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Emergency department occupancy is useful as a simple real-time measure of crowding
IntroductionEmergency department (ED) crowding compromises patient outcomes. Existing crowding measures are complex and difficult to use in...
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Novel Gut Microbiota Modulator, Which Markedly Increases Akkermansia muciniphila Occupancy, Ameliorates Experimental Colitis in Rats
BackgroundSince gut microbiota is involved in the pathogenesis of inflammatory bowel disease (IBD), antibiotics or probiotics may be attractive...
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Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A
BackgroundAntiepileptic drugs, levetiracetam (LEV) and brivaracetam (BRV), bind to synaptic vesicle glycoprotein 2A (SV2A). In their anti-seizure...
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Single Room Occupancy Residence: Processes Linking Housing to Not Engaging in HIV Outpatient Care
Homelessness and housing instability undermine engagement in medical care, adherence to treatment and health among persons with HIV/AIDS. However,...
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Occupancy of the kappa opioid receptor by naltrexone predicts reduction in drinking and craving
The efficacy of naltrexone to treat alcohol use disorder (AUD) is modest. A better understanding of the neurobiology underlying naltrexone effects...
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Association between intensive care unit occupancy at discharge, afterhours discharges, and clinical outcomes: a historical cohort study
PurposeThere is a paucity of evidence evaluating whether intensive care unit (ICU) discharge occupancy is associated with clinical outcomes. It is...
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Effect of 5-HT2A receptor antagonism on levels of D2/3 receptor occupancy and adverse behavioral side-effects induced by haloperidol: a SPECT imaging study in the rat
Several studies suggested that 5-HT 2A receptor (5-HT 2A R) blockade may provide a more favorable efficacy and side-effect profile to antipsychotic...
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Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study
PurposePridopidine is an investigational drug for Huntington disease (HD). Pridopidine was originally thought to act as a dopamine stabilizer....
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Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain
BackgroundAvailability of the α 2C -adrenoceptor (α 2C -AR) positron emission tomography (PET) tracer, [ 11 C]ORM-13070, and the α 2C -AR antagonist...
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Overcoming denominator problems in refugee settings with fragmented electronic records for health and immigration data: a prediction-based approach
BackgroundEpidemiological studies in refugee settings are often challenged by the denominator problem, i.e. lack of population at risk data. We...
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Pharmacological Basis of Differences in Dose Response, Dose Equivalence, and Duration of Action of Inhaled Corticosteroids
IntroductionAsthma treatment guidelines classify inhaled corticosteroid (ICS) regimens as low, medium, or high dose. However, efficacy and safety are...
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Relationship between intensive care surge capacity and hospital factors: an extensive experience
As a prolonged surge scenario, the COVID-19 pandemic has offered an unparalleled opportunity to improve hospital surge capacity (SC) understanding...
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Spatial relationships among offender, knife, and victim during slashing attacks: implications for crime scene reconstruction
BackgroundThe offender-victim spatial relationship is crucial in reconstructing a crime scene. The study aims to evaluate the spatial relationship of...
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Evaluating the Patient Boarding during Omicron Surge in Hong Kong: Time Series Analysis
The fifth wave of COVID-19 outbreaks in Hong Kong (HK) from January to March 2022 has the highest confirmed cases and deaths compared with previous...
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Simultaneous single-position lateral interbody fusion and percutaneous pedicle screw fixation using O-arm-based navigation reduces the occupancy time of the operating room
PurposeLateral interbody fusion and posterior percutaneous pedicle screw (LIF-PPS) fixation has been performed in two-stage positioning. The aim of...
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Decreased patient discharges on weekends part 1: what do the data tell us?
BackgroundWe believe that hospital and emergency department (ED) crowding is exacerbated on Mondays because fewer in-patients are discharged on the...
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Association of intensive care unit occupancy during admission and inpatient mortality: a retrospective cohort study
PurposeThere is conflicting evidence regarding the influence of intensive care unit (ICU) occupancy at the time of admission on important patient...
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Survival among people hospitalized with COVID-19 in Switzerland: a nationwide population-based analysis
BackgroundIncreasing age, male sex, and pre-existing comorbidities are associated with lower survival from SARS-CoV-2 infection. The interplay...
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A quality improvement study on how a simulation model can help decision making on organization of ICU wards
BackgroundIntensive Care Unit (ICU) capacity management is essential to provide high-quality healthcare for critically ill patients. Yet, consensus...
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Impact of the COVID-19 pandemic on critical care utilization in Japan: a nationwide inpatient database study
BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has disrupted critical care services worldwide. Examining how critical care systems...
