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Identification of necroptosis-related long non-coding RNAs prognostic signature and the crucial lncRNA in bladder cancer
BackgroundResearch on the relationships between long non-coding RNAs (lncRNAs) and cancer is attractive and has progressed very rapidly....
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MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes
BackgroundCardiomyocyte death contributes to cardiac pathology of diabetes. Studies have shown that the RIPK3/MLKL necroptosis signaling is activated...
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Activation of necroptosis pathway in podocyte contributes to the pathogenesis of focal segmental glomerular sclerosis
BackgroundFocal segmental glomerulosclerosis (FSGS) is characterized by podocyte damage and severe proteinuria. The exact mechanism of podocyte...
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Polyphyllin D induces necroptosis in neuroblastoma cells (IMR-32 and LA-N-2) in mice
BackgroundWe previously reported that polyphyllin D, the main component of the traditional herbal medicinal Paris polyphylla , exhibited anticancer...
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Necroptosis-Related LncRNA Signatures for Prognostic Prediction in Uterine Corpora Endometrial Cancer
Necroptosis is one of the common modes of apoptosis, and it has an intrinsic association with cancer prognosis. However, the role of the...
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Construction of a novel necroptosis-related lncRNA signature for prognosis prediction in esophageal cancer
BackgroundEsophageal cancer (EC), one highly malignant gastrointestinal cancer, is the 6th leading cause of cancer-related deaths worldwide....
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A novel necroptosis-related long non-coding RNA signature predicts prognosis and immune response in cervical cancer patients
BackgroundNecroptosis has been linked to the development of tumors. Long non-coding RNAs (IncRNAs) have been identified as having a major role in...
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Identification of a necroptosis-related prognostic gene signature associated with tumor immune microenvironment in cervical carcinoma and experimental verification
Cervical carcinoma (CC) has been associated with high morbidity, poor prognosis, and high intratumor heterogeneity. Necroptosis is the significant...
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Predicting the prognosis of hepatocellular carcinoma based on the interaction between pyroptosis, apoptosis, and necroptosis
Multiple programmed cell death pathways (pyroptosis, apoptosis, and necroptosis) are closely related to the progression of hepatocellular carcinoma...
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Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research
Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called...
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Fisetin-induced cell death in human ovarian cancer cell lines via zbp1-mediated necroptosis
BackgroundAmong reproductive cancers, ovarian cancer leads to the highest female mortality rate. Fisetin, a natural flavonoid, exerts pharmacological...
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Identification and validation of necroptosis-related prognostic gene signature and tumor immune microenvironment infiltration characterization in esophageal carcinoma
BackgroundEsophageal carcinoma (ESCA) is a common malignancy with a poor prognosis. Previous research has suggested that necroptosis is involved in...
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Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia
Necroptosis is a novel form of programmed necrotic cell death involved in various autoimmune diseases. The potential role of necroptosis in primary...
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Pan-cancer analysis of necroptosis-related gene signature for the identification of prognosis and immune significance
BackgroundNecroptosis is a novel programmed cell death mode independent on caspase. A number of studies have revealed that the induction of...
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RIP3 knockdown inhibits necroptosis of human intestinal epithelial cells via TLR4/MyD88/NF-κB signaling and ameliorates murine colitis
BackgroundUlcerative colitis (UC) is a common inflammatory bowel disease, during which cell necroptosis plays key roles in driving inflammation...
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Necroptosis in biliary atresia of the liver
Biliary atresia (BA) is characterized by the occlusion of extrahepatic bile ducts due to sclerosing inflammation. Necroptosis is a recently...
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Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis: Mechanisms and Clinical Applications in Ischemic Stroke
Ischemic stroke is a serious cerebrovascular disease with high morbidity and mortality. As a result of ischemia-reperfusion, a cascade of...
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Arylamine N-acetyltransferase 1 deficiency inhibits drug-induced cell death in breast cancer cells: switch from cytochrome C-dependent apoptosis to necroptosis
PurposeArylamine N -acetyltransferase 1 (NAT1) deficiency has been associated with drug resistance and poor outcomes in breast cancer patients. The...
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Bufalin Induces Programmed Necroptosis in Triple-Negative Breast Cancer Drug-Resistant Cell Lines through RIP1/ROS-Mediated Pathway
ObjectiveTo explore the effect and mechanism of action of bufalin in triple-negative breast cancer (TNBC) drug-resistant cell lines.
Methods ...