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PDHA1 Alleviates Myocardial Ischemia-Reperfusion Injury by Improving Myocardial Insulin Resistance During Cardiopulmonary Bypass Surgery in Rats
ObjectiveCardiopulmonary bypass (CPB) is a requisite technique for thoracotomy in advanced cardiovascular surgery. However, the consequent myocardial...
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Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord
Lysophosphatidic acid (LPA) is a bioactive phospholipid that plays a crucial role in cardiovascular diseases. Here, we question whether LPA...
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Circulating exosomal mir-16-2-3p is associated with coronary microvascular dysfunction in diabetes through regulating the fatty acid degradation of endothelial cells
BackgroundCoronary microvascular dysfunction (CMD) is a frequent complication of diabetes mellitus (DM) characterized by challenges in both diagnosis...
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Mechanisms linking bariatric surgery to adipose tissue, glucose metabolism, fatty liver disease and gut microbiota
PurposeIn the last 20 years, bariatric surgery has achieved an important role in translational and clinical research because of obesity...
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Metabolism disorder promotes isoproterenol-induced myocardial injury in mice with high temperature and high humidity and high-fat diet
BackgroundIsoproterenol (ISO), a synthetic on selective β-adrenergic agonist, provides a simple and non-invasive method for inducing myocardial...
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Serum Free Fatty Acid Concentration Predicts ARDS after Off-Pump CABG: A Prospective Observational Study
BackgroundFree fatty acids (FFAs) are established risk factors for various cardiovascular and metabolic disorders. Elevated FFAs can trigger...
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From Energy Metabolic Change to Precision Therapy: a Holistic View of Energy Metabolism in Heart Failure
Heart failure (HF) is a complex and multifactorial disease that affects millions of people worldwide. It is characterized by metabolic disturbances...
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Sex-related differences of fatty acid-binding protein 4 and leptin levels in atrial fibrillation: an updated review
Atrial fibrillation (AF) is a prevalent cardiac arrhythmia affecting millions of individuals worldwide and posing significant challenges to...
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Myocardial glucose suppression may interfere with the detection of inflammatory cells with FDG-PET as suggested in a canine model of myocardial infarction
BackgroundAfter myocardial infarction, fibrosis and an ongoing dysregulated inflammatory response have been shown to lead to adverse cardiac...
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Practice recommendation for measuring washout rates in 123I-BMIPP fatty acid images
The purpose of this practice recommendation is to specifically identify the critical steps involved in performing and interpreting 123 I-β-methyl-iodop...
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Research progress on the relationship between bile acid metabolism and type 2 diabetes mellitus
Bile acids, which are steroid molecules originating from cholesterol and synthesized in the liver, play a pivotal role in regulating glucose...
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Branched-Chain Amino Acid Metabolism in the Failing Heart
Branched-chain amino acids (BCAAs) are essential amino acids which have critical roles in protein synthesis and energy metabolism in the body. In the...
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Admission free-fatty acid level is a predictor of the mid-term worsening renal function in patients with ST-segment elevation myocardial infarction
Whether free fatty acids (FFAs), which are generators of reactive oxygen species and substrates of cytotoxic lipid peroxidation products in proximal...
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Role of arachidonic acid in ischemic heart disease under different comorbidities: risk or protection?
In a translational study involving animal models and human subjects, Lv et al. demonstrate that arachidonic acid (AA) exhibits cardioprotective...
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Cardiac Metabolism, Reprogramming, and Diseases
AbstractCardiovascular diseases (CVD) account for the largest bulk of deaths worldwide, posing a massive burden on societies and the global...
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Mitochondria-Associated Organelle Crosstalk in Myocardial Ischemia/Reperfusion Injury
Organelle damage is a significant contributor to myocardial ischemia/reperfusion (I/R) injury. This damage often leads to disruption of endoplasmic...
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Impaired insulin-stimulated myocardial glucose metabolic rate is associated with reduced estimated myocardial energetic efficiency in subjects with different degrees of glucose tolerance
BackgroundAlterations in myocardial mechano-energetic efficiency (MEEi), which represents the capability of the left ventricles to convert the...
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Metabolism Serves as a Bridge Between Cardiomyocytes and Immune Cells in Cardiovascular Diseases
Metabolic disorders of cardiomyocytes play an important role in the progression of various cardiovascular diseases. Metabolic reprogramming can...
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Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Barth Syndrome (BTHS) is an inherited cardiomyopathy caused by defects in the mitochondrial transacylase TAFAZZIN ( Taz ), required for the synthesis...
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Inflammation and Myocardial Blood Flow in Cardiac Sarcoidosis
Purpose of the ReviewCardiac involvement in systemic sarcoidosis or isolated cardiac sarcoidosis plays a pivotal role in the clinical manifestation...