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Association Between RAS/BRAF Mutations and Complete Response Following Total Neoadjuvant Therapy in Patients with Rectal Cancer: A Prospective Multicentered Study
BackgroundThe impact of RAS/BRAF mutation on primary response rates after total neoadjuvant therapy (TNT) in patients with advanced rectal cancer is...
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A narrative review of the Medtronic Hugo RAS and technical comparison with the Intuitive da Vinci robotic surgical system
Medtronic launched the Hugo Robotic-Assisted Surgery (RAS) System in 2021, offering a modular alternative to the incumbent market leader in surgical...
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Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP
The combination of KRAS G12C inhibitors with EGFR inhibitors has reproducibly been shown to be beneficial. Here, we identify another benefit of this...
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Machine learning and radiomics analysis by computed tomography in colorectal liver metastases patients for RAS mutational status prediction
PurposeTo assess the efficacy of machine learning and radiomics analysis by computed tomography (CT) in presurgical setting, to predict RAS...
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Da Vinci vs. Hugo RAS for robot-assisted radical prostatectomy: a prospective comparative single-center study
PurposeTo evaluate Hugo RAS against the Da Vinci system for Robot-Assisted Radical Prostatectomy (RARP) in prostate cancer treatment.
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GPS2 ameliorates cigarette smoking-induced pulmonary vascular remodeling by modulating the ras-Raf-ERK axis
BackgroundMitogen-activated protein kinase (MAPK)signaling-mediated smoking-associated pulmonary vascular remodeling (PVR) plays an important role in...
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Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma
The oncogene Ras and the tumor suppressor gene p53 are frequently co-mutated in human cancer and mutations in Ras and p53 can cooperate to generate a...
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Colorectal procedures with the novel Hugo™ RAS system: training process and case series report from a non-robotic surgical team
BackgroundThe landscape of robotic surgery is evolving with the emergence of new platforms. However, reports on their applicability in different...
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Efficacy of Regorafenib and Trifluridine/Tipiracil According to Extended RAS Evaluation in Advanced Metastatic Colorectal Cancer Patients: A Multicenter Retrospective Analysis
BackgroundThere are few molecular markers driving treatment selection in later lines of treatment for advanced colorectal cancer patients. The vast...
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Performance and learning rate prediction models development in FLS and RAS surgical tasks using electroencephalogram and eye gaze data and machine learning
ObjectiveThis study explored the use of electroencephalogram (EEG) and eye gaze features, experience-related features, and machine learning to...
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Novel effects of Ras-MAPK pathogenic variants on the develo** human brain and their link to gene expression and inhibition abilities
The RASopathies are genetic syndromes associated with pathogenic variants causing dysregulation of the Ras/mitogen-activated protein kinase...
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Cost analysis of new robotic competitors: a comparison of direct costs for initial hospital stay between Da Vinci and Hugo RAS for radical prostatectomy
Robotic surgery with Da Vinci has revolutionized the treatment of several diseases, including prostate cancer; nevertheless, costs remain the major...
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Rechallenge with Anti-EGFR Treatment in RAS/BRAF wt Metastatic Colorectal Cancer (mCRC) in Real Clinical Practice: Experience of the GITuD Group
BackgroundThere are few third- and fourth-line therapeutic options for metastatic colorectal cancer (mCRC). In RAS/BRAF wild-type (wt) mCRC...
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Preoperative Risk Stratification of Follicular-patterned Thyroid Lesions on Core Needle Biopsy by Histologic Subty** and RAS Variant-specific Immunohistochemistry
Follicular-patterned lesions often have indeterminate results (diagnostic category III or IV) by core needle biopsy (CNB) and fine needle aspiration...
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RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging
PurposeMacropinocytosis serves as a highly conserved endocytotic process that has recently been shown as a critical mechanism by which...
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Initial experience of robot-assisted partial nephrectomy with Hugo™ RAS system: implications for surgical setting
PurposeHugo™ RAS system is one of the most promising new robotic platforms introduced in the field of urology. To date, no data have been provided on...
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Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer
PurposeSome patients with histologically confirmed primary mCRC and mutated RAS reported undetectable RAS mutant clones in plasma after receiving...
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TSPAN6 is a suppressor of Ras-driven cancer
Oncogenic mutations in the small GTPase RAS contribute to ~30% of human cancers. In a Drosophila genetic screen, we identified novel and evolutionary...
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Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies
Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality, underscores the urgent need for enhanced insights into the...
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Selecting Optimal First-Line Treatment for Microsatellite Stable and Non-Mutated RAS/BRAF Metastatic Colorectal Cancer
Standard frontline treatment of metastatic colorectal cancer (CRC) is cytotoxic chemotherapy plus a biologic agent such as an anti-EGFR monoclonal...
