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Mean kinetic temperature evaluations through simulated temperature excursions and risk assessment with oral dosage usage for health programs
BackgroundTemperature excursions occur during the transport and storage of pharmaceuticals, and often result in considerable losses for public health...
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Modeling clothing as a secondary source of exposure to SVOCs across indoor microenvironments
BackgroundEvidence suggests that clothing can influence human exposure to semi-volatile organic compounds (SVOCs) through transdermal uptake and...
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Possible mechanisms and simulation modeling of FLASH radiotherapy
FLASH radiotherapy (FLASH-RT) has great potential to improve patient outcomes. It delivers radiation doses at an ultra-high dose rate...
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Kinetic modeling and parametric imaging with dynamic PET for oncological applications: general considerations, current clinical applications, and future perspectives
Dynamic PET (dPET) studies have been used until now primarily within research purposes. Although it is generally accepted that the information...
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Starting dose selection of palbociclib in Chinese patients with breast cancer based on population kinetic–pharmacodynamic model of neutropenia
Neutropenia is the most common adverse event (AE) of palbociclib, an oral CDK4/6 inhibitor for breast cancer. Neutropenia increases the risk of...
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Application of multi-gene genetic programming technique for modeling and optimization of phycoremediation of Cr(VI) from wastewater
BackgroundRemoval of Cr(VI) from wastewater is essential as it is potentially toxic and carcinogenic in nature. Bioremediation of heavy metals using...
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Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study
Abstract2-deoxy-2- [ 18 F] fluoro- d -glucose (FDG) PET is commonly used for the assessment of vessel wall inflammation. Guidelines for analysis of...
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Mechanistic Pharmacokinetic/Pharmacodynamic Modeling in Support of a Patient-Convenient, Longer Dosing Interval for Carfilzomib, a Covalent Inhibitor of the Proteasome
BackgroundCarfilzomib is an irreversible second-generation proteasome inhibitor that has a short elimination half-life but much longer...
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Kinetic study in the extraction of xanthones from Securidaca longepedunculata roots by microwave-assisted-extraction
BackgroundExtraction of active compounds from plants using microwave can be utilized as an alternative solution for conventional extraction. To well...
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18F-FDG PET and DCE kinetic modeling and their correlations in primary NSCLC: first voxel-wise correlative analysis of human simultaneous [18F]FDG PET-MRI data
ObjectivesTo decipher the correlations between PET and DCE kinetic parameters in non-small-cell lung cancer (NSCLC), by using voxel-wise analysis of...
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Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
Utility of PI3Kα inhibitors like BYL719 is limited by the acquisition of genetic and non-genetic mechanisms of resistance which cause disease...
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Kinetic modeling of 68Ga-PSMA-11 and validation of simplified methods for quantification in primary prostate cancer patients
BackgroundThe positron emission tomography (PET) ligand 68 Ga-Glu-urea-Lys(Ahx)-HBED-CC ( 68 Ga-PSMA-11) targets the prostate-specific membrane antigen...
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Assessment of Aging-Related Function Variations of P-gp Transporter in Old-Elderly Chinese CHF Patients Based on Modeling and Simulation
Background and ObjectivesP-glycoprotein (P-gp) is one of the most intensely studied transporters owing to its broad tissue distribution and substrate...
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PET KinetiX—A Software Solution for PET Parametric Imaging at the Whole Field of View Level
Kinetic modeling represents the ultimate foundations of PET quantitative imaging, a unique opportunity to better characterize the diseases or prevent...
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First results on kinetic modelling and parametric imaging of dynamic 18F-FDG datasets from a long axial FOV PET scanner in oncological patients
PurposeTo investigate the kinetics of 18 F-fluorodeoxyglucose ( 18 F-FDG) by positron emission tomography (PET) in multiple organs and test the...
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Hepatitis D Virus and HBsAg Dynamics in the era of new Antiviral Treatments
Purpose of ReviewHepatitis D virus (HDV) infection is the most severe form of chronic viral hepatitis, with no FDA-approved therapy. Progress in the...
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The Importance of Time-of-Flight Reconstruction and Point Spread Modeling in the Measurement of Myocardial Blood Flow Parameters
Purpose of ReviewAbsolute quantitation of myocardial blood flow has been recognized as one of the most important advances in nuclear cardiology. The...
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Non-invasive quantification of acute macrophagic lung inflammation with [11C](R)-PK11195 using a three-tissue compartment kinetic model in experimental acute respiratory distress syndrome
PurposeImaging of acute lung inflammation is pivotal to evaluate innovative ventilation strategies. We aimed to develop and validate a three-tissue...
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Non-invasive quantification of 18F-florbetaben with total-body EXPLORER PET
BackgroundKinetic modeling of 18 F-florbetaben provides important quantification of brain amyloid deposition in research and clinical settings but...
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Computational modeling method to estimate secondhand exposure potential from exhalations during e-vapor product use under various real-world scenarios
Potential secondhand exposure of exhaled constituents from e-vapor product (EVP) use is a public health concern. We present a computational modeling...
