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NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin
BackgroundIdiopathic pulmonary fibrosis is a persistent disease of the lung interstitium for which there is no efficacious pharmacological therapy....
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[18 F] -FAPI-42 PET/CT assessment of Progressive right ventricle fibrosis under pressure overload
BackgroundRight heart failure (RHF) is a complication of pulmonary hypertension (PH) and increases the mortality independently of the underlying...
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Antifibrotic mechanism of avitinib in bleomycin-induced pulmonary fibrosis in mice
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by alveolar epithelial cell injury and lung...
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Efficacy of antifibrotic drugs, nintedanib and pirfenidone, in treatment of progressive pulmonary fibrosis in both idiopathic pulmonary fibrosis (IPF) and non-IPF: a systematic review and meta-analysis
BackgroundResearch questions To compare the efficacy of nintedanib and pirfenidone in the treatment of progressive pulmonary fibrosis; and to...
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Circular RNAs and their roles in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited treatment options. Circular RNAs (circRNAs) have emerged as...
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Short Telomere Syndrome presenting with pulmonary fibrosis, liver cirrhosis and hepatopulmonary syndrome: a case report
BackgroundIdiopathic pulmonary fibrosis is thought to result from aberrant post-injury activation of epithelial cells leading to fibroblast...
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Trigonelline hydrochloride attenuates silica-induced pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation
BackgroundSilicosis represents a paramount occupational health hazard globally, with its incidence, morbidity, and mortality on an upward trajectory,...
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Pulmonary Fibrosis Diagnosis and Disease Progression Detected Via Hair Metabolome Analysis
BackgroundFibrotic interstitial lung disease is often identified late due to non-specific symptoms, inadequate access to specialist care, and...
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Tetrandrine slows the radiographic progression of progressive massive fibrosis in pneumoconiosis: a retrospective cohort study
ObjectiveThis study aims to explore the clinical effect of Tetrandrine (Tet) on progressive massive fibrosis (PMF) of pneumoconiosis.
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Identification of non-coding RNA signatures in idiopathic pulmonary fibrosis
BackgroundIdiopathic pulmonary fibrosis (IPF) is a deadly, chronic, progressive, irreversible interstitial lung disease characterized by the...
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Prolyl oligopeptidase inhibition ameliorates experimental pulmonary fibrosis both in vivo and in vitro
BackgroundPulmonary fibrosis is a progressive disease characterized by lung remodeling due to excessive deposition of extracellular matrix. Although...
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Olfactory mucosa mesenchymal stem cells alleviate pulmonary fibrosis via the immunomodulation and reduction of inflammation
BackgroundPulmonary fibrosis (PF) is a progressive fibrosing interstitial pneumonia that leads to respiratory failure and other complications, which...
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Assessment of lung deformation in patients with idiopathic pulmonary fibrosis with elastic registration technique on pulmonary three-dimensional ultrashort echo time MRI
ObjectiveTo assess lung deformation in patients with idiopathic pulmonary fibrosis (IPF) using with elastic registration algorithm applied to...
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Deficiency of HtrA3 Attenuates Bleomycin-Induced Pulmonary Fibrosis Via TGF-β1/Smad Signaling Pathway
PurposeIdiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by excessive extracellular matrix...
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Molecular Mechanisms Underlying Systemic Sclerosis–Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: an Update
Purpose of reviewSystemic sclerosis–associated interstitial lung disease (SSc-ILD) and idiopathic pulmonary fibrosis (IPF) are fatal fibrotic lung...
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The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin
BackgroundAt present, the treatment options available for idiopathic pulmonary fibrosis are both limited and often come with severe side effects,...
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Post-COVID-19 Pulmonary Fibrosis: Facts—Challenges and Futures: A Narrative Review
Patients with coronavirus disease 2019 (COVID-19) usually suffer from post-acute sequelae of coronavirus disease 2019 (PASC). Pulmonary fibrosis (PF)...
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IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis
BackgroundPulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in...
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Simvastatin attenuates silica-induced pulmonary inflammation and fibrosis in rats via the AMPK-NOX pathway
BackgroundSimvastatin (Sim), a hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has been widely used in prevention and treatment of...
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Pulmonary fibrosis model of mice induced by different administration methods of bleomycin
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease of the lung. How to build a typical human mimicking animal model has...
