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RT-QuIC detection of chronic wasting disease prion in platelet samples of white-tailed deer
BackgroundChronic wasting disease (CWD) is a prion disease of captive and free-ranging cervids. Currently, a definitive diagnosis of CWD relies on...
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The critical role of platelet in cancer progression and metastasis
Platelets play a crucial role in cancer blood metastasis. Various cancer-related factors such as Toll-like receptors (TLRs), adenosine diphosphate...
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Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia—an exploratory study
BackgroundCirculating extracellular vesicles (EVs) are increased in preeclampsia (PE) and are associated with severity and progression. We examined...
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Comparison of the effects of the GPIIb-IIIa antagonist Zalunfiban and the P2Y12 antagonist Selatogrel on Platelet Aggregation
Understanding the pharmacodynamic effects of platelet inhibitors is standard for develo** more effective antithrombotic therapies. An example is...
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Sodium bicarbonate as a local adjunctive agent for limiting platelet activation, aggregation, and adhesion within cardiovascular therapeutic devices
Cardiovascular therapeutic devices (CTDs) remain limited by thrombotic adverse events. Current antithrombotic agents limit thrombosis partially,...
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Time from blood draw to multiple electrode aggregometry and association with platelet reactivity
Results from multiple electrode aggregometry (MEA) may vary according to pre-analytic factors. This study aimed to analyze the association of time...
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Platelet lysate for the treatment of osteoarthritis: a systematic review of preclinical and clinical studies
Intra-articular injection-based therapy is often used aside conservative treatment and lifestyle modifications to manage knee osteoarthritis (KO)...
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Platelet-derived microvesicles (PMVs) in cancer progression and clinical applications
Platelet-derived microvesicles (PMVs), the microvesicles with the highest concentration in the bloodstream, play a key role in the regulation of...
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Treatment of platelet concentrates with the L-carnitine modulates platelets oxidative stress and platelet apoptosis due to mitochondrial reactive oxygen species reduction and reducing cytochrome C release during storage
Platelet concentrate (PC) transfusion is administrated to reduce the hemostatic complications in patients with thrombocytopenia. Strength platelet...
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Quality Analysis of Autologous Platelet-Rich Plasmapheresis
To summarized the technology of autologous platelet-rich plasmapheresis and analyzed the product quality, in order to provide safe and effective...
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Impact of platelet transfusion on outcomes in trauma patients
BackgroundTrauma-induced coagulopathy includes thrombocytopenia and platelet dysfunction that impact patient outcome. Nevertheless, the role of...
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Changes in Complement Levels and Activity of Red Blood Cells, Fresh Frozen Plasma, and Platelet Concentrates During Storage
Complement cascade plays an important role in the field of transfusion medicine. The study aimed to detect the complement levels of different blood...
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Can we lower the platelet threshold of ≥ 50 × 109/L for performing a lumbar puncture safely in patients with hematological malignancies?
Lumbar punctures (LP) are routinely used to administer intrathecal chemotherapy for children and adults with hematologic malignancies. The current...
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Von Willebrand Factor and Platelet Aggregation: from Bench to Clinical Practice
Purpose of ReviewThis review describes von Willebrand factor (VWF)-mediated platelet function in inherited and acquired bleeding disorders, and...
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Treatment of bronchial anastomotic fistula using autologous platelet-rich plasma post lung transplantation
BackgroundBronchial anastomotic dehiscence is considered one of the most catastrophic early airway complications post-transplant. The presence of a...
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Glycogen storage diseases
Glycogen storage diseases (GSDs) are a group of rare, monogenic disorders that share a defect in the synthesis or breakdown of glycogen. This Primer...
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Circadian variations of platelet reactivity on clopidogrel in patients treated with elective percutaneous coronary intervention
Evidence assessing potential diurnal variations of platelet reactivity in patients on clopidogrel treated with elective percutaneous coronary...
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Freeze-dried noncoagulating platelet-derived factor concentrate is a safe and effective treatment for early knee osteoarthritis
PurposeWhile a wide variety of platelet-rich plasma (PRP) solutions has been developed, innovation continues. In this case, the freeze-dried platelet...
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Platelet-rich plasma injection for the treatment of ankle osteoarthritis: a systematic review and meta-analysis
BackgroundPlatelet-rich plasma (PRP) injection for ankle osteoarthritis (OA) treatment showed contradictory results. This review was aimed to pool...
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Partial splenic artery embolization (PSE) in a patient with grey platelet syndrome (GPS): a case report
BackgroundGrey platelet syndrome (GPS) is a rare cause of mild-to-severe bleeding. Up till now, there has been no definite treatment for GPS.
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