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Sedation Effects Produced by a Ciprofol Initial Infusion or Bolus Dose Followed by Continuous Maintenance Infusion in Healthy Subjects: A Phase 1 Trial
IntroductionThe effects of continuous infusions of ciprofol on its pharmacodynamic and pharmacokinetic properties and safety profiles in healthy...
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Key elements and contextual factors that influence successful implementation of large-system transformation initiatives in the New Zealand health system: a realist evaluation
BackgroundDespite three decades of policy initiatives to improve integration of health care, delivery of health care in New Zealand remains...
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The scientific rationale and study protocol for the DPP3, Angiotensin II, and Renin Kinetics in Sepsis (DARK-Sepsis) randomized controlled trial: serum biomarkers to predict response to angiotensin II versus standard-of-care vasopressor therapy in the treatment of septic shock
BackgroundData to support the use of specific vasopressors in septic shock are limited. Since angiotensin II (AT2) was approved by the Food and Drug...
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The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection—study protocol for a two-stage randomised phase II trial
BackgroundAntiretroviral therapy (ART) has led to dramatic improvements in survival for people living with HIV, but is unable to cure infection, or...
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Current challenges and practical aspects of molecular pathology for bone and soft tissue tumors
This review shows the extraordinary change molecular pathology has induced in the classification, diagnosis, and clinical practice of molecular...
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Population Pharmacokinetics of Inotuzumab Ozogamicin in Pediatric Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia: Results of Study ITCC-059
Background and ObjectiveInotuzumab ozogamicin is an antibody-drug conjugate approved for treating relapsed/refractory B-cell precursor acute...
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Population Pharmacokinetics of Total and Unbound Isavuconazole in Critically Ill Patients: Implications for Adaptive Dosing Strategies
Background and ObjectivesIsavuconazole is a broad-spectrum antifungal agent for the management of invasive fungal disease. Optimised drug exposure is...
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Switching to brolucizumab: injection intervals and visual, anatomical and safety outcomes at 12 and 18 months in real-world eyes with neovascular age-related macular degeneration
BackgroundThe anti-vascular endothelial growth factor (anti-VEGF) injection interval influences treatment burden and compliance in neovascular...
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Integration of a task strengthening strategy for hypertension management into HIV care in Nigeria: a cluster randomized controlled trial study protocol
BackgroundIn regions with weak healthcare systems, critical shortages of the healthcare workforce, and increasing prevalence of dual disease burdens,...
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dCas9/CRISPR-based methylation of O-6-methylguanine-DNA methyltransferase enhances chemosensitivity to temozolomide in malignant glioma
BackgroundMalignant glioma carries a poor prognosis despite current therapeutic modalities. Standard of care therapy consists of surgical resection,...
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Sex Differences Between Female and Male Individuals in Antipsychotic Efficacy and Adverse Effects in the Treatment of Schizophrenia
Background and ObjectiveAntipsychotics are core treatments for people living with psychotic disorders. Understanding individualised factors that...
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Remote evaluation of sleep to enhance understanding of early dementia due to Alzheimer’s Disease (RESTED-AD): an observational cohort study protocol
BackgroundSleep and circadian rhythm disorders are well recognised in both AD (Alzheimer’s Disease) dementia and MCI-AD (Mild Cognitive Impairment...
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Tuberous sclerosis complex mutations in patients with pancreatic neuroendocrine tumors. Observations on phenotypic and treatment-related associations
Pancreatic neuroendocrine tumors (PanNETs) in familial tuberous sclerosis ( TSC 1 and TSC 2 mutations) have been known and studied. However, little is...
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Dihydroartemisinin-piperaquine or sulphadoxine-pyrimethamine for the chemoprevention of malaria in children with sickle cell anaemia in eastern and southern Africa (CHEMCHA): a protocol for a multi-centre, two-arm, double-blind, randomised, placebo-controlled superiority trial
BackgroundAn estimated 300,000 babies are born with sickle cell anaemia (SCA) annually. Affected children have chronic ill health and suffer...
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Exome sequencing analysis of gastric primary myeloid sarcoma with monocytic differentiation with altered immunophenotype after chemotherapy: case report
BackgroundMyeloid Sarcoma with monocytic differentiation is rare and quite likely is missed by surgical pathologists. However it is frequently...
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Guidelines for the treatment of chronic myeloid leukemia from the NCCN and ELN: differences and similarities
Patients diagnosed with chronic myeloid leukemia (CML) in chronic phase can now have a life expectancy comparable to that of the general population...
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A study protocol for Project I-Test: a cluster randomized controlled trial of a practice coaching intervention to increase HIV testing in substance use treatment programs
BackgroundPeople with substance use disorders are vulnerable to acquiring HIV. Testing is fundamental to diagnosis, treatment, and prevention;...
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Ringworm in calves: risk factors, improved molecular diagnosis, and therapeutic efficacy of an Aloe vera gel extract
BackgroundDermatophytosis in calves is a major public and veterinary health concern worldwide because of its zoonotic potential and associated...
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A sco** review of de-implementation frameworks and models
BackgroundReduction or elimination of inappropriate, ineffective, or potentially harmful healthcare services and public health programs can help to...
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Effects of Food and Liquid Properties on Swallowing Physiology and Function in Adults
Foods and liquids have properties that are often modified as part of clinical dysphagia management to promote safe and efficient swallowing. However,...
