Severe speech disorders lead to poor literacy, reduced academic attainment and negative psychosocial outcomes. As early as the 1950s, the familial...
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Clinical characteristics indexing genetic differences in bipolar disorder – a systematic review
Bipolar disorder is a heterogenous condition with a varied clinical presentation. While progress has been made in identifying genetic variants...
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Classification of cancer cells and gene selection based on microarray data using MOPSO algorithm
PurposeMicroarray information is crucial for the identification and categorisation of malignant tissues. The very limited sample size in the...
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A Systematic Review on the Genetic Contribution to Tinnitus
PurposeTo assess the available evidence to support a genetic contribution and define the role of common and rare variants in tinnitus.
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New frontiers in embryo selection
Human infertility is a major global public health issue estimated to affect one out of six couples, while the number of assisted reproduction cycles...
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Preimplantation genetic testing in the current era, a review
BackgroundPreimplantation genetic testing (PGT), also referred to as preimplantation genetic diagnosis (PGD), is an advanced reproductive technology...
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Genetic profile of syndromic retinitis pigmentosa in Portugal
PurposeRetinitis pigmentosa (RP) comprises a genetically and clinically heterogeneous group of inherited retinal degenerations, where 20–30% of...
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Geographical and temporal dynamics of genetic diversity of Plasmodium falciparum merozoite surface proteins 1/2 in India
The high genetic diversity of Plasmodium falciparum ( Pf ) is a big obstacle to successful vaccine development programs. Here, the geographical and...
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Genetic diversity of merozoite surface protein-5 (MSP-5) of Plasmodium vivax isolates from Malaria patients in Iran
Malaria has not yet been eradicated in Iran, and Plasmodium vivax ( P. vivax ) is the main cause of malaria in the country. This study aimed to...
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Selecting cases of major psychiatric and substance use disorders in Swedish national registries on the basis of clinical features to maximize the strength or specificity of the genetic risk
We investigate how selection of psychiatric cases by phenotypic criteria can alter the strength and specificity of their genetic risk by examining...
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Development of an interpretable machine learning model associated with genetic indicators to identify Yin-deficiency constitution
BackgroundTraditional Chinese Medicine (TCM) defines constitutions which are relevant to corresponding diseases among people. As one of the common...
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Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study
Identifying mechanisms underlying the intergenerational transmission of risk for attention-deficit/hyperactivity disorder (ADHD) traits can inform...
