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Estimating individualized treatment effects using an individual participant data meta-analysis
BackgroundOne key aspect of personalized medicine is to identify individuals who benefit from an intervention. Some approaches have been developed to...
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Sweden’s first Take-Home Naloxone program: participant characteristics, dose endpoints and predictors for overdose reversals
BackgroundOpioid overdoses are a growing concern, particularly among people who inject drugs. Sweden, with a comparatively high proportion of...
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The Relationship Between Chromosomal Polymorphism and Male Reproductive Abnormalities
This study aims to investigate the association between chromosomal polymorphisms and abnormalities in male reproductive health. Within the period...
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Male facial rejuvenation using a combination 633, 830, and 1072 nm LED face mask
Home-based photobiomodulation is a popular treatment modality for patients seeking non-invasive aesthetic treatment. Studies demonstrate that...
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Moderators of exercise effects on self-reported cognitive functioning in cancer survivors: an individual participant data meta-analysis
PurposeThis individual participant data meta-analysis (IPD-MA) assesses exercise effects on self-reported cognitive functioning (CF) and investigates...
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Participant and GP perspectives and experiences of screening for undiagnosed type 2 diabetes in community pharmacy during the Pharmacy Diabetes Screening Trial
BackgroundThe Pharmacy Diabetes Screening Trial (PDST) evaluated three approaches to screening for undiagnosed type 2 diabetes mellitus (T2DM) in...
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Investigating for Whom Brief Substance Use Interventions Are Most Effective: An Individual Participant Data Meta-analysis
AbstractPrior research suggests that brief interventions (BIs) for alcohol and other drug use may vary in effectiveness across patient...
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Participant and workplace champion experiences of an intervention designed to reduce sitting time in desk-based workers: SMART work & life
BackgroundA cluster randomised controlled trial demonstrated the effectiveness of the SMART Work & Life (SWAL) behaviour change intervention, with...
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Participant perceptions on the acceptability and feasibility of a telemedicine-based HIV PrEP and buprenorphine/naloxone program embedded within syringe services programs: a qualitative descriptive evaluation
BackgroundPeople who inject drugs (PWID) are at risk for HIV and opioid overdose. We piloted PARTNER UP, a telemedicine-based program to provide PWID...
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Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review
IntroductionDiffuse hemispheric glioma, H3 G34-mutant (DHGs), is a newly categorized tumor in pediatric-type diffuse high-grade gliomas, World Health...
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Applying the 4Ps of social marketing to retain and engage participants in longitudinal cohort studies: generation 2 Raine study participant perspectives
BackgroundInvestigations of participant retention in longitudinal health and medical research, document strategies that work best but overlook...
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Impact of Participant Characteristics on Clinical Outcomes with iGlarLixi in Type 2 Diabetes: Post Hoc Analysis of SPARTA Japan
IntroductionThe real-world SPARTA Japan study confirmed the effectiveness and safety of the fixed-ratio combination of insulin glargine 100 U/mL plus...
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The Cure SMA Clinical Trial Experience Survey: A Study of Trial Participant Perspectives on Clinical Trial Management and Patient-Centric Management Practices
IntroductionUnderstanding clinical trial experiences can illuminate opportunities to optimize trial design and management, with potential benefits...
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The psychosocial impact of male infertility on men undergoing ICSI treatment: a qualitative study
BackgroundMale infertility is in 20–70% of cases the cause of a couple’s infertility. Severe forms of male infertility are best treated with...
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Peer Network Counseling Effects on Substance Use: an Individual Participant Data Meta-Analysis Integrating Three Randomized Controlled Trials
The current study describes an individual participant data meta-analysis (IPDMA) testing the efficacy of a peer-network counseling (PNC) intervention...
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Elevated skull fractures: an institutional experience and individual participant data meta-analysis
Elevated skull fracture (ESF) is a rare but potentially life-threatening type of skull fracture. The literature on this topic is relatively sparse....
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Male patients’ preferences for opioid use treatment programs
BackgroundA patient-centered approach to the treatment of substance use is helpful in achieving positive treatment outcomes. This study aimed to...
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Participant Engagement in Supported Employment: A Systematic Sco** Review
Purpose This study aimed to synthesise the available knowledge on how participant engagement in supported employment (SE) interventions is presented,...
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P1NP and β-CTX-1 Responses to a Prolonged, Continuous Running Bout in Young Healthy Adult Males: A Systematic Review with Individual Participant Data Meta-analysis
BackgroundCirculating biomarkers of bone formation and resorption are widely used in exercise metabolism research, but their responses to exercise...
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Male contraception: narrative review of ongoing research
BackgroundSince the release of the combined oral contraceptive pill in 1960, women have shouldered the burden of contraception and family planning....
